The importance of the latent connective tissue dysplasia in the pathogenesis of the cervix elongation

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Introduction. The genital prolapse (PG) is actual clinical and surgical problem. Recidive’s frequency is still 33% after surgical treatment of the complicated cases. The cervix elongation (CE), which is one from the PG’s forms, isn’t diagnosed from early stages of the development. In the scientific literature it has written about latent connective tissue dysplasia’s (CTD) importance in the PG’s development.

Material and methods. We exposed the clinic, morphological, immunohistochemical manifestations with studying of the CTD’s role in the CE’s development. We inspected 158 patients with 1-3 degree’s CE in the two age groups (before and after 45 years). The operating treatment: Manchesterskaya operation - 122 observations, the vaginal uteri’s extirpation - 26, the vaginal extirpation of the cervix’s stump - 10.

Results. The manifestations of the important and secondary signs of the CTD were exposed from all patients by the clinical questionnaire. The important signs of the CTD (genital prolapse of the family’s first generation, varicose veins, hemorrhoid, allergopathy, more rapid delivers) were exposed in 50% patients of the 1 group and in 100% - of the 2 group. In 1-2 CE’s degree had been 1 CTD’s degree and in 3-2 CTD’s degree. The disturbance of the architectonic, connective, muscle tissues’s, vessels’s topography, collagenization of the argirophilic fibres, muscle tissue’s atrophic were exposed by the histological investigation. The changenment of the accumulation and distribution of the 1, 2, 3 types’s collagens were ascertained by the immunohistochemical investigation. These processes confirm CTD and lead to the cervix’s inferiority.

Conclusions. The results of the experience prove the pathogenesis role of the CTD in the development of the CE and creative necessity of the exposure of the CTD’s clinic signs for the correlation, stabilization of the process, and improvement of the operative treatment’s results.

作者简介

D. Kostyuchek

编辑信件的主要联系方式.
Email: info@eco-vector.com
俄罗斯联邦, Saint-Petersburg

А. Klyukovkina

Email: info@eco-vector.com
俄罗斯联邦, Saint-Petersburg

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