The physiological role of vitamin D and the significance of its deficiency in the pathogenesis of climacteric syndrome

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Abstract


This literature review summarizes data on the physiological role of vitamin D in women during menopause. We discuss the peculiarities of climacteric syndrome affected by vitamin D deficiency, including the impact of the vitamin on the central nervous system and its role in cognitive and affective disorders. The necessity of vitamin D therapy to prevent pathologies associated with menopause is highlighted.


Yulia E. Morozova

Women’s Consultation Clinic No 13 affiliated with Saint Petersburg City Outpatient Clinic No 8

Author for correspondence.
Email: moskwicheva.iulia@yandex.ru

Russian Federation, Saint Petersburg

MD

Marina A. Tarasova

Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

Email: tarasova@ott.ru

Russian Federation, Saint Petersburg

MD, PhD, DSci (Medicine), Professor, Honoured Scholar of the Russian Federation

  • Российская ассоциация эндокринологов, ФГБУ «Эндокринологический научный центр». Дефицит витамина D у взрослых: диагностика, лечение и профилактика: Клинические рекомендации. - М., 2015. [Russian Association of endocrinologists, FSU “Endocrinological research center”. Vitamin D deficiency in adults: diagnosis, treatment and prevention. Clinical recommendations. Moscow; 2015. (In Russ.)]
  • Ших Е.В., Милотова Н.М. Роль полиморфизма гена VDR, кодирующего рецептор витамина D, в патогенезе артериальной гипертонии // Биомедицина. - 2009. - Т. 1. - № 1. - С. 55-67. [Shikh EV, Milotova NM. Role of VDR gene polymorphism, encoding vitamin D receptor, in the pathogenesis of arterial hypertension. Biomeditsina. 2009;1(1):55-67. (In Russ.)]
  • Громова О.А., Торшин И.Ю., Джиджихия Л.К. Роли витамина D в профилактике и лечении женского бесплодия // Гинекология. - 2016. - Т. 18. - № 3. - С. 34-39. [Gromova OA, Torshin IY, Dzhidzhikhiya LK. Roles of vitamin D in the prevention and treatment of female infertility. Ginekologiya. 2016;18(3):34-39. (In Russ.)]
  • Kim TH, Lee HH, Kim JM, et al. Expression of Vitamin D receptor in seminal vesicles of cholesterol formula mice. J Menopausal Med. 2015;21(2):89-92. doi: 10.6118/jmm.2015.21.2.89.
  • Kim TH, Lee HH, Park J. Immunohistochemical detection of the 1,25-dihydroxy vitamin D receptor in the human vagina. Iran J Reprod Med. 2014;12(12):805-810.
  • Санкт-Петербургский информационно-аналитический центр. Прогноз значений социально-демографических показателей по Санкт-Петербургу на период до 2021 г. - СПб., 2011. [Saint Petersburg Information and Analytical Center. Forecast of values of socio-demographic indicators for Saint Petersburg for the period up to 2021. Saint Petersburg; 2011. (In Russ.)]
  • Kim M, Kim T-H, Lee H-H, et al. The Role of Vitamin D in menopausal medicine. Kosin Med J. 2016;31(2):97. doi: 10.7180/kmj.2016.31.2.97.
  • Гинекология от пубертата до постменопаузы: практическое руководство для врачей / Под ред. Э.К. Айламазяна. - М.: МЕДпресс-информ, 2007. [Gynecology from pubertal to postmenopausal: a practical guide for physicians. Ed by E.K. Aylamazyan. Moscow: MEDpress-inform; 2007. (In Russ.)]
  • Casper RF, Yen SS. Neuroendocrinology of menopausal flushes: a hypothesis of flush mechanism. Clin Endocrinol (Oxf). 1985;22(3):293-312. doi: 10.1111/j.1365-2265.1985.tb03243.x.
  • Crandall CJ, Tseng CH, Crawford SL, et al. Association of menopausal vasomotor symptoms with increased bone turnover during the menopausal transition. J Bone Miner Res. 2011;26(4):840-849. doi: 10.1002/jbmr.259.
  • Gast GC, Grobbee DE, Pop VJ, et al. Vasomotor symptoms are associated with a lower bone mineral density. Menopause. 2009;16(2):231-238. doi: 10.1097/gme.0b013e318185e25b.
  • Naessen T, Persson I, Ljunghall S, Bergstrom R. Women with climacteric symptoms: a target group for prevention of rapid bone loss and osteoporosis. Osteoporos Int. 1992;2(5):225-231.
  • Rossmanith WG, Ruebberdt W. What causes hot flushes? The neuroendocrine origin of vasomotor symptoms in the menopause. Gynecol Endocrinol. 2009;25(5):303-314. doi: 10.1080/09513590802632514.
  • Cass WA, Smith MP, Peters LE. Calcitriol Protects against the Dopamine- and Serotonin-Depleting Effects of Neurotoxic Doses of Methamphetamine. Send to Ann N Y Acad Sci. 2006;1074(1):261-271. doi: 10.1196/annals.1369.023.
  • LeBlanc ES, Desai M, Perrin N, et al. Vitamin D levels and menopause-related symptoms. Menopause. 2014;21(11):1197-1203. doi: 10.1097/GME.0000000000000238.
  • Polisseni AF, Andrade AT, Ribeiro LC, et al. Effects of a continuous-combined regimen of low-dose hormone therapy (oestradiol and norethindrone acetate) and tibolone on the quality of life in symptomatic postmenopausal women: a double-blind, randomised study. Maturitas. 2013;74(2):172-178. doi: 10.1016/j.maturitas.2012.11.001.
  • Pludowski P, Holick MF, Pilz S, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev. 2013;12(10):976-989. doi: 10.1016/j.autrev.2013.02.004.
  • Badalian SS, Rosenbaum PF. Vitamin D and pelvic floor disorders in women: results from the National Health and Nutrition Examination Survey. Obstet Gynecol. 2010;115(4):795-803. doi: 10.1097/AOG.0b013e3181d34806.
  • Bouzid D, Merzouki S, Bachiri M, et al. Vitamin D3 a new drug against Candida albicans. J Mycol Med. 2017;27(1):79-82. doi: 10.1016/j.mycmed.2016.10.003.
  • Reichrath J. Unravelling of hidden secrets: The role of vitamin D in skin aging. Dermatoendocrinol. 2012;4(3):241-244. doi: 10.4161/derm.21312.
  • Rasheed H, Mahgoub D, Hegazy R, et al. Serum ferritin and vitamin D in female hair loss: do they play a role? Skin Pharmacol Physiol. 2013;26(2):101-107. doi: 10.1159/000346698.
  • Lips P, van Schoor NM. The effect of vitamin D on bone and osteoporosis. Best Pract Res Clin Endocrinol Metab. 2011;25(4):585-591. doi: 10.1016/j.beem.2011.05.002.
  • Kim JS, Choi JY, Lee K, Song IJ, et al. The study in vitamin D concentration in the blood for infants with high level of alkaline phosphatase. Kosin Med J. 2012;27(1):17-24. doi: 10.7180/kmj.2012.27.1.17.
  • Lovejoy JC, Champagne CM, de Jonge L, et al. Increased visceral fat and decreased energy expenditure during the menopausal transition. Int J Obes (Lond). 2008;32(6):949-958. doi: 10.1038/ijo.2008.25.
  • Wehr E, Pilz S, Boehm BO, et al. The lipid accumulation product is associated with increased mortality in normal weight postmenopausal women. Obesity. 2011;19(9):1873-1880. doi: 10.1038/oby.2011.42.
  • Group ECW. Perimenopausal risk factors and future health. Hum Reprod Update. 2011;17(5):706-717. doi: 10.1093/humupd/dmr020.
  • Vimaleswaran KS, Berry DJ, Lu C, et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med. 2013;10(2):e1001383. doi: 10.1371/journal.pmed.1001383.
  • Dong J, Lau CW, Wong SL, Huang Y. Cardiovascular benefits of vitamin D. Sheng Li Xue Bao. 2014;66(1):30-36.
  • Kunutsor SK, Apekey TA, Steur M. Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants. Eur J Epidemiol. 2013;28(3):205-221. doi: 10.1007/s10654-013-9790-2.
  • Vimal Karani S. Genetic research clarifies link between hypertension and Vitamin D deficiency. In: Proceedings of the European Human Genetic Conference; 2013 June 8-11; Paris, France. Paris, 2013.
  • Uemura H, Katsuura-Kamano S, Yamaguchi M, et al. Association between dietary calcium intake and arterial stiffness according to dietary vitamin D intake in men. Br J Nutr. 2014;112(8):1333-1340. doi: 10.1017/S0007114514002153.
  • Genazzani AR, Pluchino N, Luisi S, Luisi M. Estrogen, cognition and female ageing. Hum Reprod Update. 2007;13(2):175-187. doi: 10.1093/humupd/dml042.
  • Dhir A, Kulkarni SK. Antidepressant-like effect of 17beta-estradiol: involvement of dopaminergic, serotonergic, and (or) sigma-1 receptor systems. Can J Physiol Pharmacol. 2008;86(10):726-735. doi: 10.1139/y08-077.
  • Begliuomini S, Casarosa E, Pluchino N, et al. Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor. Hum Reprod. 2007;22(4):995-1002. doi: 10.1093/humrep/del479.
  • Vegeto E, Benedusi V, Maggi A. Estrogen anti-inflammatory activity in brain: a therapeutic opportunity for menopause and neurodegenerative diseases. Front Neuroendocrinol. 2008;29(4):507-519. doi: 10.1016/j.yfrne.2008.04.001.
  • Bromberger JT, Harlow S, Avis N, et al. Racial/ethnic differences in the prevalence of depressive symptoms among middle-aged women: The Study of Women’s Health Across the Nation (SWAN). Am J Public Health. 2004;94(8):1378-1385. doi: 10.2105/AJPH.94.8.1378.
  • Freeman EW, Sammel MD, Lin H, Nelson DB. Associations of hormones and menopausal status with depressed mood in women with no history of depression. Arch Gen Psychiatry. 2006;63(4):375-382. doi: 10.1001/archpsyc.63.4.375.
  • Mortel KF, Meyer JS. Lack of postmenopausal estrogen replacement therapy and the risk of dementia. The J Neuropsychiatry Clin Neurosci. 1995;7(3):334-337. doi: 10.1176/jnp.7.3.334.
  • Wharton W, Gleason CE, Olson SR, et al. Neurobiological Underpinnings of the Estrogen - Mood Relationship. Curr Psychiatry Rev. 2012;8(3):247-256. doi: 10.2174/157340012800792957.
  • Pludowski P, Holick MF, Pilz S, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality - a review of recent evidence. Autoimmun Rev. 2013;12(10):976-989. doi: 10.1016/j.autrev.2013.02.004.
  • Buell JS, Dawson-Hughes B, Scott TM, et al. 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology. 2010;74(1):18-26. doi: 10.1212/WNL.0b013e3181beecb7.
  • Eyles DW, Burne TH, McGrath JJ. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front Neuroendocrinol. 2013;34(1):47-64. doi: 10.1016/j.yfrne.2012.07.001.
  • Дорофейков В.В., Задорожная М.С., Петрова Н.Н. Депрессия и витамин D // Психиатрия. - 2014. - № 2. - C. 84-90. [Dorofeykov VV, Zadorozhnaya MS, Petrova NN. Depression and vitamin D. Psychiatry. 2014;(2):84-90. (In Russ.)]
  • Shivakumar V, Kalmady SV, Amaresha AC, et al. Serum vitamin D and hippocampal gray matter volume in schizophrenia. Psychiatry Res. 2015;233(2):175-179. doi: 10.1016/j.pscychresns.2015.06.006.
  • Bener A, Saleh NM. Low vitamin D, and bone mineral density with depressive symptoms burden in menopausal and postmenopausal women. J Midlife Health. 2015;6(3):108-114. doi: 10.4103/0976-7800.165590.
  • Okereke OI, Singh A. The role of vitamin D in the prevention of late-life depression. J Affect Disord. 2016;198:1-14. doi: 10.1016/j.jad.2016.03.022.
  • Pettersen JA, Fontes S, Duke CL. The effects of Vitamin D Insufficiency and Seasonal Decrease on cognition. Can J Neurol Sci. 2014;41(4):459-465. doi: 10.1017/S0317167100018497.
  • Shen L, Ji HF. Vitamin D deficiency is associated with increased risk of Alzheimer’s disease and dementia: evidence from meta-analysis. Nutr J. 2015;14:76. doi: 10.1186/s12937-015-0063-7.
  • Purdue-Smithe AC, Whitcomb BW, Szegda KL, et al. Vitamin D and calcium intake and risk of early menopause. Am J Clin Nutr. 2017;105(6):1493-1501. doi: 10.3945/ajcn.116.145607.
  • Buchanan JR, Santen R, Cauffman S, et al. The effect of endogenous estrogen fluctuation on metabolism of 25-hydroxyvitamin D. Calcif Tissue Int. 1986;39(3):139-144. doi: 10.1007/BF02555109.
  • Heaney RP, Davies KM, Chen TC, et al. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003;77(1):204-210. doi: 10.1093/ajcn/77.1.204.
  • Лесняк О.М., Никитинская О.А., Торопцова Н.В., и др. Профилактика, диагностика и лечение дефицита витамина D и кальция у взрослого населения России и пациентов с остеопорозом (по материалам подготовленных клинических рекомендаций) // Научно-практическая ревматология. - 2015. - Т. 53. - № 4. - С. 403-408. [Lesnyak OM, Nikitinskaya OA, Toroptsova NV, et al. The prevention, diagnosis, and treatment of vitamin D and calcium deficiencies in the adult population of Russia and in patients with osteoporosis (according to the materials of prepared clinical recommendations). Science-Practical Rheumatology. 2015;53(4):403-408. (In Russ.)]

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