Role of Kisspeptine in Regulation of Reproductive Function

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Abstract

Research objective: to identify a role of kisspeptine in the regulation of reproduction function.

Materials: literature data by foreign authors for the period from 1985 till 2016.

Methods: systematic analysis and compilation of information in the literature.

Results. The article provides a review of literature data on research of kisspeptine gene and its receptor; it includes description of their role in regulation of reproduction function and mutation in the genes responsible for realization of kisspeptine and neurokinin signaling pathways. Features of kisspeptine secretion in patients with hypogonadotropic hypogonadism, premature sexual development, hyperprolactinemic deficiency of ovaries, polycystic ovarian syndrome, genital endometriosis and opportunity of kisspeptine use in clinical practice as an ovulation trigger are described.

Conclusion. It is necessary to carry out further studies for clarification of kisspeptine role in patients with various diseases and the opportunity of its use as a therapeutic target.

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About the authors

Maria I Yarmolinskaya

FSBSI “The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott”

Author for correspondence.
Email: m.yarmolinskaya@gmail.com
professor of Russian Academy of Sciences, leading research assistant of department of endocrinology of reproduction, Doctor of medical sciences, head of center “Diagnostics and treatment of endometriosis” Russian Federation

Nigar F Ganbarli

FSBSI “The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott”

Email: n-ganbarli@mail.ru
3rd year post-graduate student of Surgical Gynecology Department Russian Federation

Eduard K Ailamazian

FSBSI “The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott”

Email: iagmail@ott.ru
Professor, Academician of RAS, Director Russian Federation

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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