Diagnostic and correction treatment of male immune infertility
- Authors: Ter-Avanesov G.V.1, Kulakov V.I.1, Goloubeva E.L.1, Korotkova I.V.1
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Affiliations:
- Russian Scientific Center for Gynecology, Obstetrics and Perinatology
- Issue: Vol 48, No 5S (1999)
- Pages: 159-159
- Section: Articles
- URL: https://journals.eco-vector.com/jowd/article/view/101461
- DOI: https://doi.org/10.17816/JOWD101461
- ID: 101461
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Abstract
Objective: Study of immune causes of male infertility and new treatment methods is one of the main directions in andrology.
Full Text
Objective: Study of immune causes of male infertility and new treatment methods is one of the main directions in andrology.
Methods: A total of 378 men of infertile couples was examined according WHO criteria (WHO, 1992). A mixed antiglobulin reaction (direct MAR-test (Belgium)) for immunoglobulin IgG was performed on all samples to detect the presence of antisperm antibodies (ASA). This test was considered positive if more than 10% of spermatozoa demonstrated immunoglobulin attachment. The double-blind treatment was performed during 3 months with 120-mg/day testosterone undecanoate (Netherlands).
Results: Our study detected the immune factor in 15,8% that often went with asthenozoospermia (57,1%) and hypoandrogenia (23,4%). The patients with ASA<60% showed the decrease of MAR-test results until 10-15% after androgen treatment. The patients with ASA 60-100% need the assisted reproduction treatment procedures.
Conclusion: The use of androgen therapy in treatment of male immune infertility is perspective direction and needs further study.
About the authors
G. V. Ter-Avanesov
Russian Scientific Center for Gynecology, Obstetrics and Perinatology
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Moscow
V. I. Kulakov
Russian Scientific Center for Gynecology, Obstetrics and Perinatology
Email: info@eco-vector.com
Russian Federation, Moscow
E. L. Goloubeva
Russian Scientific Center for Gynecology, Obstetrics and Perinatology
Email: info@eco-vector.com
Russian Federation, Moscow
I. V. Korotkova
Russian Scientific Center for Gynecology, Obstetrics and Perinatology
Email: info@eco-vector.com
Russian Federation, Moscow