Saturation of pregnant women organism vitamin D and the course of perinatal period

Cover Page


The review presents the criteria of vitamin A deficiency D adopted by in different countries and approaches to the appointment of vitamin D during pregnancy. Analyzed data from the most important studies in recent years devoted to this problem.

Full Text

Restricted Access

About the authors

Yelena Yuryevna Gurkina

Almazov Federal Medical Research Centre. Institute of Perinatology and Pediatrics


Natalya Viktorovna Petrova

Almazov Federal Medical Research Centre. Institute of Perinatology and Pediatrics


Tatyana Vasilyevna Novikova

Almazov Federal Medical Research Centre. Institute of Perinatology and Pediatrics


Vladimir Vladimirovich Yuryev

Almazov Federal Medical Research Centre. Institute of Perinatology and Pediatrics


Vladimir Vladimirovich Dorofeykov

D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Department of Obstetrics and Gynecology

Irina Yevgenyevna Zazerskaya

Almazov Federal Medical Research Centre. Institute of Perinatology and Pediatrics



  1. Ковалев Д. И. Регуляция обмена кальция в организме человека. Проблемы эндокринологии. 1991; 37 (6): 161-3.
  2. Коровина Н. А. [и др.]. Остеопороз у детей: пособие для врачей. М.; 2005.
  3. Котова С. М., Карлова Н. А., Максимцева И. М., Жорина О. М. Формирование скелета у детей и подростков в норме и патологии: пособие для врачей. М.; 2002.
  4. Новикова Т. В. [и др.]. Влияние уровня витамина Д во время беременности на минеральную плотность костной ткани в послеродовой периоде. Бюллетень Федерального центра сердца, крови и эндокринологии им. В. А. Алмазова 2013; 22 (5): 26.
  5. Ширинян Л. В. [и др.]. Насыщенность организма витамином Д при угрозе прерывания беременности. Бюллетень Федерального центра сердца, крови и эндокринологии им. В. А. Алмазова 2013; 22 (5): 4.
  6. Ackakus M. [et al.]. The relationship between birth weight, 25-hydroxyvitamin D concentrations and bone mineral status in neonates. Ann. Trop. Paediatr. 2006; 26 (4): 267-75.
  7. Aruyuki F. Growth retardation induced in rat fetuses by maternal fasting and massive doses of ergocalciferol. J. Nutr.1987;117: 342-8.
  8. Bishoff-Ferrari H. A. Vitamin D - role in pregnancy and early childhood. Ann. Nutr. Metab. 2011; 59 (1): 17-21
  9. Bodnar L. M. [et al.]. High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates. J. Nutr. 2007; 137 (2): 447-52.
  10. Brooke O. G. [et al.]. Vitamin D supplements in pregnant Asian women: effects on calcium status and fetal growth. Br. Med. J. 1980; 280: 751-4.
  11. Cavalier E. [et al.]. Vitamin D deficiency in recently pregnant women. Rev. Med. Liege. 2008; 63 (2): 87-91.
  12. Cockburn F. [et al.]. Maternal vitamin D intake and mineral metabolism in mothers and their newborn infants. Br. Med. J. 1980; 281 (6232): 11-4.
  13. Datta S. [et al.]. Vitamin D deficiency in pregnant women from a non-European ethnic minority population - an interventional study. BJOG: an International Journal of Obstetrics and Gynaecology.2002;109: 905-908.
  14. Davis O. K. [et al.]. Serum parathyroid hormone (PTH) in pregnant women determined by an immunoradiometric assay for intact PTH. J. Clin. Endocrinol. Metab. 1988; 67 (4): 850-2.
  15. Dawodu A., Nath R. High prevalence of moderately severe vitamin D deficiency in preterm infants. Pediatr. Int. 2011; 53 (2): 207-10.
  16. Dawson-Hughes B. [et al.]. Estimates of optimal vitamin D status. Osteoporos Int. 2005;16 (7): 713-6.
  17. Delvin E. E. [et al.]. Vitamin D supplementation during pregnancy: effect on neonatal calcium gomeostasis. J. Pediatr. 1986; 109 (2): 328-34.
  18. De-Regil L. M. [et al.]. Vitamin D supplementation for women during pregnancy (Review). Cochrane Database of Systematic Reviews. 2012. - Art. No.: CD008873. doi: 10.1002/14651858.CD008873.pub2.
  19. Dietary reference intakes for calcium and vitamin D. Institute of medicine. 2010. Available at: (accessed 10.05.2013)
  20. Dietary reference intakes for calcium, magnesium, phosphorus, vitamin D and fluoride. Food and Nutrition Board. Washington DC: Institute of Medicine. National Academy Press; 1997.
  21. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. National guideline clearing house. 2011. Available at: (accessed 10.05.2013).
  22. Farrant H. J. W. [et al.]. Vitamin D insufficiency is common in Indian mothers but is not associated with gestational diabetes or variation in newborn size. Eur. J. Clin. Nutr. 2009; 63: 646-52.
  23. Gale C. R. [et al.]. Maternal vitamin D status during pregnancy and child outcomes. European Journal of Clinical Nutrition.2008; 62 (1): 68-77.
  24. Hathcock J. N. [et al.]. Risk assessment for vitamin D. Am. J. Clin. Nutr. 2007; 85 (1): 6-18.
  25. Heaney R. [et al.]. Human serum 25-hydrocholecalciferol response to extended oral dosing with cholecalciferol. Am. J. Clin. Nutr. 2003; 74: 204-10.
  26. Heaney R. Vitamin D: criteria for safety and efficacy.Nutr. Rev.2008; 66 (suppl.2):178-81.
  27. Holick M. F. Vitamin D deficiency a worldwide problem with health consequences. Am. J. Clin. Nutr. 2008; 87 (4): 1080-6.
  28. Holick M. F. Vitamin D status: measurement, interpretation and clinical application. Ann Epidemiol. 2009; 19: 73-8.
  29. Hollis B. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J. Nutrition.2 005; 135 (2):317-22.
  30. Hollis B. W. [et al.] Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J. Bone Mineral Research. 2001; 26 (10): 2341-57.
  31. Javaid M. K. [et al.]. Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. Lancet. 2006; 367 (9504): 36-43.
  32. Jeremiah Miller, Richard L. Gallo. Vitamin D and innate immunity. Dermatologic Therapy. 2010; 23:13-22
  33. Lee J. M. [et al.]. Vitamin D deficiency in a healthy group of mothers and newborn infants. ClinPediatr (Phila).2007; 46 (1): 42-4.
  34. Litonjua A. A. Childhood asthma may be a consequence of vitamin D deficiency. Curr. Opin. Allergy Clin. Immunology. 2009; 9 (3): 202-7.
  35. Maghbooli Z., Hossein-Nezhad A., Shafaei A. R. [et al.]. Vitamin D status in mothers and their newborns in Iran. BMC Pregnancy Childbirth. 2007; 7:1.
  36. Mahon P. [et al.]. Low maternal vitamin D status and fetal bone development: Cohort study. J. Bone Mineral Research. 2010; 25 (1): 14-9
  37. Mallet E. [et al.]. Vitamin D supplementation in pregnancy: a controlled trial of two methods. Obstet. Gynecololgy 1986; 68 (3): 300-4.
  38. Marya R. K. [et al.]. Effect of vitamin D supplementation during pregnancy on foetal growth. Indian J. Med. Res.1988; 88: 488-92.
  39. Nicolaidou P. [et al.]. Low vitamin D status in mother-newborn pairs in Greece. Calcif. Tissue Int. 2006;.78 (6): 337-42.
  40. Pierrot-Desellingny C., Souberbielle J. C. Is hypovitaminosis D one of the environmental risk factors for multiple sclerosis? Brain. 2010; 133: 1869-88.
  41. Sahu M. [et al.]. Vitamin D replacement in pregnant women in rural north India. Eur. J. Clin. Nutr. 2009; 63 (9):1 157-9.
  42. Seely E. W. [et al.]. A prospective study of calciotropic hormones in pregnancy and post partum: reciprocal changes in serum intact parathyroid hormone and 1,25-dihydroxyvitamin D. Am. J. Obstet. Gynecol.1 997; 176 (1, pt.1): 214-7.
  43. Specker B. Vitamin D requirements during pregnancy. Am. J. Clin. Nutr. 2004; 80 (6, suppl.): 1740S-7S.
  44. The National Academies PressWashington, DC IOM guidelines for VD supplementation with a special section devoted to pregnancy. Dietary Reference Intakes for Calcium and Vitamin D. 2011
  45. Thomson K. [et al.]. Postnatal evaluation of vitamin D and bone health in women who were vitamin D-deficient in pregnancy, and in their infants. Med J. Aust. 2004; 181 (9): 486-8.
  46. Van der Meer I. M. [et al.]. High prevalence of vitamin D deficiency in pregnant non-Western women in The Hague, Netherlands. Am. J. Clin. Nutr. 2006; 84 (2): 350-3.
  47. Vieth R., Chan P. C. R., MacFarlane G. D. Efficacy and safety of vit.D3 intake exceeding the lowest observed adverse effect level. Am. J. Clin. Nutr. 2001; 73: 288-94.
  48. Vitamin D supplementation in pregnancy: a necessity. Committee for nutrition [article in French]. Arch. Pediatr.1995; 2: 373-6.
  49. Vitamin D supplementation: recommendations for Canadian mothers and infants. Pediatric Child Health. 2007; 12 (7): 583-9.
  50. Wagner C. L., Greer F. R. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008; 122: 1142-52.
  51. Wagner С. L. Vitamin D and its role during pregnancy in attaining optimal health of mother and fetus. Nutrients. 2012; 4: 208-30.
  52. Walker V. P., Modlin R. L. Vitamin D connection to pediatric infections and immune function. Pediatric Research. 2009; 65 (5, pt.2): 106-13.
  53. Yu C. K. [et al.]. Vitamin D deficiency and supplement during pregnancy. Clin. Endocrinol. 2009; 70 (5): 685-90.



Abstract - 445

PDF (Russian) - 338



Copyright (c) 2014 Gurkina Y.Y., Petrova N.V., Novikova T.V., Yuryev V.V., Dorofeykov V.V., Zazerskaya I.Y.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies