Efficiency of different biopsy methods of adenomyosis diagnosis, comparative analisis

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Abstract

Introduction.Usage of low invasive methods in adenomyosis diagnosis helps to diagnose adenomyosis definitely by histological examination of myometrium samples.

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Introduction.Usage of low invasive methods in adenomyosis diagnosis helps to diagnose adenomyosis definitely by histological examination of myometrium samples.

Material and methods. Hysterectomy specimen (n=32), in 24 (75%) cases the adenomyosis was confirmed by pathologic examination. Imitation of transcervical and transabdominal puncture biopsy, pinch and resection biopsy in vitro were performed.

Results:

  • pinch biopsy is characterized by low volume of myometrium sample ~lmm3, unavailability to obtain deep located areas of myometrium,
  • resectobiopsy is characterized by unavailability to obtain deep located areas of myometrium, high side thermal necrosis, making 70% of preparation impossible for histological analysis.
  • Sensitivity of transcervical puncture biopsy for 5-nodular is 48%, 6-8 nodular - 83%, this method provides possibility to obtain deep located areas of myometrium;
  • transabdominal puncture biopsy gets tissue samples from external zones of myometrium, making impossible determine the depth of endometrial invasion. Sensitivity of transabdominal biopsy is 58% for 8-nodular biopsy.
  • 6-nodular transcervical biopsy - is the optimal method to obtain histological samples confirming adenomyosis.
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About the authors

S. A. Povzun

The D.O.Ott Research Institution of Obstetrics and Gynecology RAMS'

Author for correspondence.
Email: info@eco-vector.com

Department of Pathological Anatomy

Russian Federation, Saint Petersburg

V. F. Bezhenar

The D.O.Ott Research Institution of Obstetrics and Gynecology RAMS'

Email: info@eco-vector.com

Department of Pathological Anatomy

Russian Federation, Saint Petersburg

Y. V. Tsvelev

Medical-Military Academy

Email: info@eco-vector.com

Department of Obstetrics and Gynecology

Russian Federation, Saint Petersburg

D. B. Fridman

The D.O.Ott Research Institution of Obstetrics and Gynecology RAMS'; Medical-Military Academy

Email: info@eco-vector.com

Department of Pathological Anatomy, Department of Obstetrics and Gynecology

Russian Federation, Saint Petersburg; Saint Petersburg

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