The effectiveness of the drug Divigel in patients with surgical menopause

Twenty women with surgical menopause aged40-50years received parenteral hormonal replacement therapy with estradiol (preparation Divigel) for the period of 12 months. Twenty healthy women formed the control group. The following indeces were estimated during the study: menopausal Kupperman’s index, and the leveloffollicle-stimulatinghormone and estradiol in blood serum. Kupperman’s index remarkably decreased in the course of treatment (p<0,05). Decrease of FSH level was associated with stable growth of estradiol level (p<0,05). The absence of manifested side effects and considerable change of body build index, the possibility of choosingthe minimal effective doze individually allow to apply HRT with Divigel more widely.