The effectiveness of the application of modern diagnostic criteria of cervical pathology
- Authors: Kazakova A.V.1, Lineva O.I.1, Kiyashko I.S.1, Dufinets I.E.1, Chechko S.M.2, Mishina A.I.1
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Affiliations:
- Samara State Medical University
- N.A. Semashko Samara City Clinical Hospital No. 2
- Issue: Vol 71, No 3 (2022)
- Pages: 5-12
- Section: Original Research
- URL: https://journals.eco-vector.com/jowd/article/view/90850
- DOI: https://doi.org/10.17816/JOWD90850
- ID: 90850
Cite item
Abstract
BACKGROUND: Cervical cancer is one of the four most common cancers today and is the second most common cancer among women in developing countries. According to World Health Organization estimates, in 2018, the number of new cases in these countries was 570,000 (84% of all new cases globally). About 311,000 women died of cervical cancer in 2018, with more than 85% of these deaths occurring in low- and middle-income countries. The detection of the disease in its later stages has not significantly reduced since 2018 (32.6% of all cases).
AIM: The aim of this study was to compare the information contents of conventional and liquid cytology methods in women with verified human papillomavirus of high oncogenic risk.
MATERIALS AND METHODS: We retrospectively analyzed 50 outpatient records of women aged 23 to 65 years who underwent colposcopy (cervical biopsy) based on the results of cervical screening. To establish the diagnosis, all patients underwent examination of smears from the cervix and cervical canal using conventional (n = 25) and liquid (n = 25) cytology methods. A molecular genetic study was carried out to detect high-oncogenic human papillomavirus types (16, 18, 31, 33, 35, 45, 51, 56, 58) in scraping of the cervix by real-time polymerase chain reaction. Women in the both study groups also underwent colposcopy with histological examination of the cervical biopsy specimen. The analysis of the obtained data was carried out using methods of parametric and nonparametric statistics. Inclusion criteria included cytological examination, verified human papillomavirus of high oncogenic risk, and colposcopy. Exclusion criteria included pregnancy and acute infectious diseases.
RESULTS: According to the results of histological examination, the percentage of coincidence of cytological and histological diagnosis in the group of women who underwent conventional cytological examination was 48%. The total number of discrepancies in this group was 13 (52.0 ± 9.99%). The number of women infected with human papillomavirus in the both study groups was almost the same (18 in the conventional cytology group and 19 in the liquid cytology group). The most common types of human papillomavirus among the examined patients were the 16th type (9 women) and the 18th type (6 women).
CONCLUSIONS: To date, cytological research methods have not lost their relevance, the liquid cytology method being a reliable screening test with high specificity, which reduces the number of unsatisfactory preparations for analysis and false negative results. The most informative for women with type 2 or type 3 of transformation zone is the use of the liquid cytology method.
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About the authors
Anna V. Kazakova
Samara State Medical University
Email: amigo14021980@yandex.ru
ORCID iD: 0000-0002-9483-8909
SPIN-code: 5129-5915
MD, Dr. Sci. (Med.), Assistant Professor
Russian Federation, 89 Chapaevskaya St., Samara, 443099Olga I. Lineva
Samara State Medical University
Email: oilineva@yandex.ru
ORCID iD: 0000-0003-2232-0980
SPIN-code: 6805-2218
MD, Dr. Sci. (Med.), Professor
Russian Federation, 89 Chapaevskaya St., Samara, 443099Irina S. Kiyashko
Samara State Medical University
Email: kiyashkoi@yandex.ru
ORCID iD: 0000-0002-1936-2322
SPIN-code: 1596-1967
MD, Cand. Sci. (Med.)
Russian Federation, 89 Chapaevskaya St., Samara, 443099Irina E. Dufinets
Samara State Medical University
Email: dr.dufinets@yandex.ru
ORCID iD: 0000-0002-2281-6495
SPIN-code: 4683-6421
MD, Cand. Sci. (Med.)
Russian Federation, 89 Chapaevskaya St., Samara, 443099Svetlana M. Chechko
N.A. Semashko Samara City Clinical Hospital No. 2
Email: svetlana-chechko@mail.ru
ORCID iD: 0000-0002-3890-9944
MD
Russian Federation, 89 Chapaevskaya St., Samara, 443099Anna I. Mishina
Samara State Medical University
Author for correspondence.
Email: anna.mishina.94@mail.ru
ORCID iD: 0000-0002-0091-2785
MD
Russian Federation, 89 Chapaevskaya St., Samara, 443099References
- Ouh YT, Park JJ, Kang M, et al. Discrepancy between cytology and histology in cervical cancer screening: a multicenter retrospective Study (KGOG 1040). J Korean Med Sci. 2021;36(24):e164. doi: 10.3346/jkms.2021.36.e164
- Kaprin AD, Starinskiy VV, Petrova GV, editors. Zlokachestvennye novoobrazovaniya v Rossii v 2018 godu (zabolevaemost’ i smertnost’). Moscow: MNIOI im. P.A. Gertsena — filial FGBU “NMITS radiologiI” Minzdrava Rossii; 2019. (In Russ.)
- Arbyn M, Weiderpass E, Bruni L, et al. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. Lancet Glob Health. 2020;8(2):e191−e203. doi: 10.1016/S2214-109X(19)30482-6
- Mcharo R, Lennemann T, France J, et al. HPV type distribution in HIV positive and negative women with or without cervical dysplasia or cancer in East Africa. Front Oncol. 2021;11:763−717. doi: 10.3389/fonc.2021.763717
- Treco IC, Vieira VK, Silva JCD, et al. Prevalence and factors associated to cervical changes in units from the Single Health System. Revista gaúcha de enfermagem. 2021;42:e20200233. doi: 10.1590/1983-1447.2021.20200233. (In English, Portuguese).
- Cohen PA, Jhingran A, Oaknin A, Denny L. Cervical cancer. Lancet. 2019;393(10167):169−182. doi: 10.1016/S0140-6736(18)32470-X
- Tatarinova TA. The morbidity and mortality of cervix cancer in the Russian Federation in 2007−2018. Problems of Social Hygiene, Public Health and History of Medicine. 2021;29(4):892−897. (In Russ.). doi: 10.32687/0869-866X-2021-29-4-892-897
- Gupta R, Hariprasad R, Dhanasekaran K, et al. Reappraisal of cytology-histology correlation in cervical cytology based on the recent American Society of Cytopathology guidelines (2017) at a cancer research centre. Cytopathology. 2019;31(1):53−58. doi: 10.1111/cyt.12774
- You Y, Wang L, Li Y, et al. Multicenter randomized study of inosine pranobex versus acyclovir in the treatment of recurrent herpes labialis and recurrent herpes genitalis in Chinese patients. J. Dermatol. 2015; 42(6):596−601. doi: 10.1111/1346-8138.12845
- Kaprin AD, Starinskiy VV, Petrova GV, editors. Sostoyanie onkologicheskoy pomoshchi naseleniyu Rossii v 2018 godu. Moscow: MNIOI im. P.A. Gertsena — filial FGBU “NMITS radiologiI” Minzdrava Rossii; 2019. (In Russ.)
- Katsambas AD, Lotti TM, editors. European handbook of dermatological treatments. Berlin: Springer Verlag; 2003.
- Kisina VI, Vorob’ev PA. Protokoly vedeniya bol’nykh. Infektsii, peredavaemye polovym putem. Moscow: N’yudiamed; 2011. (In Russ.)
- Chissov VI, Starinskiy VV, Petrova GV, editors. Zlokachestvennye novoobrazovaniya v Rossii v 2010 godu (zabolevaemost’ i smertnost’). Moscow: MNIOI im. P.A. Gertsena — filial FGBU “NMITS radiologiI” Minzdrava Rossii; 2012. (In Russ.)