Premedication of pregnant women at risk of developing abnormal labor activity with vasoactive and metabocally active substances

详细

Objective: To study the efficiency of Instenon (preparation consisting of 3 substances possessing vasoactive and metabolically active properties: ethophylline, hexobendine and etamivane) used for antepartum preparing pregnant women of a risk group for the development of abnormal labor activity.

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Methods: Preparation for labor with Instenon was carried out in 52 pregnant women. The women underwent cardiotocography, hysterography, ultrasonography, dopplerometry and intrapartum fetal ECG. Statistical reliability was determined using Student’s t-test.

Results: The administration of Instenon as a means of preparation for labor resulted in an improvement of structural changes of the cervix, a significant decrease in the frequency of abnormal labor activity, total duration of labor, percentage of surgical delivery, maternal traumatism and of blood loss amount in labor. All newborns had high Apgar score (7 to 9).

Conclusions: The experience of clinical using Instenon testifies its high efficiency in the antepartum preparing of pregnant women with the high risk of development of abnormal labor activity.