Correlation of serum cytokine determination with pregnancy outcome in women with habitual abortions
- Authors: Sidelnikova V.M.1, Tetrouachvili N.K.1, Sukhikh G.T.1
-
Affiliations:
- Research Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences
- Issue: Vol 48, No 5S (1999)
- Pages: 148-148
- Section: Articles
- URL: https://journals.eco-vector.com/jowd/article/view/101432
- DOI: https://doi.org/10.17816/JOWD101432
- ID: 101432
Cite item
Full Text
Abstract
Objective: To test the hypothesis that disturbance of the cytokine balance during human pregnancy may initiate spontaneous abortion.
Full Text
Objective: To test the hypothesis that disturbance of the cytokine balance during human pregnancy may initiate spontaneous abortion.
Methods: Levels of interleukin-6 (IL-6), interferon-gamma (IFN-g), tumor necrosis factor-alpha (TNF-a) and interleukin-4 (IL-4) were measured by enzyme-linked immunosorbent assay (ELISA) in sera from 46 women with a history of two or more prior pregnancy losses (main group). Control group consisted of 20 healthy women with first normal pregnancy.
Results: In main group abortions were observed in 11/46 (23,9%) women, 6/46 (13%) pregnancies terminated as preterm labor on 28-34 weeks, in two cases with premature partial placental separation. TNF-a levels were demonstrable in sera of 10/11 women with missed abortions and were 20 times higher than in control group. Normalization of TNF-a and IFN-g levels was associated with regress of symptoms of threatened abortion in main group. Increase of IL-6 levels in first trimester of pregnancy were determinate in cases of abruption of chorion villi and clinical signs of infection.
Conclusion: Statistically significant increased production of TNF-a, IL-6, IFN-g and reduced production of IL-4 characterized threatened abortion group and distinguished them from normal pregnancies. These preliminary data suggest that disturbance of the cytokine balance could play a significant role in the mechanisms of immunologically mediated recurrent pregnancy loss.
About the authors
V. M. Sidelnikova
Research Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Moscow
N. K. Tetrouachvili
Research Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences
Email: info@eco-vector.com
Russian Federation, Moscow
G. T. Sukhikh
Research Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences
Email: info@eco-vector.com
Russian Federation, Moscow