Adenomyosis and fertility: a modern view of the problem. A literature review

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Abstract

This literature review is based on resources from the following databases: CyberLeninka, PubMed, MedArt, and the Central Scientific Medical Library (I.M. Sechenov First Moscow State Medical University, Moscow, Russia). Adenomyosis is a common non-infectious uterine pathology associated with the risk of infertility and obstetric problems. The local inflammation that develops in adenomyosis reduces the probability of blastocyst implantation and creates an unfavorable environment for the development of the embryo. Adenomyosis reduces the effectiveness of assisted reproductive technology. During the pregnancy in adenomyosis, the risk of incomplete and prolonged pregnancy increases at almost all stages. Besides, the risk of massive hemorrhage increases during pregnancy, childbirth and the early postpartum period. The presented review helps to assess the pathogenetic mechanisms underlying the negative effect of adenomyosis on women’s fertility based on data obtained over the past ten years.

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About the authors

Vitaly F. Bezhenar

Academician I.P. Pavlov First Saint Petersburg State Medical University

Author for correspondence.
Email: bez-vitaliy@yandex.ru
ORCID iD: 0000-0002-7807-4929
SPIN-code: 8626-7555
ResearcherId: R-7055-2017

MD, Dr. Sci. (Med.), Professor

Russian Federation, 6-8, L’va Tolstogo St., Saint Petersburg, 197022

Viktor A. Linde

Academician I.P. Pavlov First Saint Petersburg State Medical University

Email: vik-linde@yandex.ru
ORCID iD: 0000-0002-6032-1936
Scopus Author ID: 56825712100

MD, Dr. Sci. (Med.), Professor

Russian Federation, 6-8, L’va Tolstogo St., Saint Petersburg, 197022

Byuzand V. Arakelyan

Academician I.P. Pavlov First Saint Petersburg State Medical University

Email: byuzand@mail.ru
ORCID iD: 0000-0002-2868-7997

MD, Dr. Sci. (Med.), Assistant Professor

Russian Federation, 6-8, L’va Tolstogo St., Saint Petersburg, 197022

Alla S. Kalugina

Academician I.P. Pavlov First Saint Petersburg State Medical University

Email: alla19021962@gmail.com
ORCID iD: 0000-0002-4796-7812
ResearcherId: B-6355-2016

MD, Dr. Sci. (Med.), Professor

Russian Federation, 6-8, L’va Tolstogo St., Saint Petersburg, 197022

Yuri V. Vasilyev

Saint Petersburg State Pediatric Medical University

Email: yvw@mail.ru
ORCID iD: 0000-0001-5102-1774

MD, Cand. Sci. (Med.), Assistant Professor

Russian Federation, Saint Petersburg

Darya A. Sobakina

City Alexandrovskaya Hospital

Email: sobakina-d@mail.ru
ORCID iD: 0000-0002-4610-4126

MD

Russian Federation, Saint Petersburg

Elmina E. Sadykhova

Academician I.P. Pavlov First Saint Petersburg State Medical University

Email: dr.elminasadykhova@yandex.ru
ORCID iD: 0000-0003-1157-7801

MD

Russian Federation, 6-8, L’va Tolstogo St., Saint Petersburg, 197022

Viktoria A. Tarasenkova

City Alexandrovskaya Hospital

Email: victorious.vik@yandex.ru
ORCID iD: 0000-0003-2405-2780

MD

Russian Federation, Saint Petersburg

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия Эл № 77 - 6389 от 15.07.2002 г.


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