Vol 8, No 1 (2015)

Articles
Optical coherence tomography can be used in evaluation of morphological and functional results after successful rhegmatogenous retinal detachment surgery with different tamponade agents
Avanesova T.A.
Abstract
Background: Optical coherence tomography (OCT) findings are helpful in assessing the cause of reduced visual acuity (VA) after successful rhegmatogenous retinal detachment (RRD) surgery. Objective: To study anatomical and functional results after successful RRD surgery with gas-air mixture or silicone oil (SO) tamponade using OCT. Materials and methods. 70 patients were divided into 2 groups: group I (n = 34) - gas-air mixture tamponade; group II (n = 36) - SO tamponade. At baseline, were no significant differences by gender, age and VA between the groups. Follow-up was 12 months after the surgery. OCT was performed with the Cirrus HD-OCT 4000, CARL ZEISS MEDITEC, USA. Results: VA increased significantly in both groups. Regression analysis showed lower VA in group II and statistically significant association between VA and IS/OS and ELM defects. Сonclusions. There is a strong association of disruption of the IS/OS and ELM with reduced vision after successful retinal detachment surgery. Gas-air mixture tamponade showed some benefits in comparison with SO tamponade.
Ophthalmology journal. 2015;8(1):5-11
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Errors in supplementary toric IOL implantation (Sulcoflex toric, Rayner)
Khripun K.V., Rakhmanov V.V., Ramazanova A.M.
Abstract
In the article, the results of a combined surgical treatment method of induced astigmatism in a pseudophakic eye are presented. The authors describe an initial case of “wrong” supplementary toric IOL Sulcoflex (Rayner, Great Britain) position and its influence on aberrometric parameters.
Ophthalmology journal. 2015;8(1):12-17
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The analysis of the cataract surgery results in patients previously operated for retinal detachment
Shchukin A.D.
Abstract
The study purpose: to investigate the development of cataracts and their surgical treatment results in patients previously operated for retinal detachment. Material and methods: 53 patients, who for had cataract surgery after previous surgery for retinal detachment with retinal reattachment were included in the study. The mean age of patients was 62 years. Results and discussion: the cataract progression is characteristic for patients in whom vitrectomy was used in retinal detachment treatment. The cataract development after extrascleral procedures occurs more rarely. Cataract surgical treatment results are worse after the use of endovitreal retinal detachment treatment methods.
Ophthalmology journal. 2015;8(1):18-21
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The level of local cytokine production at different times after experimental ciliary body cryodestruction
Steblyuk A.N., Kolesnikova N.V., Gyunter V.E., Bodnya V.N., Tserkovnaya A.A.
Abstract
We assessed the level of pro- (IL1β, FNOα, IL2) and anti-inflammatory (IL10) cytokines in the anterior chamber fluid of experimental animals on the 3rd, 7th and 30th day, after an experimental ciliary body destruсtion with porous titanium nickelid cryoapplicator. Consistent changes of the cytokine content at the local level are reflecting the reactivity of the experimental animals as an answer both to surgery in ciliary body area, and to its experimental cyclodestruction using the cryoapplicator from titanium nickelid. The predominance of pro-inflammatory cytokines’ potential was found during the early period (3-7 day), and the balance normalization of pro- and anti-inflammatory cytokines was found at late observation period (30 days) due to the increase of the anti-inflammatory IL-10 production; this effect was maintained at the end of the long-term study period (1.5 years).
Ophthalmology journal. 2015;8(1):22-27
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Lugansk State Medical University, Lugansk, Ukraina
Petrunya A.M., Mukhamed A.K.
Abstract
The results of clinical studies indicate that the inclusion of thiol preparations in the complex treatment of patients with keratoconjunctivitis significantly reduces the severity of keratoconjunctivitis clinical symptoms, and allows reversing the disease process in the cornea within a shorter time.
Ophthalmology journal. 2015;8(1):28-35
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Prognosing intraocular pressure compensation in primary open-angle glaucoma patients at medical and surgical treatment
Soljannikova O.V., Berdnikova E.V., Ekgardt V.F., Dmitrienko V.N.
Abstract
Objective. Criteria specification and prognosis establishment of intraocular pressure compensation in primary open-angle glaucoma (POAG) patients at medical and surgical treatment based on integrated clinical and instrumental examination. Methods. 128 POAG subjects (234 eyes) receiving medical treatment were included in the study, surgery was performed in 42 patients (52 eyes). Results. The use of multiple clinical parameters into the statistical analysis leads to an increase in the probability of IOP compensation and correct prognosis (up to 84.0-98.4 % of cases) in medical treatment, and does not alter the prognosis accuracy at surgical treatment. In analysis of lower variables number, correct prognosis of IOP compensation at medical treatment can be established in 75.4-75.7 % of cases, and at surgical treatment - in 100 % of cases. The results of present study are the basis for a computer program development that could allow a practicing ophthalmologist to determine the prognosis of IOP compensation in a POAG-patient.
Ophthalmology journal. 2015;8(1):36-42
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Multicenter study of intraocular pressure level in patients with moderate and advanced primary open-angle glaucoma on treatment
Abysheva L.D., Avdeev R.V., Alexandrov A.S., Basinsky A.S., Blyum E.A., Brezhnev A.Y., Gazizova I.R., Galimova A.B., Gaponko O.V., Garkavenko V.V., Getmanova A.M., Gorodnichy V.V., Gorshkova M.S., Gusarevitch A.A., Dorofeev D.A., Zhavoronkov S.A., Zavadsky P.C., Zakhidov A.B., Zvereva O.G., Karimov U.R., Kulik A.V., Kuroyedov A.V., Lanin S.N., Lovpache D.N., Loskutov I.A., Molchanova E.V., Nefedov N.A., Ogorodnikova V.Y., Onufrichuk O.N., Openkova E.Y., Petrov S.Y., Rozhko Y.I., Sidenko T.A., Tashtitova L.B., Fomin N.E., Khudzhatova M.S.
Abstract
Introduction. For the past several decades, there has been a discussion as to whether elevated intraocular pressure is just ocular hypertension in a healthy eye, or a sign of glaucoma. Objective. To study the IOP values in patients with primary open-angle glaucoma at the beginning of the study and to correlated them with the disease progression and to determine optimal IOP levels. Material and methods. The final protocol included data from 812 right eyes of 637 glaucoma patients and 175 healthy subjects; the latter formed the control group. The mean age of examined patients was 71.8 ± 0.28 years; 72.00 (66.00; 77.00). Mean disease duration in glaucoma patients was 5.41 ± 0.17 years. The following parameters were assessed: visual acuity, clinical refraction, IOP level by Maklakov tonometry, central corneal thickness and IOP-lowering medication use. Results. In the age group - between 60 and 69 y.o., the IOP level in patients with advanced glaucoma was significantly higher than in patients with moderate glaucoma and healthy subjects. There was no significant difference in central corneal thickness either between glaucoma patients and healthy subjects (both male and female) or between glaucoma patients with different glaucoma changes. The IOP level was higher in patients treated with non-fixed combination of beta-blockers (BB) and prostaglandins (PG) regardless of the disease stage. According to the common standards the IOP level was found to be controlled in 69.93 % of patients with moderate glaucoma and 14.42 % of patients with advanced glaucoma. Conclusion. The results of the study could be used as clinical guidelines for determination of the optimal IOP range, choosing the optimal IOP-lowering medication(s) for starting therapy and during the follow-up in patients with moderate and advanced glaucoma stages.
Ophthalmology journal. 2015;8(1):43-60
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Congenital microphtalmos with cyst
Gorbachev D.S., Korovenkov R.I.
Abstract
The literature review related to congenital microphthalmus with cyst is presented. It sets out the views of the authors on etiology, pathogenesis, and clinical manifestations of this disease. Questions of embryogenesis, development and dynamics of the histological pattern in the course of cyst formation are considered.
Ophthalmology journal. 2015;8(1):61-68
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Biomechanical studies of the iris and the trabecular meshwork
Petrov S.Y., Podgornaya N.N., Aslamazova A.E., Safonova D.M.
Abstract
The article presents a literature review of the latest research in the field of ocular biomechanics with an accent on the role of biomechanical properties of anatomical structures in the development of ocular pathologies. Close attention is paid to biomechanical properties of the iris, the study of its structure and functioning in representatives of different races, as well as its role in anterior eye chamber angle closure and the pathogenesis of angle-closure glaucoma. Experimental and clinical researches of trabecular meshwork biomechanics and modern outlooks on its structure characteristics are described. The review provides information on theoretical developments and practical implications of the development of a new class of local hypotensive drugs that influence the trabecular meshwork tonus (Rho-kinase inhibitors).
Ophthalmology journal. 2015;8(1):69-78
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Clinical efficacy of intravitreal implant Ozurdex in combination with laser treatment in patients with retinal vein occlusions
Kulagina A.V., Badazhkov E.G., Gusarevich O.G.
Abstract
A clinical efficacy analysis of combined post-thrombotic retinopathy treatment using dexamethason intravitreal implant “Ozurdex” and retinal photocoagulation is presented. The medication promotes macular edema resorption and allows increasing visual acuity for a long period of time. Photocoagulation prevents complications, promotes edema and hemorrhage resorption. Visual acuity dynamics may be influenced by such factors as disease duration, lesion area, occlusion localization. The use of dexamethason intravitreal implant in combination with photocoagulation gives new options in treatment of patients with retinal vein occlusions
Ophthalmology journal. 2015;8(1):79-88
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A comparative evaluation of antimicrobial eye drops cytotoxicity
Aleksandrova O.I., Okolov I.N., Takhtaev Y.V., Khorolskaya J.I., Hintuba T.S., Blinova M.I.
Abstract
In addition to the spectrum of antibacterial activity of antimicrobial medicines and their pharmacokinetic and pharmacodynamic properties, their safety is also an important issue. Currently, there is no consensus on the fluoroquinolone toxicity. The purpose of this study was to compare in vitro the overall cytotoxic effect of six antibacterial fluoroquinolone eye drops: 1. Cipromed™ (ciprofloxacin 0.3 %; Sentiss Pharma Pvt. Ltd., India); 2. Floxal™ (ofloxacin 0.3 %; Dr. Gerhard Mann, Chem.-Pharm. Fabrik GmbH, Germany); 3. Oftaquix™ (levofloxacin 0.5 %; Santen Oy, Finland); 4. Signicef® (levofloxacin 0.5 %; Sentiss Pharma Pvt. Ltd., India); 5. Vigamox® (moxifloxacin 0.5 %; Alcon Laboratories, Inc., USA); 6. Zymar® (gatifloxacin 0.3 %; Allergan Sales LLC, USA). The study showed the possibility of using cultured cells for comparative evaluation of cytotoxic effects of various ophthalmic preparations. We found that tested antimicrobial medicines may have a cytostatic effect in vitro and differ in their cytotoxic potential.
Ophthalmology journal. 2015;8(1):89-97
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Pharmacoeconomic aspects of glaucoma therapy with prostaglandin analogues in patients with signs of ocular surface disease
Rudakova A.V.
Abstract
Treatment of glaucoma is prevalent in modern healthcare. The standard of care at this time in the majority of glaucoma patients is to be treated with prostaglandin analogues. The aim of the present study was to compare the cost-effectiveness and the effect on the daily quality of life of preservative-free tafluprost to benzalkonium chloride (BAK) preserved latanoprost ophthalmic solutions which are present on the Russian market. In the patients with signs of ocular surface disease. Material and methods. The cost calculation was carried out on the basis of the weighted average retail price in Moscow from March 2015. The research was carried out over a 1 yeartime period. At the assessment, we assumed that clinical efficacy of the compared drugs did not differ; but at the same time the absence of the negative impact of treatment on patients’ quality of life (QoL), assessed by COMTol questionnaire, was observed in 30 % of patients treated with BAK-preserved latanoprost and in 52 % of patients treated with preservative-free tafluprost. Results and discussion. The costs of glaucoma treatment with preservative-free tafluprost and with branded BAK-preserved latanoprost are now comparable. The cost per 1 patient without the negative impact of treatment on patients’ QoL for tafluprost (Taflotan®) was 42.6 % lower than that for branded latanoprost (Xalatan®), 72.7 % higher than that for the generic latanoprost Glaumax®, and 24.3 % higher than that for the generic latanoprost Latanomol™. The analysis of the results’ sensitivity to changes in the cost of drugs in real limits demonstrated their high reliability. When taking a decision on the reimbursement for prostaglandin analogues, one should be aware that generic latanoprost ophthalmic solutions may differ significantly from the branded drug both in physical and chemical properties as well as in clinical efficacy and safety. Conclusion. Preservative-free tafluprost and branded BAK-preserved latanoprost are characterized by comparable clinical efficacy whereas preservative-free tafluprost has better tolerability. At a comparable cost of treatment, preservative-free tafluprost has a higher cost-effectiveness. This allows recommending its inclusion in regional and federal programs for the treatment of glaucoma in patients with ocular surface disease signs.
Ophthalmology journal. 2015;8(1):99-103
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