Experimental study of the sensitivity pregnant and nonpregnant uterus to the bradykinin and parmidin

详细

Objective. The purpose of the present study was to examine the sensitivity of isolated nonpregnant and pregnant rat uterus to spasmogenic action of bradykinin and effect of antibradykinin agent - pyridonolcarbamat (Parmidin).

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Methods. Nonpregnant and pregnant (in I, II and III periods of normal pregnancy) rats Wistar line were used for investigations.

Results. It was showed that sensitivity of pregnant uterus to the bradykinin increased as nonpregnant uterus especially during I and III periods of pregnancy. Parmidin antagonizes bradykinin - induced contractions in rat isolated uterus and its effect correlated with changes of sensitivity of the uterus to bradykinin.

Conclusions. According to our reckoning parmidin it is possible to recommend for complex treatment of abnormal labor activity. Clinical approbations are necessary for using this drug in obstetrics.