Diagnostic and correction treatment of male immune infertility

Abstract

Objective: Study of immune causes of male infertility and new treatment methods is one of the main directions in andrology.

Full Text

Methods: A total of 378 men of infertile couples was examined according WHO criteria (WHO, 1992). A mixed antiglobulin reaction (direct MAR-test (Belgium)) for immunoglobulin IgG was performed on all samples to detect the presence of antisperm antibodies (ASA). This test was considered positive if more than 10% of spermatozoa demonstrated immunoglobulin attachment. The double-blind treatment was performed during 3 months with 120-mg/day testosterone undecanoate (Netherlands).

Results: Our study detected the immune factor in 15,8% that often went with asthenozoospermia (57,1%) and hypoandrogenia (23,4%). The patients with ASA<60% showed the decrease of MAR-test results until 10-15% after androgen treatment. The patients with ASA 60-100% need the assisted reproduction treatment procedures.

Conclusion: The use of androgen therapy in treatment of male immune infertility is perspective direction and needs further study.