Antimicrobial peptides in the pathogenesis of infectious complications in obstetrics and gynecology

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Abstract

Antimicrobial peptides (AMP) are cationic peptides of innate immune system with antiviral, antibacterial and antiprotozoal activity. AMP act as immunomodulators, promote bacterial opsonization, inhibit proteases activity, have anti-endotoxic and angiogenic effect. The review describes main types of AMPs, features of their expression in female reproductive tract depending from menstrual cycle and during pregnancy. Data about the role of AMPs in defending from sexually transmitted infections (HIV, genital herpes, HPV, gonorrhea), in pathogenesis of extrauterine pregnancy and preterm birth are described. Possibility of practical application of AMPs as alternative to antibiotics and as contraceptives is estimated.

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About the authors

Olesya Nikolaevna Ivashova

Belgorod State National Research University

Email: ivashovao2@yandex.ru
MD, postgraduate student of the department of obstetrics and gynaecology

Olga Petrovna Lebedeva

Belgorod State National Research University

Email: safonova2@yandex.ru
MD, PhD, associate professor of the department of obstetrics and gynaecology

Sergey Petrovich Pakhomov

Belgorod State National Research University

Email: pachomw@yandex.ru
MD, PhD, professor, head of the department of obstetrics and gynaecology

Natal’ya Alexandrovna Rudyh

Belgorod State National Research University

Email: rudyh@bsu.edu.ru
MD, PhD, associate professor of the department of medical biology

Marina Sergeevna Seliverstova

Belgorod State National Research University

Email: seliverstovams@yandex.ru
MD, an assistant of the department of propaedevtics of internal diseases and clinical information technologies

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Copyright (c) 2014 Ivashova O.N., Lebedeva O.P., Pakhomov S.P., Rudyh N.A., Seliverstova M.S.

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 66759 от 08.08.2016 г. 
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия Эл № 77 - 6389 от 15.07.2002 г.


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