电邮这篇文章 Evaluation of aromatase expression in endometrioid heterotopias and endometria in patients with external genital endometriosis
- 作者: Malysheva O.V.1, Molotkov A.S.1, Shved N.Y.1, Mikhailova M.A.1, Yarmolinskaya M.I.1
-
隶属关系:
- The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- 期: 卷 72, 编号 5 (2023)
- 页面: 39-47
- 栏目: Original Research
- URL: https://journals.eco-vector.com/jowd/article/view/568877
- DOI: https://doi.org/10.17816/JOWD568877
- ID: 568877
如何引用文章
开放存取
##reader.subscriptionAccessGranted##
详细
BACKGROUND: External genital endometriosis is a multifactorial estrogen-dependent disease. Local estrogen production due to aromatase activity can play an important role in its pathogenesis, so aromatase inhibitors are considered promising drugs for the treatment of the disease. However, the data on their effectiveness are contradictory.
AIM: The aim of this study was to evaluate the expression level of the aromatase-encoding CYP19A1 gene in the eutopic endometrium and endometrioid heterotopies of patients with endometriosis and in the eutopic endometrium of women from the comparison group.
MATERIALS AND METHODS: This study included 79 women. The main group consisted of 55 patients with endometriosis, and 24 patients without endometriosis formed a comparison group. All of the patients underwent an endometrial biopsy during surgery, with excision of endometriotic lesions performed in patients with endometriosis. CYP19A1 gene expression was studied using reverse transcription real-time polymerase chain reaction.
RESULTS: The data obtained confirm a high level of aromatase expression in endometriosis foci. On average, aromatase expression is increased in the eutopic endometrium of patients with endometriosis when compared to the endometrium of women in the comparison group. However, in a significant number of patients with endometriosis, aromatase is expressed in the endometrium at a low level. We did not find an association of increased aromatase expression with any clinical and anamnestic features of the studied group of women, in particular, with infertility, pain syndrome, prevalence of endometriosis, or relapses of the disease.
CONCLUSIONS: Our findings highlight the heterogeneity of endometriosis and may account for the variable effectiveness of hormone-modulating therapy, in particular aromatase inhibitors.
全文:
作者简介
Olga Malysheva
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: omal99@mail.ru
ORCID iD: 0000-0002-8626-5071
SPIN 代码: 1740-2691
Cand. Sci. (Biol.)
俄罗斯联邦, Saint PetersburgArsenii Molotkov
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: arseny.molotkov@gmail.com
ORCID iD: 0000-0003-3433-3092
SPIN 代码: 6359-6472
MD, Cand. Sci. (Med.)
俄罗斯联邦, Saint PetersburgNatalia Shved
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: natashved@mail.ru
ORCID iD: 0000-0001-6354-9226
SPIN 代码: 8276-1720
Cand. Sci. (Biol.)
俄罗斯联邦, Saint PetersburgMarina Mikhailova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: mmikh020@gmail.com
ORCID iD: 0009-0001-5828-2245
俄罗斯联邦, Saint Petersburg
Maria Yarmolinskaya
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
编辑信件的主要联系方式.
Email: m.yarmolinskaya@gmail.com
ORCID iD: 0000-0002-6551-4147
SPIN 代码: 3686-3605
MD, Dr. Sci. (Med.), Professor, Professor of the Russian Academy of Sciences
俄罗斯联邦, Saint Petersburg参考
- Bulun SE, Yilmaz BD, Sison C, et al. Endometriosis. Endocr Rev. 2019;40(4):1048–1079. doi: 10.1210/er.2018-00242
- Shafrir AL, Martel E, Missmer SA, et al. Pelvic floor, abdominal and uterine tenderness in relation to pressure pain sensitivity among women with endometriosis and chronic pelvic pain. Eur J Obstet Gynecol Reprod Biol. 2021;264:247–253. doi: 10.1016/j.ejogrb.2021.07.029
- Vsemirnaya organizatsiya zdravookhraneniya [Internet]. Endometrioz. (In Russ.) [cited 2023 Apr 17]. Available from: https://www.who.int/news-room/fact-sheets/detail/endometriosis
- Nnoaham KE, Hummelshoj L, Webster P, et al. Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil Steril. 2011;96(2):366–373.e8. doi: 10.1016/j.fertnstert.2011.05.090.
- Sampson JA. Metastatic or embolic endometriosis, due to the menstrual dissemination of endometrial tissue into the venous circulation. Am J Pathol. 1927;3(2):93–110.43.
- Yarmolinskaya MI, Aylamazyan EK. Genital’nyy endometrioz. Razlichnye grani problemy. Saint Petersburg: Eco-Vector; 2017. (In Russ.)
- Kitawaki J, Kado N, Ishihara H, et al. Endometriosis: the pathophysiology as an estrogen-dependent disease. J Steroid Biochem Mol Biol. 2002;83(1–5):149–55. doi: 10.1016/s0960-0760(02)00260-1
- Corbin CJ, Graham-Lorence S, McPhaul M, et al. Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells. Proc Natl Acad Sci USA. 1988;85(23):8948–8952. doi: 10.1073/pnas.85.23.8948
- Simpson ER, Mahendroo MS, Means GD, et al. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr Rev. 1994;15(3):342–355. doi: 10.1210/edrv-15-3-342
- Kitawaki J, Noguchi T, Amatsu T, et al. Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium. Biol Reprod. 1997;57(3):514–519. doi: 10.1095/biolreprod57.3.514
- Noble LS, Simpson ER, Johns A, et al. Aromatase expression in endometriosis. J Clin Endocrinol Metab. 1996;81(1):174–179. doi: 10.1210/jcem.81.1.8550748
- Noble LS, Takayama K, Zeitoun KM, et al. Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells. J Clin Endocrinol Metab. 1997;82(2):600–606. doi: 10.1210/jcem.82.2.3783
- Mori T, Ito F, Koshiba A, et al. Aromatase as a target for treating endometriosis. J Obstet Gynaecol Res. 2018;44(9):1673–1681. doi: 10.1111/jog.13743
- Maia H, Haddad C, Casoy J. Correlation between aromatase expression in the eutopic endometrium of symptomatic patients and the presence of endometriosis. Int J Womens Health. 2012;4:61–65. doi: 10.2147/IJWH.S29154
- Hatok J, Zubor P, Galo S, et al. Endometrial aromatase mRNA as a possible screening tool for advanced endometriosis and adenomyosis. Gynecol Endocrinol. 2011;27(5):331–336. doi: 10.3109/09513590.2010.491925
- Taylor RN, Hummelshoj L, Stratton P, et al. Pain and endometriosis: Etiology, impact, and therapeutics. Middle East Fertil Soc J. 2012;17(4):221–225. doi: 10.3109/09513590.2010.491925
- Pavone ME, Bulun SE. Aromatase inhibitors for the treatment of endometriosis. Fertil Steril. 2012;98(6):1370–1379. doi: 10.1016/j.fertnstert.2012.08.053
- Attar E, Bulun SE. Aromatase inhibitors: the next generation of therapeutics for endometriosis? Fertil Steril. 2006;85(5):1307–1318. doi: 10.1016/j.fertnstert.2005.09.064
- Yarmolinskaya MI, Abashova EI, Misharina EV, et al. Medikamentoznaya terapiya genital’nogo endometrioza: realii i perspektivy: rukovodstvo dlya vrachey. Moscow: GEOTAR-Media; 2021. (In Russ.)
- Patent Russian Federation na izobretenie No. 2541089/10.02.2015. Byul. No. 4. Yarmolinskaya MI, Molotkov AS, Bezhenar’ VF. Sposob kompleksnogo lecheniya naruzhnogo genital’nogo endometrioza. (In Russ.) [cited 2023 Sep 12]. Available from: https://viewer.rusneb.ru/ru/000224_000128_0002541089_20150210_C1_RU?page=1&rotate=0&theme=white
- Becker CM, Bokor A, Heikinheimo O, et al. ESHRE guideline: endometriosis. Hum Reprod Open. 2022;2022(2). doi: 10.1093/hropen/hoac009
- Colette S, Lousse JC, Defrère S, et al. Absence of aromatase protein and mRNA expression in endometriosis. Hum Reprod. 2009;24(9):2133–2141. doi: 10.1093/humrep/dep199
补充文件
