Correlation of serum cytokine determination with pregnancy outcome in women with habitual abortions
- 作者: Sidelnikova V.M.1, Tetrouachvili N.K.1, Sukhikh G.T.1
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隶属关系:
- Research Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences
- 期: 卷 48, 编号 5S (1999)
- 页面: 148-148
- 栏目: Articles
- ##submission.dateSubmitted##: 22.02.2022
- ##submission.dateAccepted##: 22.02.2022
- ##submission.datePublished##: 15.12.1999
- URL: https://journals.eco-vector.com/jowd/article/view/101432
- DOI: https://doi.org/10.17816/JOWD101432
- ID: 101432
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Objective: To test the hypothesis that disturbance of the cytokine balance during human pregnancy may initiate spontaneous abortion.
全文:
Objective: To test the hypothesis that disturbance of the cytokine balance during human pregnancy may initiate spontaneous abortion.
Methods: Levels of interleukin-6 (IL-6), interferon-gamma (IFN-g), tumor necrosis factor-alpha (TNF-a) and interleukin-4 (IL-4) were measured by enzyme-linked immunosorbent assay (ELISA) in sera from 46 women with a history of two or more prior pregnancy losses (main group). Control group consisted of 20 healthy women with first normal pregnancy.
Results: In main group abortions were observed in 11/46 (23,9%) women, 6/46 (13%) pregnancies terminated as preterm labor on 28-34 weeks, in two cases with premature partial placental separation. TNF-a levels were demonstrable in sera of 10/11 women with missed abortions and were 20 times higher than in control group. Normalization of TNF-a and IFN-g levels was associated with regress of symptoms of threatened abortion in main group. Increase of IL-6 levels in first trimester of pregnancy were determinate in cases of abruption of chorion villi and clinical signs of infection.
Conclusion: Statistically significant increased production of TNF-a, IL-6, IFN-g and reduced production of IL-4 characterized threatened abortion group and distinguished them from normal pregnancies. These preliminary data suggest that disturbance of the cytokine balance could play a significant role in the mechanisms of immunologically mediated recurrent pregnancy loss.
作者简介
V. Sidelnikova
Research Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences
编辑信件的主要联系方式.
Email: info@eco-vector.com
俄罗斯联邦, Moscow
N. Tetrouachvili
Research Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences
Email: info@eco-vector.com
俄罗斯联邦, Moscow
G. Sukhikh
Research Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences
Email: info@eco-vector.com
俄罗斯联邦, Moscow