Indices of the natural killer cells cytotoxic activity and interferon values in patients with uterine myoma

Abstract

Objective: The state of the system of immunological is of great importance for pathogenesis of uterine myoma as of any process of tumors growth.

Full Text

Methods: 56 patients were examined to study their clinical and laboratory data, total serum interferon, the ability of peripheral blood leukocytes to synthesize a/b and g-interferon, cytotoxic activity of natural killer cells.

Results: the cytotoxic activity of natural killer was low in 27% of women, and all of them had either fast growth of the uterine myoma (with nodes more than 5 cm in diameter) or myoma recurrence after myomectomy. High positive correlation was found between the patients age and the ability of peripheral blood leukocytes to produce g-interferon (correlation coefficient = 0,44), between the size of a myomatic node and indices of the functional activity of natural killers (c.c. = 0,35), between the ability of peripheral blood leukocytes to produce a/b-interferon and functional activity of natural killer cells (c.c. = 0,32)

 Conclusion: So, the growth of uterine myoma can be predicted indirectly by the showings of cytotoxic activity of natural killer cells and by the ability of peripheral blood leukocytes to produce g-interferon.