Oxytocin: physiological and pathophysiological determinants. A review

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Abstract

Oxytocin is a pleiotropic peptide hormone that plays a leading role in the implementation of the tonomotor activity of the myometrium during labor. Over the past decade, significant progress has been made in understanding the complex neurobiology of the oxytocin system, including oxytocinergic pathways, local release patterns and distribution of oxytocin receptors in the brain, and intra-neuronal oxytocin receptor signaling. This article presents the view of modern researchers on the biological functions of the hormone, including its participation in onco- and immunogenesis, as well as in the implementation of adaptation, reproduction and social behavior in humans.

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About the authors

Olga V. Prokhorova

Ural State Medical University

Author for correspondence.
Email: prokhorova-ov@yandex.ru
ORCID iD: 0000-0002-9051-4528

MD, Cand. Sci. (Med.), Assistant Professor

Russian Federation, Ekaterinburg

Anna A. Olina

The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; North-Western State Medical University named after I.I. Mechnikov; Perm State Medical University named after Academician E.A. Wagner

Email: olina29@mail.ru
ORCID iD: 0000-0001-9101-7569
SPIN-code: 4255-4325
Scopus Author ID: 56021173500
ResearcherId: T-8423-2017

MD, Dr. Sci. (Med.), Professor

Russian Federation, Saint Petersburg; Saint Petersburg; Perm

Gulrukhsor Kh. Tolibova

The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; North-Western State Medical University named after I.I. Mechnikov

Email: gulyatolibova@yandex.ru
ORCID iD: 0000-0002-6216-6220
SPIN-code: 7544-4825
Scopus Author ID: 23111355700
ResearcherId: Y-6671-2018

MD, Dr. Sci. (Med.)

Russian Federation, Saint Petersburg

Tatyana G. Tral

The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; Saint Petersburg State Pediatric Medical University

Email: ttg.tral@yandex.ru
ORCID iD: 0000-0001-8948-4811
SPIN-code: 1244-9631
Scopus Author ID: 37666260400

MD, Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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