Recurrent corneal erosion
- Authors: Trufanov S.V.1, Seyfeddin A.S.1, Turgel V.A.1
-
Affiliations:
- Pavlov First St. Petersburg State Medical University
- Issue: Vol 14, No 4 (2021)
- Pages: 55-64
- Section: Reviews
- URL: https://journals.eco-vector.com/ov/article/view/90921
- DOI: https://doi.org/10.17816/OV90921
- ID: 90921
Cite item
Abstract
Recurrent corneal erosion (RCE) is a common recurrent disease caused by abnormal adhesion of the corneal epithelium to the basement membrane. Previous corneal trauma is the most common cause of this disease. Corneal dystrophies, such as dystrophy of the epithelial basement membrane, Meesmann dystrophy, Reis–Bücklers dystrophy, lattice dystrophy and granular dystrophies, are also involved in the pathogenesis of recurrent corneal erosion. The main diagnostic methods for recurrent corneal erosion are slit-lamp examination and taking of medical history. Detectable RCE changes range from small corneal irregularities (such as epithelial microcysts) to large areas of loose epithelium or epithelial defects detecting by fluorescein staining. Areas of irregular epithelium with grayish inclusions or microcysts and a “fingerprint” pattern or a map-like defects are also revealed. The main goal of treatment is to relieve pain, stimulate re-epithelialization, and fully restore the adhesion of the basement membrane and epithelium. Lubricants and matrix proteinase inhibitors are prescribed as first-line therapy, and blood derivatives can be used as second-line therapy. When conservative therapy fails, surgical procedures are used (excimer laser phototherapeutic keratectomy, Bowman’s membrane polishing with diamond drill, anterior stromal puncture, corneal collagen cross-linking).
Full Text
About the authors
Sergey V. Trufanov
Pavlov First St. Petersburg State Medical University
Email: trufanov05@mail.ru
ORCID iD: 0000-0003-4360-793X
Dr. Sci. (Med.), Professor
Russian Federation, 6–8, L'va Tolstogo st., Saint Petersburg, 197022Akhmed S. Seyfeddin
Pavlov First St. Petersburg State Medical University
Author for correspondence.
Email: dr.aseifeddine@gmail.com
ORCID iD: 0000-0003-1789-4269
Postgraduate student
Russian Federation, 6–8, L'va Tolstogo st., Saint Petersburg, 197022Vadim A. Turgel
Pavlov First St. Petersburg State Medical University
Email: zanoza194@gmail.com
ORCID iD: 0000-0003-3049-1974
Postgraduate student
Russian Federation, 6–8, L'va Tolstogo st., Saint Petersburg, 197022References
- Suri K, Kosker M, Duman F, et al. Demographic patterns and treatment outcomes of patients with recurrent corneal erosions related to trauma and epithelial and Bowman layer disorders. Am J Ophthalmol. 2013;156(6):1082–1087. doi: 10.1016/j.ajo.2013.07.022
- Ramamurthi S, Rahman MQ, Dutton GN, Ramaesh K. Pathogenesis, clinical features and management of recurrent corneal erosions. Eye. 2006;20(6):635–644. doi: 10.1038/sj.eye.6702005
- Hykin PG, Foss AE, Pavesio C, Dart JK. The natural history and management of recurrent corneal erosion: a prospective randomised trial. Eye. 1994;8:35–40. doi: 10.1038/eye.1994.6
- Hansen E. Om den intermitterende keratitis vesicularis neuralgica af traumatisk opindelse. Hospitalis-Tidende. 1872;51:201–203.
- Pronkin IA, Maychuk DY. Recurrent corneal erosion: ethology, pathogenesis, diagnosis and treatment. Fyodorov Journal of Ophthalmic Surgery. 2015;(1):62–67. (In Russ.)
- Miller DD, Hasan SA, Simmons NL, Stewart MV. Recurrent corneal erosion: a comprehensive review. Clinical ophthalmology. 2019;13:325–335. doi: 10.2147/OPTH.S157430
- Chandler PA. Recurrent corneal erosion of the cornea. Trans Am Ophthalmol Soc. 1945;28(4):355363. doi: 10.1016/0002-9394(45)90937-8
- De Voe A. Certain abnormalities in Bowman’s membrane with particular reference to fingerprint lines in the cornea. Trans Am Ophthalmol Soc. 1962;60:195–201.
- Cogan DG, Donaldson DD, Kuwabara T, et al. Microcystic dystrophy of the corneal epithelium. Trans Am Ophthalmol Soc. 1964;63:213.
- Guerry D. Fingerprint lies in the cornea. Am J Ophthalmol. 1950;33:724–726.
- Laibson PR. Recurrent corneal erosions and epithelial basement membrane dystrophy. Eye & Contact Lens. 2010;36(5):315–317. doi: 10.1097/ICL.0b013e3181f18ff7
- Thakrar R, Hemmati HD. Treatment of recurrent corneal erosions. Eyenet Magazine. 2013;3:39–41.
- Lowe RF. Recurrent erosion of the cornea. Br J Ophthalmol. 1970;54(12):805–809. doi: 10.1136/bjo.54.12.805
- Tripathi RC., Bron AJ. Ultrastructural study of non-traumatic recurrent corneal erosion. Br J Ophthalmol. 1972;56(2):73–85. doi: 10.1136/bjo.56.2.73
- Meek KM, Boote C. The organization of collagen in the corneal stroma. Exp Eye Res. 2004;78(3):503–512. doi: 10.1016/j.exer.2003.07.003
- Sridhar MS. Anatomy of cornea and ocular surface. Indian J Ophthalmol. 2018;66(2):190–194. doi: 10.4103/ijo.ijo_646_17
- Lin SR, Aldave AJ, Chodosh J. Recurrent corneal erosion syndrome. Br J Ophthalmol. 2019;103(9):1204–1208. doi: 10.1136/bjophthalmol-2019-313835
- Brown N, Bron A. Recurrent erosion of the cornea. Br J Ophthalmol. 1976;60(2):84–96. doi: 10.1136/bjo.60.2.84
- Trufanov SV, Malozhen SA, Polunina EG, et al. Recurrent corneal erosion syndrome (a review). Ophthalmology in Russia. 2015;12(2): 4–12. (In Russ.) doi: 10.18008/1816-5095-2015-2-4-12
- Weiss JS, Møller HU, Aldave AJ, et al. IC3D classification of corneal Dystrophies – Edition 2. Cornea. 2015;34(2):117–159. doi: 10.1097/ICO.0000000000000307
- Findley FM. Recurrent corneal erosions. J Am Optom Assoc. 1986;57:392–396.
- Dohlman CN. Healing problems in the corneal epithelium. Jpn J Ophthalmol. 1981;25:131–134.
- Buck RC. Hemidesmosomes of normal and regenerating mouse corneal epithelium. Virchows Arch B Cell Pathol Incl Mol Pathol. 1982;41(1–2):1–16. doi: 10.1007/BF02890267
- Goldman JN, Dohlman CH, Kravitt BA. The basement membrane of the human cornea in recurrent epithelial erosion syndrome. Trans Am Acad Ophthalmol Otolaryngol. 1969;73:471–481.
- Aitken DA, Beirouty ZA, Lee WR. Ultrastructural study of the corneal epithelium in the recurrent erosion syndrome. Br J Ophthalmol. 1995;79(3):282–289. doi: 10.1136/bjo.79.3.282
- Rosenberg ME, Tervo TM, Petroll WM, Vesaluoma MH. In vivo confocal microscopy of patients with corneal recurrent erosion syndrome or epithelial basement membrane dystrophy. Ophthalmology. 2000;107(3):565–573. doi: 10.1016/S0161-6420(99)00086-X
- Trufanov SV, Tekeeva LYu, Surnina ZV, Malozhen SA. Morphological changes in the cornea of patients with recurrent corneal erosion after diamond burr polishing of bowman’s membrane. The Russian annals of ophthalmology. 2019;135(5):24–30. (In Russ.) doi: 10.17116/oftalma201913505124
- Martin R. Cornea and anterior eye assessment with slit lamp biomicroscopy, specular microscopy, confocal microscopy, and ultrasound biomicroscopy. Indian J Ophthalmol. 2018;66(2):195–201. doi: 10.4103/ijo.IJO_649_17
- Das S, Seitz B. Recurrent corneal erosion syndrome. Surv Ophthalmol. 2008;53(1):3–15. doi: 10.1016/j.survophthal.2007.10.011
- Ziakas NG, Boboridis KG, Terzidou C, et al. Long-term follow up of autologous serum treatment for recurrent corneal erosions. Clin Exp Ophthalmol. 2010;38(7):683–687. doi: 10.1111/j.1442-9071.2010.02304.x
- Napoli PE, Braghiroli M, Iovino C, et al. A study of refractory cases of persistent epithelial defects associated with dry eye syndrome and recurrent corneal erosions successfully treated with cyclosporine A 0.05 % eye drops. Drug Des Devel Ther. 2019;13:2001–2008. doi: 10.2147/DDDT.S207453
- Sobrin L, Liu Z, Monroy DC, et al. Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant. Invest Ophthalmol Vis Sci. 2000;4:1–7.
- Hope-Ross MW, Chell PB, Kervick GN, et al. Oral tetracycline in the treatment of recurrent corneal erosions. Eye. 1994;8:384–388. doi: 10.1038/eye.1994.91
- Dursun D, Kim M, Solomon A, Pflugfelder S. Treatment of Recalcitrant Recurrent Corneal Erosions with Inhibitors of Matrix Metalloproteinase-9, Doxycycline and Corticosteroids. Am J Ophthalmol. 2001;132(1):8–13. doi: 10.1016/s0002-9394(01)00913-8
- Solomon A, Rosenblatt M, Li DQ, et al. Doxycycline inhibition of interleukin-1 in the corneal epithelium. Invest Ophthalmol Vis Sci. 2000;41(5):25442557. doi: 10.1016/S0002-9394(00)00755-8
- Yoon KC. Use of umbilical cord serum in ophthalmology. Chonnam medical journal. 2014;50(3):82–85. doi: 10.4068/cmj.2014.50.3.82
- Benitez-Del-Castillo JM, Rodríguez-Bayo S, Fontan-Rivas E, et al. Treatment of recurrent corneal erosion with substance P-derived peptide and insulin-like growth factor I. Arch Ophthalmol. 2005;123(10):1445–1447. doi: 10.1001/archopht.123.10.1445
- Fraunfelder FW, Cabezas M. Treatment of recurrent corneal erosion by extended-wear bandage contact lens. Cornea. 2011;30(2):164–166. doi: 10.1097/ICO.0b013e3181e84689
- McLean EN, MacRae SM, Rich LF. Recurrent erosion. Treatment by anterior stromal puncture. Ophthalmology. 1986;93:784–788
- Zauberman N, Artornsombudh P, Elbaz U, et al. Anterior Stromal Puncture for the Treatment of Recurrent Corneal Erosion Syndrome: Patient Clinical Features and Outcomes. Am J Ophthalmol. 2014;157(2):273–279. doi: 10.1016/j.ajo.2013.10.005
- Maréchal-Courtois C, Duchesne B. Recurrent corneal erosion. Bull Soc Belge Ophtalmol. 1993;247(1):13–15.
- Katz HR, Snyder ME, Green WR, et al. Nd: YAG laser photo-induced adhesion of the corneal epithelium. Am J Ophthalmol. 1994;118(5):612–622. doi: 10.1016/S0002-9394(14)76576-6
- Buxton JN, Constad WH. Superficial epithelial keratectomy in the treatment of epithelial basement membrane dystrophy. Ann Ophthalmol. 1987;19(3):92–96.
- Buxton JN, Fox ML. Superficial epithelial keratectomy in the treatment of epithelial basement membrane dystrophy. Arch Ophthalmol. 1983;101(3):392–395. doi: 10.1001/archopht.1983.01040010392008
- Gipson I.K. Adhesive mechanisms of the corneal epithelium. Acta Ophthalmol. Suppl. 1992;(202):13–17. doi: 10.1111/j.1755-3768.1992.tb02162.x
- O’Brart DP, Muir MG, Marshall J. Phototherapeutic keratectomy for recurrent corneal erosions. Eye. 1994;8:378–83. doi: 10.1038/eye.1994.90
- Jaun S, Austin DJ. Phototherapeutic keratectomy for the treatment of recurrent corneal erosions. Cataract Refract Surg. 1999;25(12):1610–1614. doi: 10.1136/bjo.86.3.270
- Elmoddather M. Phototherapeutic keratectomy versus corneal cross linking for treatment of recurrent corneal erosion. AAMJ. 2013;11(3):261–268.
- Maini R, Loughnan MS. Phototherapeutic keratectomy re-treatment for recurrent corneal erosion syndrome. Br J Ophthalmol. 2002;86(3):270–272. doi: 10.1136/bjo.86.3.270
- Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-α-induced collagen crosslinking for the treatment of keratoconus. Cornea. 2003;135(5):620–627. doi: 10.1016/S0002-9394(02)02220-1
- Tabibian D, Richoz O, Hafezi F. PACK-CXL: Corneal Cross-linking for Treatment of Infectious Keratitis. J Ophthalmic Vis Res. 2015;10(1):77–80. doi: 10.4103/2008-322X.156122
- Wollensak G, Aurich H, Wirbelauer C, Pham DT. Potential use of riboflavin/UVA cross-linking in bullous keratopathy. Ophthalmic Res. 2009;41(2):114–117. doi: 10.1159/000187630
- Novikov SA, Tkachenko NV, Frolov OA, Seyfeddin AS. Long-term results of corneal collagen crosslinking for recurrent corneal erosion. Ophthalmology Journal. 2021;14(1):15–24. (In Russ.) doi: 10.17816/OV61269