Markers of bone remodeling in patients with surgical menopause undergoing hormone replacement therapy with Divigel

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详细

Twenty women with surgical menopause, 40-50 years of age, received hormonal replacement therapy with transdermic preparation Divigel during 24 months. On the background of therapy with Divigel we witnessed normalization of indeces of osteal remodeling—considerable decrease pyridinoline and deoxypyridinoline, and elevation of alkaline phosphatase. Mineral density of bone tissue in the group of patients with surgical menopause waslowerin comparison with control (p<0,01). Divigeltumedto exertprotective influence on the bone tissue inpatients with osteoporosis irrespective о f duration о f surgical menopause by the beginning of therapy.

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作者简介

S. Yureneva

Scientific Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences; Russian Cancer Research Center. N.N.Blokhina RAMS

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Email: info@eco-vector.com
俄罗斯联邦, Moscow

V. Smetnik

Scientific Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences; Russian Cancer Research Center. N.N.Blokhina RAMS

Email: info@eco-vector.com
俄罗斯联邦, Moscow

N. Lyubimova

Scientific Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences; Russian Cancer Research Center. N.N.Blokhina RAMS

Email: info@eco-vector.com
俄罗斯联邦, Moscow

V. Abaev

Scientific Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences; Russian Cancer Research Center. N.N.Blokhina RAMS

Email: info@eco-vector.com
俄罗斯联邦, Moscow

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2. Fig. 1. Frequency of increase in markers of bone resorption in patients with surgical menopause during therapy with Divigel

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3. Fig. 2. Changes in BMD in patients with surgical menopause before

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4. Fig. 3. Dynamics of excretion of pyridinoline and deoxypyridinoline in patients with surgical menopause during therapy with Divigel

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5. Fig. 4. Dynamics of changes in BMD (D%) in the group of patients with surgical menopause during HRT with Divigel

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