Homeostasis in patients with ovarian benign tumors and reproductive function disorders
- Authors: Kulakov V.I.1, Sukhikh G.T.1, Gataulina R.G.1, Sarkisov S.E.1, Vanko L.V.1, Menginskaya I.V.1, Movsisyan E.T.1, Bargesyan G.O.1
-
Affiliations:
- Scientific Centre of Obstetrics, Gynecology and Perinatology, RAMS
- Issue: Vol 54, No 5S (2005)
- Pages: 53-54
- Section: Reviews
- URL: https://journals.eco-vector.com/jowd/article/view/87408
- DOI: https://doi.org/10.17816/JOWD87408
- ID: 87408
Cite item
Abstract
Objective: the elicitation of immune status changes in patients with benign ovarian tumors and reproductive function disorders.
Full Text
Objective: the elicitation of immune status changes in patients with benign ovarian tumors and reproductive function disorders.
Materials and methods. 53 women with benign ovarian tumors and reproductive function disorders were examined with dynamic pelvic ultrasound, hysterosalpingography, haemostasis investigations, biochemical, ednocrine and immunological tests. The latter included the examination of systemic and local immunity, detection of anti-phospholipid, anti-progesterone and antiovarial antibodies. Also laparoscopic surgeries (laparoscopy and hysteroscopy) were carried out as usually.
Results. The primary infertility was marked in 58,9%, the secondary one - in 41,1% of observations. Most patients had history of inflammatory and infectiouse diseases. Different menstrual function disorders were diagnosed at 50,2% of women, uterine lesions included fibroid (29,1%), endometritis (47,5%); uterine
cervix diseases -45,2% (chronical cervicitis, leukoplakia, deformation and scarred changes after traumatic delivery). Every 2nd woman was polivalent allergic, that testified indirectly about autoimmune disorders. The ovarian tumors were revealed in 37,4% of patients, tumor-like mass - in 62,6%. Changes of coagulation system (hypercoagulation) were more freqently observed in women with epithelial, herminogenic tumors and endometriomas. The latter was combined with thyroid dysfunction very often. Dishormonal diseases of mammae and galactorrhea were revealed in the most of women. The evaluation of immune system changes in patients with infertility and benign ovarian tumors confirmed the presence of systemic disorders, which were more manifest in combined pathological processes. These patients were characterized by decreasing of T-helper (CD4+) relative content and increasing of B-lymphocytes (CD 19+), NK-cells (CD 16+), T-cells with γδ-receptors and increased concentration of IgM and IgA. Also the essential changes of interferonogenesis were found. Higher concentrations of antiphospholipid, antiprogesterone and antiovarial antibodies were detected in patients with different forms of endometriosis.
Conclusion. This group of patients has significant homeostatic disorders manifested of polymorphic lesions of different systems that evidences for autoimmune factor role in infertility genesis in ovarian tumors and tumor-like mass.
About the authors
V. I. Kulakov
Scientific Centre of Obstetrics, Gynecology and Perinatology, RAMS
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Moscow
G. T. Sukhikh
Scientific Centre of Obstetrics, Gynecology and Perinatology, RAMS
Email: info@eco-vector.com
Russian Federation, Moscow
R. G. Gataulina
Scientific Centre of Obstetrics, Gynecology and Perinatology, RAMS
Email: info@eco-vector.com
Russian Federation, Moscow
S. E. Sarkisov
Scientific Centre of Obstetrics, Gynecology and Perinatology, RAMS
Email: info@eco-vector.com
Russian Federation, Moscow
L. V. Vanko
Scientific Centre of Obstetrics, Gynecology and Perinatology, RAMS
Email: info@eco-vector.com
Russian Federation, Moscow
I. V. Menginskaya
Scientific Centre of Obstetrics, Gynecology and Perinatology, RAMS
Email: info@eco-vector.com
Russian Federation, Moscow
E. T. Movsisyan
Scientific Centre of Obstetrics, Gynecology and Perinatology, RAMS
Email: info@eco-vector.com
Russian Federation, Moscow
G. O. Bargesyan
Scientific Centre of Obstetrics, Gynecology and Perinatology, RAMS
Email: info@eco-vector.com
Russian Federation, Moscow