The influence of some general diseases for changes on the ocular surface after trabeculectomy

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Abstract

BACKGROUND: By now, possible effects of diabetes mellitus and arterial hypertension on the ocular surface changes after trabeculectomy have not been evaluated.

AIM: Analysis of the effects of arterial hypertension therapy and diabetes mellitus on the ocular surface changes after trabeculectomy.

MATERIALS AND METHODS: The study group consisted of 443 patients, including those with arterial hypertension (179 patients), non insulin dependent compensated type 2 diabetes mellitus (25 patients) and their combination (53 persons), operated in 2016–2020 in the City Multifield Hospital No. 2, Saint-Petersburg, for primary open-angle noncompensated glaucoma and then observed for 6 to 24 months. The dynamics of ocular surface disease index (OSDI), tear film break-up time (TBUT), and amount of total tear production has been studied.

RESULTS: The probability of the trabeculectomy success did not depend on the concomitant comorbidity. In contrast to intraocular pressure, the criteria for subjective and objective assessment of the ocular surface state were not subject to such obvious changes. In diabetic patients, the studied criteria have not changed compared to the baseline.

CONCLUSIONS: The mentioned systemic diseases do not influence the state of the ocular surface in patients with glaucoma, and are not an independent risk factor for the failure of the IOP-lowering surgical procedure. The presence of diabetes mellitus prevents the accompanying a successful trabeculectomy regression of symptoms and clinical and functional signs of dry eye disease.

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About the authors

Аnastasiia V. Аntonova

Saint Petersburg Multifield Hospital No. 2; Saint Petersburg State University

Author for correspondence.
Email: dr.antonova.av@gmail.com
ORCID iD: 0000-0002-2639-2765
SPIN-code: 2166-3936

Ophthalmologist

Russian Federation, 5 Uchebnyi lane, Saint Petersburg, 194354; 7–9 Universitetskaya embankment, Saint Petersburg, 199034

Vadim P. Nikolaenko

Saint Petersburg Multifield Hospital No. 2; Saint Petersburg State University

Email: dr.Nikolaenko@mail.ru
ORCID iD: 0000-0002-6393-1289
SPIN-code: 4906-2542

MD, PhD, Doc. Sci. (Med.), Head of Ophthalmology Department, professor Otorhinolaryngology and ophthalmologydepartment

Russian Federation, 5 Uchebnyi lane, Saint Petersburg, 194354; 7–9 Universitetskaya embankment, Saint Petersburg, 199034

Vladimir V. Brzheskiy

Saint Petersburg State Pediatric Medical University

Email: vvbrzh@yandex.ru
ORCID iD: 0000-0001-7361-0270
SPIN-code: 5442-0989

MD, Dr. Sci. (Med.), Professor

Russian Federation, Saint Petersburg

Alexandr Ja. Vuks

V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology

Email: ayavuks@bekhterev.ru
ORCID iD: 0000-0002-6700-0609
SPIN-code: 2290-4021
Russian Federation, Saint Petersburg

Sergey A. Koskin

Kirov Military Medical Academy; Pavlov Institute of Physiology of the Russian Academy of Sciences

Email: eyemillenium@mail.ru
ORCID iD: 0000-0003-3994-9232
SPIN-code: 9882-6880

Dr. Sci. (Medicine), Professor

Russian Federation, Saint Petersburg; Saint Petersburg

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2. Table 1. Supplement 1 Descriptive statistics and comparison of formed groups
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3. Table 2. Supplement Differences between initial data of men and women with concomitant arterial hypertension, diabetes mellitus, their combination, and without these conditions, Mann–Whitney U-test
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