Thromboelastography for optimizing the diagnosis and management of abnormal uterine bleeding

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Abstract

A comprehensive literature review was conducted on the use of thromboelastography in the diagnosis and treatment of abnormal uterine bleeding. Thromboelastography is a highly informative method for assessing blood coagulation properties, enabling a detailed analysis of all stages of hemostasis, including clot formation dynamics, clot strength, and the efficiency of fibrinolytic processes, thereby providing a comprehensive evaluation of the coagulation system. During and after the COVID-19 pandemic, the importance of thromboelastography has increased significantly as it facilitates the detection of hypercoagulable states, which is critical for patients at high risk of thrombosis. Despite the limited use of thromboelastography in routine clinical practice, its potential in the diagnosis and monitoring of coagulopathies, particularly in conditions of increased thrombosis, makes this method a valuable addition to traditional coagulation tests. The use of thromboelastography enhances the diagnostic capabilities in abnormal uterine bleeding by not only identifying coagulation abnormalities, but also differentiating their underlying pathophysiological mechanisms. This is particularly important in cases where standard diagnostic and therapeutic approaches prove ineffective, as well as in patients with combined coagulopathies who require a personalized treatment strategy.

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About the authors

Aliya Yu. Kurmangaleeva

Morozovskaya Children’s City Clinical Hospital, the Moscow City Health Department; Pirogov Russian National Research Medical University

Email: askarova-aliya@yandex.ru
ORCID iD: 0000-0002-2348-1607
SPIN-code: 2739-8291
Russian Federation, Moscow; Moscow

Elena V. Sibirskaya

Morozovskaya Children’s City Clinical Hospital, the Moscow City Health Department; Pirogov Russian National Research Medical University; Russian Children’s Clinical Hospital, Pirogov Russian National Research Medical University; Russian University of Medicine

Email: elsibirskaya@yandex.ru
ORCID iD: 0000-0002-4540-6341
SPIN-code: 1356-9252

MD, Dr. Sci. (Medicine), Assistant Professor

Russian Federation, Moscow; Moscow; Moscow; Moscow

Irina V. Karachentsova

Pirogov Russian National Research Medical University; Russian Children’s Clinical Hospital, Pirogov Russian National Research Medical University

Author for correspondence.
Email: 5053104@list.ru
ORCID iD: 0000-0002-0254-690X
SPIN-code: 6520-9747

MD, Cand. Sci. (Medicine), Assistant Professor

Russian Federation, Moscow; Moscow

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия Эл № 77 - 6389 от 15.07.2002 г.