Inflammaging and prognostic markers of endometriosis

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Abstract

Inflammaging, an age-associated inflammation, is a cellular stress response caused by DNA damage, activation of oncogenes or inactivation of tumor suppressors, oxidative stress, chemotherapy, mitochondrial dysfunction, or epigenetic changes. Damage to macromolecules leads to the cessation of proliferation due to the activation of pathways such as p53/p21CIP1 and p16INK4a/RB. These form the senescence-associated secretory phenotype (SASP), the molecular/cellular manifestations of which in endometrial cells have features similar to those observed in endometriosis. Presently, there are no uniform diagnostic criteria or established molecular markers that can predict the development and course of endometriosis. In this regard, it is relevant to develop new minimally invasive examination methods, statistically based criteria and molecular markers for early diagnosis and prognosis of endometriosis.

This review article is devoted to identifying molecular markers that characterize the pathogenesis of endometriosis during inflaming. The aim of the study was to consider modern ideas about the mechanisms of inflaming and its role in the development of endometriosis to determine possible molecular markers for predicting the course of the pathology. We used the PubMed, Scopus and Google Scholar databases to analyze and systematize the literature over the past ten years. Our review reflects the main molecular mechanisms and prognostic criteria that characterize the development of endometriosis during inflaming.

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About the authors

Anastasia A. Shteiman

Saint Petersburg Institute of Bioregulation and Gerontology

Email: molpathol@bk.ru
ORCID iD: 0000-0002-4209-7133
SPIN-code: 4243-3599

MD, Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

Yulia S. Krylova

Academician I.P. Pavlov First Saint Petersburg State Medical University; Saint Petersburg Institute of Phthisiopulmonology

Email: emerald2008@mail.ru
ORCID iD: 0000-0002-8698-7904
SPIN-code: 9729-7872

MD, Cand. Sci. (Med.)

Russian Federation, Saint Petersburg; Saint Petersburg

Mikhail A. Dokhov

Saint Petersburg Institute of Phthisiopulmonology; Saint Petersburg State Pediatric Medical University

Author for correspondence.
Email: mad20@mail.ru
ORCID iD: 0000-0002-7834-5522
SPIN-code: 5849-5932

MD, Cand. Sci. (Med.)

Russian Federation, 2-4 Ligovsky Ave., Saint Petersburg, 191036; Saint Petersburg

Tatyana S. Zubareva

Saint Petersburg Institute of Bioregulation and Gerontology; Saint Petersburg Institute of Phthisiopulmonology

Email: molpathol@bk.ru
ORCID iD: 0000-0001-9518-2916
SPIN-code: 2725-6105

Cand. Sci. (Biol.)

Russian Federation, Saint Petersburg; 2-4 Ligovsky Ave., Saint Petersburg, 191036

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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