Representativity of macular edema mapping using en face optical coherence tomography, retinal thickness map, and fluorescein angiography

Cover Page
Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract


Aim. To study the representativity of macular edema mapping using en face optical coherence tomography (OCT), retinal thickness map, and fluorescein angiography (FA).

Methods. In this retrospective cross-sectional study, 8 patients (15 eyes) with diabetic macular edema (2 females and 6 males, mean age 66.5 ± 8.1 years) were included. All patients OCT (retinal thickness map and en face OCT) and FA were performed. En face slab was constructed between inner plexiform layer and retinal pigment epithelium. The area of macular edema was measured by two masked graders independently.

Results. There was no statistically significant difference in the area of macular edema between FA, en face OCT, and retinal thickness maps, 12.7 ± 8.1, 14.5 ± 8.4, 10.4 ± 6.9 mm2, respectively (ANOVA × 3, p = 0.34). Intraclass correlation coefficient for three methods was 0.87 and 0.95, for individual and mean values, respectively.

Conclusion. En face OCT is an adequate non-invasive alternative for FA in evaluating the area of macular edema and planning of grid macular laser photocoagulation.


Full Text

Restricted Access

About the authors

Dmitrii S. Maltsev

S.M. Kirov Military Medical Academy

Author for correspondence.
Email: glaz.med@yandex.ru
ORCID iD: 0000-0001-6598-3982

Russian Federation, Saint Petersburg

MD, PhD, Head of Medical Retina Division of Ophthalmology Department

Alexey N. Kulikov

S.M. Kirov Military Medical Academy

Email: alexey.kulikov@mail.ru

Russian Federation, Saint Petersburg

MD, DSc, head of ophthalmology department

Alina A. Kazak

S.M. Kirov Military Medical Academy

Email: ali-kazak@mail.ru

Russian Federation, Saint Petersburg

Medical student

Alexander S. Vasiliev

S.M. Kirov Military Medical Academy

Email: shizolamp@gmail.com

Russian Federation, Saint Petersburg

MD, Ophthalmologist of the Ophthalmology Department

References

  1. Norton EW, Gutman F. Diabetic retinopathy studied by fluorescein angiography. Trans Am Ophthalmol Soc. 1965;63:108-128.
  2. Cooney MJ, Schachat AP. Screening for diabetic retinopathy. Int Ophthalmol Clin. 1998;38(2):111-212. https://doi.org/10.1097/00004397-199803820-00009.
  3. Keane PA, Sadda SR. Retinal imaging in the twenty-first century: state of the art and future directions. Ophthalmology. 2014;121(12): 2489-2500. https://doi.org/10.1016/j.ophtha.2014.07.054.
  4. Hee MR, Puliafito CA, Wong C, et al. Quantitative assessment of macular edema with optical coherence tomography. Arch Ophthalmol. 1995;113(8):1019-1029. https://doi.org/10.1001/archopht.1995.01100080071031.
  5. Gass JD. A fluorescein angiographic study of macular dysfunction secondary to retinal vascular disease. IV. Diabetic retinal angiopathy. Arch Ophthalmol. 1968;80(5):583-591. https://doi.org/10.1001/archopht.1968.00980050585004.
  6. Leitgeb RA. En face optical coherence tomography: a technology review. Biomed Opt Express. 2019;10(5):2177-2201. https://doi.org/10.1364/BOE.10.002177.
  7. Бойко Э.В., Мальцев Д.С. Фокальная навигационная лазерная коагуляция сетчатки с помощью ОКТ-картирования // Вестник офтальмологии. – 2016. – T. 132. – № 3. – С. 56–60. [Boyko EV, Mal’tsev DS. En face’ optical coherence tomography guided focal navigated laser photocoagulation. Annals of ophthalmology. 2016;132(3):56-60. (In Russ.)]. https://doi.org/10.17116/oftalma2016132356-60.
  8. Boiko EV, Maltsev DS. Retro-mode scanning laser ophthalmoscopy planning for navigated macular laser photocoagulation in macular edema. J Ophthalmol. 2016;2016:3726353. https://doi.org/10.1155/2016/3726353.
  9. Hasegawa N, Nozaki M, Takase N, et al. New insights into microaneurysms in the deep capillary plexus detected by optical coherence tomography angiography in diabetic macular edema. Invest Ophthalmol Vis Sci. 2016;57(9):348-355. https://doi.org/10.1167/iovs.15-18782.
  10. Maltsev DS, Kulikov AN, Burnasheva MA, et al. Structural en face optical coherence tomography imaging for identification of leaky microaneurysms in diabetic macular edema. Int Ophthalmol. 2020;40(4):787-794. https://doi.org/10.1007/s10792-019-01239-w.

Supplementary files

Supplementary Files Action
1.
Fig. 1. Dot-plot showing differences in the area of macular edema between fluorescein angiography images, en face optical coherence tomography images, and retinal thickness maps

Download (31KB) Indexing metadata
2.
Fig. 2. Visualization of macular edema area using fluorescein angiography, en face optical coherence tomography, and retinal thickness mapping in eyes with focal fovea-involving macular edema (а–с): a – according to the masked grader’s estimation, based on fluorescein angiography (FA), the area of macular edema was 7.5 mm2, b – based on en face optical coherence tomography (OCT) the area of macular edema was 6.4 mm2, c – based on retinal thickness map the area of macular edema was 4.8 mm2; and fovea-sparing (d–f) flat macular edema: d – based on fluorescein angiography (FA) the area of macular edema was 1.5 mm2; e – based on en face optical coherence tomography (OCT) the area of macular edema was 2.4 mm2; f – based on retinal thickness map a masked grader failed to delineate the area of macular edema

Download (628KB) Indexing metadata
3.
Fig. 3. Bland – Altman plot showing differences in macular edema area measured based on fluorescein angiography and en face optical coherence tomography images

Download (41KB) Indexing metadata
4.
Fig. 4. Bland – Altman plot showing differences in macular edema area measured based on fluorescein angiography images and retinal thickness maps

Download (40KB) Indexing metadata

Statistics

Views

Abstract - 78

PDF (Russian) - 6

Cited-By


Article Metrics

Metrics Loading ...

PlumX

Dimensions


Copyright (c) 2020 Maltsev D.S., Kulikov A.N., Kazak A.A., Vasiliev A.S.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies