RATIONAL CHOICE OF EYE DROPS FOR PUPIL DILATION IN NEONATES



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Abstract

Background. The problem of a choice of eye drops with the minimum side effects for mydriasis for screening of retinopathy of prematurity is actual.

The purpose – to estimate clinical efficiency of the combined mydriatic eye drops Fenicamide in ophthalmoneonatal practice.

Materials and methods. Under supervision were 75 (150 eyes) newborns and babies aged from 1 day to 3 months (on average 38,2±32,2 days). Patients are distributed on 3 groups depending on gestational age: the group 1 – 25 full-term children; group 2 – 25 premature children and group 3 – 25 very premature children. For achievement of the mydriasis once on 1 drop buried in the combined drug of 5% phenylephrine and 0,8% tropicamide. Observed dynamics of change of diameter of a pupil within 4 hours in each group of patients and fixed side effects within 24 hours. By means of the pediatric retinal camera RetCam 3 estimated quality of visualization of the fundus.

Results. The maximum dilation of a pupil (on average 6,5±0,5 mm) was reached on average to 60±14 minute after an instillation, remained within 1 hour and was normalized in 4 hours. Mydriasis varied from 5,9 mm at very premature children to 7 mm at the full-term newborns (p>0,05) and allowed to investigate in full and qualitatively of the fundus of all patients, including visualization of peripheral zones of the retina when screening ROP. It is established that side effects on the drug were absent at 76% (57) children, were present – at 24% (18) patients, mainly in the form of local reaction.

Conclusion. Eye drops Fenicamide is an effective mydriatic, with the convenient regimen of instillation, have the minimum side effects and can be recommended for wide use in ophthalmoneonatal practice.

About the authors

Elvira Irekovna Saidasheva

North-Western State Medical University named after I.I. Mechnikov; Childrenꞌs Hospital #1, Saint Petersburg

Email: esaidasheva@mail.ru
ORCID iD: 0000-0003-4012-7324
SPIN-code: 7800-3264

Dr. Sci. Med., professor of the department of ophthalmology North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg

Russian Federation, 191015, St. Petersburg, ul. Kirochnaya, 41; 198205, St. Petersburg, ul. Avant-garde, d. 14, lit. A

Svetlana Vladimirovna Biyanovskaya

North-Western State Medical University named after I.I. Mechnikov; Childrenꞌs Hospital #1, Saint Petersburg

Author for correspondence.
Email: solncemia@mail.ru
ORCID iD: 0000-0001-7503-2611
SPIN-code: 6981-9826
ResearcherId: P-6836-2014
http://www.researcherid.com/rid/P-6836-2014

assistant of the Department of Ophthalmology North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg

ophthalmologist, department of neonatal, Childrenꞌs Hospital №1, Saint-Petersburg

Russian Federation, 191015, St. Petersburg, ul. Kirochnaya, 41; 198205, St. Petersburg, ul. Avant-garde, d. 14, lit. A    

Fedor Vladislavovich Kovshov

North-Western State Medical University named after I.I. Mechnikov; Childrenꞌs Hospital #1, Saint Petersburg

Email: fedor_vk@mail.ru
ORCID iD: 0000-0001-6039-1398

assistant of the Department of Ophthalmology North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg;

ophthalmologist, department of neonatal, Childrenꞌs Hospital №1

Russian Federation, 191015, St. Petersburg, ul. Kirochnaya, 41; 198205, St. Petersburg, ul. Avant-garde, d. 14, lit. A

Marina Sergeevna Petrachkova

North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg

Email: mpetrachkova@mail.ru
ORCID iD: 0000-0001-8227-4897
SPIN-code: 2961-2679

postgraduate of the department of ophthalmology North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg

Russian Federation, 191015, St. Petersburg, ul. Kirochnaya, 41;

Olga Sergeevna Dolgova

North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg

Email: alaknar@yandex.ru
ORCID iD: 0000-0003-3473-163X

postgraduate of the department of ophthalmology North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg

Russian Federation, 191015, St. Petersburg, ul. Kirochnaya, 41

Yuri Viktorovich Levadnev

North-Western State Medical University named after I.I. Mechnikov; Childrenꞌs Hospital #1, Saint Petersburg

Email: yu-lev@yandex.ru
ORCID iD: 0000-0003-4087-9462
SPIN-code: 5639-6315

anesthesiologist-reanimathologist, Childrenꞌs Hospital №1, Saint-Petersburg

Russian Federation, 191015, St. Petersburg, ul. Kirochnaya, 41; 198205, St. Petersburg, ul. Avant-garde, d. 14, lit. A

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Copyright (c) Saidasheva E.I., Biyanovskaya S.V., Kovshov F.V., Petrachkova M.S., Dolgova O.S., Levadnev Y.V.

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