The role of vitamin D in the pathogenesis of genital endometriosis

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Abstract


The influence of vitamin D on the women’s health is undeniable. Here we review the modern classification of vitamin D forms and receptors, the current understanding of genomic and non-genomic regulation pathways of vitamin D synthesis. It was found that a vitamin D deficiency related to the development of many diseases, negative impact on reproductive function and pregnancy outcomes. Nowadays, vitamin D is concerned as a prohormone that has multiple effects. Special attention is given to the role of vitamin D in the pathogenesis of genital endometriosis. It is known that vitamin D has anti-inflammatory, antiproliferative and immunomodulating effects, which allow it to be considered as a forward-looking target therapy in endometriosis.


Alexandra S. Denisova

Author for correspondence.
al.ser.denisova@gmail.com
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Russian Federation, Saint Petersburg

obstetrician-gynecologist of outpatient department

Mariya I. Yarmolinskaya

m.yarmolinskaya@gmail.com
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; North-Western State Medical University named after I.I. Mechnikov
Russian Federation, Saint Petersburg; Saint Petersburg

professor of RAS, head of Department of Endocrinology of Reproduction, Doctor of medical sciences, head of Center Diagnostics and Treatment of Endometriosis

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