The role of melatonin in development of gestational diabetes mellitus

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Abstract


This review summarizes many of the published reports about the production of melatonin and it’s role in regulation of carbohydrate metabolism, interrelationships between melatonin, insulin, glucagon and diurnal signaling the blood-glucose-regulating of the islet. The results of experimental and clinical investigations support that low melatonin levels and absence it’s circadian rhythm play the role in the development of gestational diabetes mellitus in womens with pathology of neuroimmunoendocrinology system and suggest the possibility of prognosis and prophylactic this complication of pregnancy.


Edvard K. Aulamazyan

Author for correspondence.
iagmail@ott.ru
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Russian Federation, Saint Petersburg

Chief, Academician of Russian Academy of Sciences, Professor

Inna I. Evsyukova

eevs@yandex.ru
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Russian Federation, Saint Petersburg

MD, PhD, Dr Med Sci, Professor, leading research assistant of Department of Physiology and Pathology of Newborns

Maria I. Yarmolinskaya

m.yarmolinskaya@gmail.com
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Russian Federation, Saint Petersburg

Professor of Russian Academy of Sciences, Head of Department of Endocrinology of Reproduction, Doctor of Medical Sciences

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