Email this article The role of sonography and hysteroscopy in endometrial evaluation in postmenopausal women used antiestrogens
- Authors: Ashrafyan L.A.1, Antonova I.В.1, Mockobili Т.А.1, Chazova N.L.1, Babaeva N.А.1, Basova I.O.1
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Affiliations:
- Russian Radiological Scientific Centre
- Issue: Vol 54, No 5S (2005)
- Pages: 79-80
- Section: Reviews
- Submitted: 15.11.2005
- Accepted: 10.11.2021
- Published: 15.11.2005
- URL: https://journals.eco-vector.com/jowd/article/view/87518
- DOI: https://doi.org/10.17816/JOWD87518
- ID: 87518
Cite item
Abstract
Background: it’s known that antiestrogens and tamoxifen in the first instance display some level of estrogen activity.
Full Text
Background: it’s known that antiestrogens and tamoxifen in the first instance display some level of estrogen activity. The study of agonistic effect realization has taken attention to the action of this medication in other target organs including endometrium.
Materials and methods. The results of clinical observations of 276 postmenopausal patients with breast cancer used or not used tamoxifen were presented. All patients were undergone ultrasound exam with M-echo measurement that was accompanied by hysteroscopy and endometrial biopsy in case of the M-echo increased more than 5 mm.
Results. Data analysis revealed real increasing of number of patients used tamoxifen with more than 5 mm M-echo. But hysteroscopy showed endometrial changes only at 27,7% of these patients. The rest women has signs of atrophy.
Conclusion. The tamoxifen influence on uterine developes as increased proliferation of stromal component and basal layer hyperplasia. These processes manifest by M-echo increasing, hysteroscopy shows atrophy. The wide using of hysteroscopy with endometrial biopsy allows to provide confirm and early diagnostics of endometrial cancer.
About the authors
L. A. Ashrafyan
Russian Radiological Scientific Centre
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Moscow
I. В. Antonova
Russian Radiological Scientific Centre
Email: info@eco-vector.com
Russian Federation, Moscow
Т. А. Mockobili
Russian Radiological Scientific Centre
Email: info@eco-vector.com
Russian Federation, Moscow
N. L. Chazova
Russian Radiological Scientific Centre
Email: info@eco-vector.com
Russian Radiological Scientific Centre
Russian Federation, MoscowN. А. Babaeva
Russian Radiological Scientific Centre
Email: info@eco-vector.com
Russian Federation, Moscow
I. O. Basova
Russian Radiological Scientific Centre
Email: info@eco-vector.com
Russian Federation, Moscow
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