Chemoprevention as a way to control epigenetic changes (Analytical review of the literature)

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Epigenetic alterations have been identified as promising new targets for cancer prevention strategies as they occur early during carcinogenesis. Therapy is mainly focused on reversion of DNA methylation by inhibiting DNA-methyltransferases and low level of acetylated histones by inhibiting histone deacetylases. DIM and epigallocatechin-3-gallate (EGCG) substances are believed to be an anticancer agent in part through its regulation of epigenetic processes. These agents demonstrate efficacy in cancer chemopreventive action and have potential to be used to current cancer therapies.

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作者简介

Vsevolod Kiselev

National Research Centre (NRC) “Kurchatov Institute”

Email: vkis10@mail.ru

Lev Ashrafyan

Russian Scientific Center of Roentgenoradiology (RSCRR)

Email: levaa2004@yahoo.com

Vitaliy Bezhenar

D. O. Ott Research Institute of Obstetrics and Gynecology

Email: bez-vitaly@yandex.ru

Anna Tsypurdeyeva

D. O. Ott Research Institute of Obstetrics and Gynecology

Email: iagmail@ott.ru

参考

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия Эл № 77 - 6389 от 15.07.2002 г.


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