Preterm birth: the impact of risk factors on pregnancy outcomes

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Abstract

BACKGROUND: Despite the achievements of modern obstetrics and neonatology, the problem of preterm birth remains one of the most pressing.

AIM: The aim of this study was to evaluate the influence of risk factors on the outcome of threatened preterm birth.

MATERIALS AND METHODS: This prospective cohort study included the analysis of clinical and anamnestic data of 130 patients delivered at various gestational ages. The main group comprised 68 women with preterm delivery, with the control group consisting of 62 women with timely delivery.

RESULTS: The outcome of preterm birth is adversely affected by overweight in the group of modifiable risk factors, by history of premature birth in the immediate family in the group of non-modifiable risk factors, and by a previous COVID-19, anemia and autonomic nervous system disorders in the group of potentially modifiable risk factors. The most reliable prognostic marker for the development of preterm labor was the shortening of the cervical length of less than 2.5 cm according to ultrasound.

CONCLUSIONS: The formation of risk groups based on the analysis of clinical, anamnestic, medical, and social data, as well as somatic and gynecological diseases can help avoid the development of adverse outcomes of preterm birth.

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About the authors

Regina Sh. Khalitova

Bashkir State Medical University

Email: dr_khalitova@mail.ru
ORCID iD: 0000-0002-2629-2051
SPIN-code: 5533-5782

MD

Russian Federation, 39a Gorky St., Chita, 672000

Aydar M. Ziganshin

Bashkir State Medical University

Email: zigaidar@yandex.ru
ORCID iD: 0000-0001-5474-1080
Scopus Author ID: 57196372895
ResearcherId: V-1442-2017

MD, Cand. Sci. (Med.), Assistant Professor

Russian Federation, 39a Gorky St., Chita, 672000

Irina G. Mukhametdinova

Bashkir State Medical University

Email: n-irish@mail.ru
ORCID iD: 0000-0003-2910-3495

MD

Russian Federation, 39a Gorky St., Chita, 672000

Victor A. Mudrov

Chita State Medical Academy

Author for correspondence.
Email: mudrov_viktor@mail.ru
ORCID iD: 0000-0002-5961-5400
Scopus Author ID: 57204736023

MD, Cand. Sci. (Med.), Assistant Professor

Russian Federation, 39a Gorky St., Chita, 672000

References

  1. Radzinsky VE, Orazmuradov AA, Savenkova IV. Preterm labour: an open problem in XXI century. Kuban Sci Med Bull. 2020;27(4):27−37. (In Russ.). doi: 10.25207/1608-6228-2020-27-4-27-37
  2. Rossiyskoye obshchestvo akusherov-ginekologov, Assotsiatsiya akusherskikh anesteziologov-reanimatologov, Nauchno-prakticheskiy Sovet Minzdrava RF. Prezhdevremenn•yye rody. Klinicheskiye rekomendatsii. Moscow, 2020. (In Russ.). [cited 2022 May 14]. Available from: https://base.garant.ru/75051372/
  3. Radzinsky VE, Kostin IN, Olenev AS. Preterm delivery is an unsettled World problem. Obstetrics and Gynecology. News. Opinions. Education. 2018;S3:55−64. (In Russ.). doi: 10.24411/2303-9698-2018-13909
  4. Yakovleva OV, Glukhova TN, Rogozhina IE. Evaluation of the effectiveness of measures to improve the outcomes of preterm birth (review). Evaluation of the effectiveness of measures to improve the outcomes of preterm birth. Saratov Journal of Medical Scientific Research. 2020;16(1):17−23. (In Russ.)
  5. Lamont K, Scott NW, Jones GT, Bhattacharya S. Risk of recurrent stillbirth: systematic review and meta-analysis. BMJ. 2015;350:h3080. doi: 10.1136/bmj.h3080
  6. Skripnichenko YuP, Baranov II, Tokova ZZ. Statistics of the preterm births. Russian Journal of Human Reproduction. 2014;(4)11−14. (In Russ.)
  7. Lawn JE, Kinney MV, Belizan JM, et al. Born too soon: Accelerating actions for prevention and care of 15 million newborns born too soon. Reprod Health. 2013;10(1):S6. doi: 10.1186/1742-4755-10-S1-S6
  8. Blencowe H, Cousens S, Oestergaard MZ, et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012;379(9832):2162−2172. doi: 10.1016/S0140-6736(12)60820-4
  9. World Health Organization. [Internet]. Preterm birth. [cited 2022 May 14]. Available from: https://www.who.int › detail
  10. Radzinskiy VE. Akusherskaya agressiya. Moscow: Status Praesens; 2017. (In Russ.)
  11. World Health Organization. [Internet]. The Global strategy for women’s, children’s and adolescents’ health (2016-2030): a roadmap based on evidence and country experience. [cited 2022 May 14]. Available from: https://globalstrategy.everywomaneverychild.org/pdf/EWEC_globalstrategyreport_200915_FINAL_WEB.pdf
  12. Aylamazyan EK, Kuzminykh TU. Controversial questions of preterm birth. Journal of obstetrics and women’s diseases. 2013;62(4):97−105. (In Russ.). doi: 10.17816/JOWD62497-105
  13. Zemet R, Schiff E, Manovitch Z, et al. Quantitative assessment of physical activity in pregnant women with sonographic short cervix and the risk for preterm delivery: A prospective pilot study. PLoS One. 2018;13(6):e0198949. doi: 10.1371/journal.pone.0198949
  14. Newman RB, Goldenberg RL, Iams JD, et al. Preterm prediction study: comparison of the cervical score and Bishop score for prediction of spontaneous preterm delivery. Obstet Gynecol. 2008;112(3):508−515. doi: 10.1097/AOG.0b013e3181842087
  15. Fuchs F, Monet B, Ducruet T, et al. Effect of maternal age on the risk of preterm birth: A large cohort study. PLoS One. 2018;13(1):e0191002. doi: 10.1371/journal.pone.0191002
  16. Lawlor DA, Mortensen L, Andersen AM. Mechanisms underlying the associations of maternal age with adverse perinatal outcomes: a sibling study of 264 695 Danish women and their firstborn offspring. Int J Epidemiol. 2011;40(5):1205−1214. doi: 10.1093/ije/dyr084
  17. Fraser AM, Brockert JE, Ward RH. Association of young maternal age with adverse reproductive outcomes. N Engl J Med. 1995;332(17):1113−1117. doi: 10.1056/NEJM199504273321701
  18. Mayo JA, Lu Y, Stevenson DK, et al. Parental age and preterm birth: a population-based cohort of nearly 3 million California livebirths from 2007 to 2012. J Perinatol. 2021;41(9):2156−2164. doi: 10.1038/s41372-020-00894-7
  19. Radzinsky VE, Khamoshina MB, Chakchurina IA, Orazmuradova АА. Obstetrical and perinatal complications in young primiparas. DoctorRu. 2019;162(7):6–11. (In Russ.). doi: 10.31550/1727-2378-2019-162-7-6-11
  20. Kulavsky VA, Ziganshin AM, Kulavsky EV, Ziganshina EA. The problems of premature birth in the current population of adolescent girls. Mother and Baby in Kuzbass. 2014;3(58):47−50. (In Russ.)
  21. Belokrinitskaya TE, Artymuk NV, Filippov OS, Frolova NI. Maternal and perinatal outcomes during Covid-19 pandemia in Far East and Siberian federal region of Russia. Russian Journal of Human Reproduction. 2021;27(2):130−136. (In Russ.). doi: 10.17116/repro202127021130
  22. Norwitz ER, Caughey AB. Progesterone supplementation and the prevention of preterm birth. Rev Obstet Gynecol. 2011;4(2):60−72.
  23. Wilson PW. Established risk factors and coronary artery disease: the Framingham Study. Am J Hypertens. 1994;7(7 Pt 2):7S−12S. doi: 10.1093/ajh/7.7.7s
  24. Marsoosi V, Pirjani R, Asghari Jafarabadi M, et al. Cervical gland area as an ultrasound marker for prediction of preterm delivery: A cohort study. Int J Reprod Biomed. 2017;15(11):729−734.
  25. Mudrov VA, Ziganshin AM, Yashchuk AG, et al. Possibilities for diagnosis and prediction of preterm labor at the present stage. Kazan Medical Journal. 2021;102(1):47−59. (In Russ.). doi: 10.17816/KMJ2021-47
  26. Volkov VG, Chursina OV. The modern possibilities of prediction of preterm birth. Journal of new medical technologies. Electronic. 2020;1:30−35. (In Russ.). doi: 10.24411/2075-4094-2020-16593

Supplementary files

Supplementary Files
Action
1. Fig. 1. The structure of somatic pathology of pregnant women in the studied groups according to the International Statistical Classification of Diseases and Related Health Problems (ICD-10)

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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