Email this article Efficacy of using recombinant granulocyte colony-stimulating factor in IVF/ICSI protocols in patients with predicted suboptimal response to controlled ovarian stimulation
- Authors: Nguyen C.T.1, Kogan I.Y.1,2, Niauri D.A.1,2, Makhmadaliyeva M.R.2, Dzhemlikhanova L.K.1,2, Krikheli I.O.2, Tapilskaya N.I.2,3, Obyedkova K.V.2, Abdulkadyrova Z.K.1, Tran T.T.4, Mekina I.D.2, Lesik E.A.2, Komarova E.M.2, Ishchuk M.A.2, Gzgzyan A.M.1,2
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Affiliations:
- Saint Petersburg State University
- The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- Saint Petersburg State Pediatric Medical University
- Hanoi National University of Education
- Issue: Vol 71, No 1 (2022)
- Pages: 59-70
- Section: Original Research
- URL: https://journals.eco-vector.com/jowd/article/view/81947
- DOI: https://doi.org/10.17816/JOWD81947
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Abstract
BACKGROUND: According to most studies, the efficacy of IVF/ICSI protocols in patients with suboptimal response was significantly lower than in women with normal response. However, methodological approaches optimizing the efficacy of IVF/ICSI protocols in patients with suboptimal response have not been developed.
AIM: The aim of this study was to evaluate the efficacy of using recombinant granulocyte colony-stimulating factor in IVF/ICSI protocols in women with predicted suboptimal response to controlled ovarian stimulation.
MATERIALS AND METHODS: This prospective study included 102 patients with predicted suboptimal response: treatment group (n = 34) and comparison group (n = 68). Controlled ovarian stimulation was performed according to the standard protocol with gonadotropin-releasing hormone antagonists. Women in treatment group daily received 60 mcg of recombinant granulocyte colony-stimulating factor subcutaneously from the onset of stimulation until the day of human chorionic gonadotropin blood test. The intergroup comparative analysis included clinical-anamnestic data, indicators of hormonal status, ovarian reserve, main characteristics of protocols stimulation, embryological data and the efficacy of IVF/ICSI programs.
RESULTS: In the treatment group, the number of retrieval oocytes was higher (8.1 ± 5.3 vs. 4.7 ± 2.6, respectively; p < 0.001), and the effective dose of follicle-stimulating hormone preparations was lower than in the comparison group (403.6 ± 351.1 IU vs. 694.3 ± 950.4 IU, respectively; p = 0.013). Besides, the number of mature oocytes (6.8 ± 5.2 vs. 3.7 ± 1.9, respectively; p < 0.01), 2PN zygotes (5.1 ± 3.9 vs. 2.8 ± 1.7, respectively; p < 0.01), and good quality embryos (3.4 ± 3.3 vs. 1.8 ± 1.5, respectively; p < 0.01) were also higher in the treatment group. Сlinical pregnancy rate in women receiving recombinant granulocyte colony-stimulating factor was significantly higher (41.2% vs. 22.1%, respectively; OR 2.47; 95% CI 1.01–6.03; p < 0.05).
CONCLUSIONS: Using recombinant granulocyte colony-stimulating factor improves the efficacy of IVF/ICSI protocols in women with predicted suboptimal response.
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About the authors
Cong T. Nguyen
Saint Petersburg State University
Author for correspondence.
Email: dr.tuan99999@gmail.com
ORCID iD: 0000-0002-4665-9025
MD
Russian Federation, 7–9, Universitetskaya nab., Saint Petersburg, 199034Igor Yu. Kogan
Saint Petersburg State University; The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: ikogan@mail.ru
ORCID iD: 0000-0002-7351-6900
SPIN-code: 6572-6450
MD, Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences
Russian Federation, 7–9, Universitetskaya nab., Saint Petersburg, 199034; Saint PetersburgDariko A. Niauri
Saint Petersburg State University; The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: d.niauri@mail.ru
ORCID iD: 0000-0003-1556-248X
SPIN-code: 4384-9785
MD, Dr. Sci. (Med.), Professor
Russian Federation, 7–9, Universitetskaya nab., Saint Petersburg, 199034; Saint PetersburgManizha R. Makhmadaliyeva
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: 2563737@mail.ru
ORCID iD: 0000-0002-9578-8931
MD
Russian Federation, Saint PetersburgLyailya Kh. Dzhemlikhanova
Saint Petersburg State University; The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: dzhemlikhanova_l@mail.ru
ORCID iD: 0000-0001-6842-4430
SPIN-code: 1691-6559
MD, Cand. Sci. (Med.)
Russian Federation, 7–9, Universitetskaya nab., Saint Petersburg, 199034; Saint PetersburgInna O. Krikheli
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: ikrikhely@gmail.com
ORCID iD: 0000-0002-5439-1727
SPIN-code: 7356-6189
MD, Cand. Sci. (Med.)
Russian Federation, Saint PetersburgNatalya I. Tapilskaya
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; Saint Petersburg State Pediatric Medical University
Email: tapnatalia@yandex.ru
ORCID iD: 0000-0001-5309-0087
Scopus Author ID: 23013489000
MD, Dr. Sci. (Med.), Professor
Russian Federation, Saint Petersburg; Saint PetersburgKsenia V. Obyedkova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: obedkova_ks@mail.ru
ORCID iD: 0000-0002-2056-7907
Scopus Author ID: 57201161145
MD, Cand. Sci. (Med.)
Russian Federation, Saint PetersburgZarina K. Abdulkadyrova
Saint Petersburg State University
Email: spb.zarika.los@mail.ru
ORCID iD: 0000-0002-2154-298X
MD, Cand. Sci. (Med.)
Russian Federation, 7–9, Universitetskaya nab., Saint Petersburg, 199034Toan Thai Tran
Hanoi National University of Education
Email: tstranthaitoan@gmail.com
ORCID iD: 0000-0002-7263-6150
Cand. Sci. (Biol.)
Viet Nam, HanoiIrina D. Mekina
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: iagmail@ott.ru
ORCID iD: 0000-0002-0813-5845
SPIN-code: 4682-8590
Cand. Sci. (Biol.)
Russian Federation, Saint PetersburgElena A. Lesik
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: lesike@yandex.ru
ORCID iD: 0000-0003-1611-6318
Cand. Sci. (Biol.)
Russian Federation, Saint PetersburgEvgenia M. Komarova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: evgmkomarova@gmail.com
ORCID iD: 0000-0002-9988-9879
SPIN-code: 1056-7821
Cand. Sci. (Biol.)
Russian Federation, Saint PetersburgMaria A. Ishchuk
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: mashamazilina@gmail.com
ORCID iD: 0000-0002-4443-4287
Scopus Author ID: 57194177084
Russian Federation, Saint Petersburg
Alexandr M. Gzgzyan
Saint Petersburg State University; The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: agzgzyan@gmail.com
ORCID iD: 0000-0003-3917-9493
SPIN-code: 6412-4801
MD, Dr. Sci. (Med.)
Russian Federation, 7–9, Universitetskaya nab., Saint Petersburg, 199034; Saint PetersburgReferences
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