Serum lipoprotein changes in women over the age of 35 years using combined oral contraceptives
- 作者: Tarasova M.A.1,2, Soukhorukova A.V.1,2, Bodul A.S.1,2
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隶属关系:
- I.P. Pavlov Medical University
- D.O. Ott Institute of Obstetrics & Gynecology
- 期: 卷 48, 编号 5S (1999)
- 页面: 157-157
- 栏目: Articles
- ##submission.dateSubmitted##: 22.02.2022
- ##submission.dateAccepted##: 22.02.2022
- ##submission.datePublished##: 15.12.1999
- URL: https://journals.eco-vector.com/jowd/article/view/101453
- DOI: https://doi.org/10.17816/JOWD101453
- ID: 101453
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全文:
详细
The reduction of steroid dose has led to the increase in safety of combined oral contraceptives (COCs) use. Since then modern “low-dose” formulations of COCs have been widely recommended not only for young women but also for women of late reproductive age.
全文:
The reduction of steroid dose has led to the increase in safety of combined oral contraceptives (COCs) use. Since then modern “low-dose” formulations of COCs have been widely recommended not only for young women but also for women of late reproductive age.
Objective: To evaluate the effect of two COC formulations (30 g ethinylestradiol with 300 g norgestrel and 20 g ethinylestradiol with 150 g desogestrel) on serum levels of lipoproteins and apoproteins in women over the age of 35 years.
Methods: 45 women within the age interval of 35-49 years were enrolled in the study. Measurement of lipoproteins and apolipoproteins-Al and apolipoproteins-В was performed at the commencement of the study and after 6 cycles of COCs use.
Results: There was a significant reduction in serum cholesterol and LDL-cholesterol levels in both groups. The coefficient of atherogenesis was decreased in both groups as well. There was a significant increase in HDL and apoprotein-Al serum levels in women who used COC with 20 g ethinylestradiol and 150 g desogestrel (1,77±0,15 and 1,40±0,11 mmol/l; p<0,05 and 2,37±0,14 and 1,87±0,15 g/l; p<0,05 respectively). No increase in triglycerides was detected in this group (1,46±0,19 and 1,45±0,15 mmol/l).
Conclusions: COC formulation with 20 g ethinylestradiol and 150 g desogestrel has more beneficial effect on antiatherogenic lipoprotein profile as compared to COC formulation with 30 g ethinylestradiol and norgestrel as a progestagen component.
作者简介
M. Tarasova
I.P. Pavlov Medical University; D.O. Ott Institute of Obstetrics & Gynecology
编辑信件的主要联系方式.
Email: info@eco-vector.com
俄罗斯联邦, St. Petersburg; St. Petersburg
A. Soukhorukova
I.P. Pavlov Medical University; D.O. Ott Institute of Obstetrics & Gynecology
Email: info@eco-vector.com
俄罗斯联邦, St. Petersburg; St. Petersburg
A. Bodul
I.P. Pavlov Medical University; D.O. Ott Institute of Obstetrics & Gynecology
Email: info@eco-vector.com
俄罗斯联邦, St. Petersburg; St. Petersburg