Email this article Evaluation of free radical processes in metabolism in combined hyperplasias of the female reproductive system
- Authors: Chepur S.V.1, Popov Е.N.1, Niauri D.А.1
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Affiliations:
- D.O. Ott Obstetrics and Gynecology Research Institute, Russian Academy of Medical Sciences, Saint Petersburg State University
- Issue: Vol 54, No 5S (2005)
- Pages: 38-38
- Section: Reviews
- URL: https://journals.eco-vector.com/jowd/article/view/87267
- DOI: https://doi.org/10.17816/JOWD87267
- ID: 87267
Cite item
Abstract
Relevance. It is known that free radical metabolic reactions are involved in the development and progression of the development of various destructive and hyperplastic processes in tissues. In this regard, the aim of this study was to compare the severity of disorders of the pro- and antioxidant system in single and multiple benign tumors of the female reproductive system.
Full Text
Introduction. Free radical metabolic reactions are known to play a major role in the progression of a variety of destructive and hyperplastic processes in living tissues. The goal of the current study was the comparison of function of pro- and antioxidant systems in solitary and multiple benign tumors of female reproductive system organs.
Material and Methods. 56 patients, age 40-45, mean age 41 ± 0.8 years were examined. In 18 patients solitary myomatous intramural nodes, mean diameter 12 ± 4 cm, were found. In other 38 women intramural hysteromyoma was combined with: in 18 patients (47,4%) with adenomatous and/or adenoid cystic endometrial hyperplasia, in 12 patients (31,6%) with adenomyosis and endometrial hyperplasias, and in 8 (21%) with genital endometryosis (endometryoid ovarian cysts). Infrared spectroscopy studies with FMEL- 1 apparatus (Russia) were carried out to evaluate the changes in metabolism. A batch of lyophilized tissue was grinded in agate pounder with 250 mg of KBr monocrystal and molded into tablets. Infrared absorption spectra were evaluated compared to the standard KBr tablet in the comparison channel in spectral range of 400-4000 cm-1.
Results. The results of infrared spectroscopy of the lyophilized tissues of myomas, intact endometrium and plasma in all patients with combined hyperplastic lesions of the reproductive system organs were similar. A stable peak with a wavenumber over 3500 cm-1 was found. The patients with solitary myomas lacked the described peak.
Conclusions. Therefore, cumulation of molecules with oxidized OH-fragments and changes in the balance of OH- and NH-containing compounds is evident in the tissues of reproductive system of patients with combined hyperplasias. These results indicate that the tissues of reproductive system of females with combined hyperplasias suffer from cascade reactions of oxidative stress, which is characterized by uncontrolled production of free radicals and/or insufficiency of antiradical protection mechanisms. The uniformity of the results of spectroscopy studies of tissues and plasma allows the non-invasive evaluation of free radical processes in patients with combined hyperplasias of the reproductive system. The results of such studies could provide the rationale for pathogenetically-oriented approach to treatment.
About the authors
S. V. Chepur
D.O. Ott Obstetrics and Gynecology Research Institute, Russian Academy of Medical Sciences, Saint Petersburg State University
Author for correspondence.
Email: info@eco-vector.com
Department of Obstetrics and Gynecology, College of Medicine
Russian Federation, Saint Petersburg; Saint Petersburg
Е. N. Popov
D.O. Ott Obstetrics and Gynecology Research Institute, Russian Academy of Medical Sciences, Saint Petersburg State University
Email: info@eco-vector.com
Department of Obstetrics and Gynecology, College of Medicine
Russian Federation, Saint Petersburg; Saint PetersburgD. А. Niauri
D.O. Ott Obstetrics and Gynecology Research Institute, Russian Academy of Medical Sciences, Saint Petersburg State University
Email: info@eco-vector.com
Department of Obstetrics and Gynecology, College of Medicine
Russian Federation, Saint Petersburg; Saint PetersburgReferences
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