Use of assisted reproductive technologies in euthyroid women with antibodies to the thyroid gland. A literature review

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The presence of antibodies to thyroid peroxidase and thyroglobulin of the thyroid gland in women with infertility is more common than in the population. Some studies describe the negative effect of autoantibodies on reproductive function and the results of assisted reproductive technology (ART) programs even in the absence of impaired thyroid function. This article presents a review of literature data on the possible mechanisms of this negative influence. To date, there are no data on a significant decrease in the quality of oocytes, embryos and pregnancy rates in ART cycles in such patients. The negative effect of autoantibodies on the frequency of live births can be realized through such complications of pregnancy as miscarriage and premature birth. Currently, the possibilities for preventing these complications are poorly understood. According to recent meta-analyses, the use of levothyroxine in euthyroid patients with autoantibodies who are treated for infertility using ART methods does not result in a decrease in the frequency of miscarriage and premature birth.

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About the authors

Inga V. Gorelova

V.A. Almazov National Medical Research Center

Author for correspondence.
ORCID iD: 0000-0002-6098-1491
SPIN-code: 1207-5705

Russian Federation, Saint-Petersburg

PhD, Head of the Research Laboratory of Reproductive Technologies

Ksenia A. Prikhodko

V.A. Almazov National Medical Research Center


Russian Federation, Saint-Petersburg

resident 2 years of training 

Maxim V. Rulev

V.A. Almazov National Medical Research Center

ORCID iD: 0000-0002-7906-4634
SPIN-code: 2001-0577

Russian Federation, Saint-Petersburg

PhD, Head of the Department of Assisted Reproductive Technologies

Irina E. Zazerskaya

V.A. Almazov National Medical Research Center

ORCID iD: 0000-0003-4431-3917
SPIN-code: 5683-6741

Russian Federation, Saint-Petersburg

MD, PhD, Head of the Department of Obstetrics and Gynecology


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Copyright (c) 2020 Gorelova I.V., Prikhodko K.A., Rulev M.V., Zazerskaya I.E.

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