Email this article The role of ctd in genital prolapse genesis
- Authors: Buyanova S.N.1, Savelyev S.V.1, Petrova V.D.1, Muravyeva Т.G.1, Putilovskiy М.А.1
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Affiliations:
- Moscow regional scientific research institute of obstetrics and gynecology
- Issue: Vol 54, No 5S (2005)
- Pages: 62-63
- Section: Reviews
- URL: https://journals.eco-vector.com/jowd/article/view/87446
- DOI: https://doi.org/10.17816/JOWD87446
- ID: 87446
Cite item
Abstract
Background: now the role of connective tissue displasia (CTD) in genesis of genital prolapse is known. Genital prolaps as nondifferentiated kind of CTD is a manifestation of generalized CTD on the level of reproductive system which developes in young unipara women after noncomplicated delivery without hormonal disorders and factors provided intraabdominal pressure increasing.
Full Text
Background: now the role of connective tissue displasia (CTD) in genesis of genital prolapse is known. Genital prolaps as nondifferentiated kind of CTD is a manifestation of generalized CTD on the level of reproductive system which developes in young unipara women after noncomplicated delivery without hormonal disorders and factors provided intraabdominal pressure increasing.
Materials and methods. First of all connective tissue defects are connected with altered synthesis of collagen. The immunohistochemical investigation of intraoperative samples: vessels and surrounding tissues, pelvic fascia and ligaments was performed in patient with CTD to evaluate the morphological structure and quality of collagen content.
Results. 61,9% of 21 patients with CTD did not have macroscopic changes of examined tissues.The 1st and IIId types of collagen were expressed in all patients with CTD but both collagens had atypical structure and did not form fiber funiculus. Instead of Ist and IIId types of collagen a lot of IV type of collagen was expressed that realized in decreasing of elasticity of ligamental apparatus.
Clinical and constitutional signs of CTD were revealed in 104 (24,1%) from 432 examined paients with different forms of urine incontinence which combined with anatomical disposition of pelvic organs at 81,5% of cases. These patient more often showed CTD markers.
Conclusion. Instead of known criteria of CTD expression we offer to use the list of the most significant signs. The combination of three or more of them testifies about nondifferentiated CTD.
About the authors
S. N. Buyanova
Moscow regional scientific research institute of obstetrics and gynecology
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Moscow
S. V. Savelyev
Moscow regional scientific research institute of obstetrics and gynecology
Email: info@eco-vector.com
Russian Federation, Moscow
V. D. Petrova
Moscow regional scientific research institute of obstetrics and gynecology
Email: info@eco-vector.com
Russian Federation, Moscow
Т. G. Muravyeva
Moscow regional scientific research institute of obstetrics and gynecology
Email: info@eco-vector.com
Russian Federation, Moscow
М. А. Putilovskiy
Moscow regional scientific research institute of obstetrics and gynecology
Email: info@eco-vector.com
Russian Federation, Moscow
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