The study of new prophylactic approaches in women with high risk of inflammatory pelvic organ diseases

Abstract

Objective. Efficacy of prophylactic parenteral eubiotics in both partners and of local estriol in premenopausal women with intrauterine contraceptive (IUC) was studied.

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Methods. 120 women aged 39-53 (mean age 47 ± 0,3) using copper containing IUCparticipated in this study. The women were not diagnozed to have sexually transmitted diseases (STD) and inflammatory pelvic organ diseases (IPOD) or their diseases were treated at the beginning of the study. Of them, 65 women were included into group I. They underwent a course of treatment with SolcoTrichovak. 22 males from these 65 couples were treated with SolcoUrovak. Parallely, all 65 women had a prophylactic treatment with Ovestin used as vaginal ovulae (1 ov. twice a week by 2-month courses with a 1-month interval for 9 months). The patients with contraindications to the above preparations were excluded from the study. The other 55 women formed the control group (II). Neither they no their partners used preventive measures. The both groups were equal in risk factors of STD and IPOD frequency. The women's state control for STD and IPOD was performed in 10 months. The complaints, clinical state, presence of bacterial vaginosis (BV), Chlamydiosis (Ch), Mycoplasma (M), Trichomonosis (Tr), Gonococcal infection (Gn), Candidosis (Cd) were assessed by direct immunofluorescence, cultural and PCR methods. To assess the results, we obtained we used parametric (Т-Student) criteria as statistic method.

Results. The results obtained in group I were STD and IPOD clinical signs found 13,8%, laboratory data: BV - 3%, Ch - 12,3%, M - 10,8%, Tr - 9,2%, Gn - 3%, Cd - 9,2%. Group II data were 41,8%, 25,5%, 14,5%, 14,5%, 9,1%, 3,6%, 18,2%, respectively. IUC were removed in group I in 1,5% cases while 14,5% in group II. The statistic reliability in all our cases was p<0,05.

Conclusions. Considering a decreased (by 1-8,5 times) STD and IPOD frequency in prophylactic use of eubiotics and estriol in the premenopausal women with IUC, we recommend that the above scheme should be used for both such patients and with STD, IPOD risk, especially for estrogen deficient ones.