A comparative evaluation of antimicrobial eye drops cytotoxicity

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Abstract

In addition to the spectrum of antibacterial activity of antimicrobial medicines and their pharmacokinetic and pharmacodynamic properties, their safety is also an important issue. Currently, there is no consensus on the fluoroquinolone toxicity. The purpose of this study was to compare in vitro the overall cytotoxic effect of six antibacterial fluoroquinolone eye drops: 1. Cipromed™ (ciprofloxacin 0.3 %; Sentiss Pharma Pvt. Ltd., India); 2. Floxal™ (ofloxacin 0.3 %; Dr. Gerhard Mann, Chem.-Pharm. Fabrik GmbH, Germany); 3. Oftaquix™ (levofloxacin 0.5 %; Santen Oy, Finland); 4. Signicef® (levofloxacin 0.5 %; Sentiss Pharma Pvt. Ltd., India); 5. Vigamox® (moxifloxacin 0.5 %; Alcon Laboratories, Inc., USA); 6. Zymar® (gatifloxacin 0.3 %; Allergan Sales LLC, USA). The study showed the possibility of using cultured cells for comparative evaluation of cytotoxic effects of various ophthalmic preparations. We found that tested antimicrobial medicines may have a cytostatic effect in vitro and differ in their cytotoxic potential.

About the authors

Olga Igorevna Aleksandrova

Institute of Cytology of the Russian Academy of Science

Email: elga.aleks@gmail.com
junior research scientist, Department of cell cultures, Laboratory of cell biology in culture, Group of cell biotechnology

Igor Nikolaevich Okolov

St. Petersburg branch of IR & TC «Eye Microsurgery» named after academician S. N. Fyodorov

MD, PhD, Head of the Clinical Bacteriological Laboratory

Yuri Victorovich Takhtaev

St. Petersburg branch of IR & TC «Eye Microsurgery» named after academician S. N. Fyodorov

Vice-director

Juliya Igorevna Khorolskaya

Institute of Cytology of the Russian Academy of Science

laboratory assistant-scientist, Department of cell cultures, Laboratory of cell biology in culture, Group of cell biotechnology. Institute of Cytology

Tamara Slavikovna Hintuba

North-Western State Medical University named after I. I. Mechnikov

MD, ophthalmologist, research student, Dep. of Ophthalmology

Miralda Ivanovna Blinova

Institute of Cytology of the Russian Academy of Science

PhD, leading research scientist, Department of cell cultures, Laboratory of cell biology in culture, Group of cell biotechnology. Institute of Cytology

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Copyright (c) 2015 Aleksandrova O.I., Okolov I.N., Takhtaev Y.V., Khorolskaya J.I., Hintuba T.S., Blinova M.I.

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