Email this article Giant uterine fibroids with chromosome 22 monosomy. A clinical case
- Authors: Yarmolinskaya M.I.1, Tsypurdeeva A.A.1, Polenov N.I.1, Malysheva O.V.1, Koltsova A.S.1, Pendina A.A.1, Efimova O.A.1, Osinovskaya N.S.1, Shved N.Y.1
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Affiliations:
- The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- Issue: Vol 72, No 3 (2023)
- Pages: 117-125
- Section: Theory and Practice
- Submitted: 03.05.2023
- Accepted: 12.05.2023
- Published: 14.07.2023
- URL: https://journals.eco-vector.com/jowd/article/view/375307
- DOI: https://doi.org/10.17816/JOWD375307
- ID: 375307
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Abstract
We present a clinical case of giant uterine fibroids in this research, with the peculiarity of surgical treatment and the course of the postoperative period described. A series of genetic studies specific to uterine fibroids was performed, namely, mutations in the MED12 gene, overexpression of the HMGA2 gene, and chromosomal imbalance. We did not detect mutations of exon 2 of the MED12 gene and an increase in the expression of the HMGA2 gene in the patient’s myomatous node sample. The molecular karyotype arr(22)×1 (chromosome 22 monosomy) was established by comparative genomic hybridization in the tissue of giant uterine fibroids.
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About the authors
Maria I. Yarmolinskaya
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: m.yarmolinskaya@gmail.com
ORCID iD: 0000-0002-6551-4147
SPIN-code: 3686-3605
Scopus Author ID: 7801562649
ResearcherId: P-2183-2014
MD, Dr. Sci. (Med.), Professor, Professor of the Russian Academy of Sciences
Russian Federation, Saint PetersburgAnna A. Tsypurdeeva
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: tsypurdeevan@mail.ru
ORCID iD: 0000-0001-7774-2094
SPIN-code: 5208-9707
MD, Cand. Sci. (Med.)
Russian Federation, Saint PetersburgNikolai I. Polenov
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Author for correspondence.
Email: polenovdoc@mail.ru
ORCID iD: 0000-0001-8575-7026
SPIN-code: 9387-1703
MD, Cand. Sci. (Med.)
Russian Federation, Saint PetersburgOlga V. Malysheva
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: omal99@mail.ru
ORCID iD: 0000-0002-8626-5071
SPIN-code: 1740-2691
Scopus Author ID: 6603763549
ResearcherId: O-9897-2014
Cand. Sci. (Biol.)
Russian Federation, Saint PetersburgAlla S. Koltsova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: rosenrot15@yandex.ru
ORCID iD: 0000-0002-6587-9429
SPIN-code: 3038-4096
Scopus Author ID: 57189621865
ResearcherId: O-1814-2017
Russian Federation, Saint Petersburg
Anna A. Pendina
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: pendina@mail.ru
ORCID iD: 0000-0001-9182-9188
SPIN-code: 3123-2133
Scopus Author ID: 6506976983
ResearcherId: F-4396-2017
Cand. Sci. (Biol.)
Russian Federation, Saint PetersburgOlga A. Efimova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: efimova_o82@mail.ru
ORCID iD: 0000-0003-4495-0983
SPIN-code: 6959-5014
Scopus Author ID: 14013324600
ResearcherId: F-5764-2014
Cand. Sci. (Biol.)
Russian Federation, Saint PetersburgNatalia S. Osinovskaya
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: natosinovskaya@mail.ru
ORCID iD: 0000-0001-7831-9327
SPIN-code: 3190-2307
Scopus Author ID: 6507794800
ResearcherId: K-1168-2018
Cand. Sci. (Biol.)
Russian Federation, Saint PetersburgNatalia Yu. Shved
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: natashved@mail.ru
ORCID iD: 0000-0001-6354-9226
SPIN-code: 8276-1720
Cand. Sci. (Biol.)
Russian Federation, Saint PetersburgReferences
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