Retinal detachment with macular involvement: in the struggle for maximal visual acuity. Part 1
- Authors: Fayzrakhmanov R.R.1, Klev V.S.1, Shishkin M.M.1, Pavlovskiy O.A.1, Sekhina O.L.1, Vaganova E.E.1
-
Affiliations:
- Pirogov National Medical and Surgical Center
- Issue: Vol 18, No 1 (2025)
- Pages: 95-104
- Section: Reviews
- Submitted: 26.07.2023
- Accepted: 14.09.2024
- Published: 04.04.2025
- URL: https://journals.eco-vector.com/ov/article/view/567763
- DOI: https://doi.org/10.17816/OV567763
- ID: 567763
Cite item
Abstract
The problem of improving visual acuity and functional outcomes in the treatment of macula-off rhegmatogenous retinal detachment remains relevant today. There is still no unified classification of this disease, which complicates the analysis and comparability of data from scientific studies. The first part of the review presents various classification options for macula-off rhegmatogenous retinal detachment, based on optical coherence tomography data of the macula. It provides data from experimental studies in this area, examines perioperative factors affecting the maximum final visual acuity, and analyzes the impact of the timing of surgical treatment of rhegmatogenous retinal detachment involving the macular area on the final maximal corrected visual acuity. Macula-off retinal detachment requires immediate surgical intervention due to better functional outcomes when the duration of macular detachment does not exceed 7 days. Despite achieving anatomical success after surgery for retinal detachment, in cases of pronounced microstructural morphological changes in the macular area, the final visual acuity may remain unsatisfactory. When predicting final visual acuity, a comprehensive assessment of the morpho-functional state of the macular retina is important.
Full Text

About the authors
Rinat R. Fayzrakhmanov
Pirogov National Medical and Surgical Center
Email: rinatft@gmail.com
ORCID iD: 0000-0002-4341-3572
SPIN-code: 1620-0083
MD, Dr. Sci. (Medicine)
Russian Federation, 70 Nizhnyaya Pervomayskaya st., Moscow, 105203Valeriya S. Klev
Pirogov National Medical and Surgical Center
Author for correspondence.
Email: klevvs@yandex.ru
ORCID iD: 0000-0001-6428-4733
MD
Russian Federation, 70 Nizhnyaya Pervomayskaya st., Moscow, 105203Mikhail M. Shishkin
Pirogov National Medical and Surgical Center
Email: michail.shishkin@yahoo.com
ORCID iD: 0000-0002-5917-6153
MD, Dr. Sci. (Medicine), Professor
Russian Federation, 70 Nizhnyaya Pervomayskaya st., Moscow, 105203Oleg A. Pavlovskiy
Pirogov National Medical and Surgical Center
Email: olegpavlovskiy@yandex.ru
ORCID iD: 0000-0003-3470-6282
SPIN-code: 6781-1504
MD, Cand. Sci. (Medicine)
Russian Federation, 70 Nizhnyaya Pervomayskaya st., Moscow, 105203Olga L. Sekhina
Pirogov National Medical and Surgical Center
Email: sekhina.ol@mail.ru
ORCID iD: 0000-0002-1499-1787
SPIN-code: 1618-3996
MD
Russian Federation, 70 Nizhnyaya Pervomayskaya st., Moscow, 105203Elena E. Vaganova
Pirogov National Medical and Surgical Center
Email: vaganova.e.e@gmail.com
ORCID iD: 0000-0003-2234-0914
SPIN-code: 5881-8822
MD
Russian Federation, 70 Nizhnyaya Pervomayskaya st., Moscow, 105203References
- Li JQ, Welchowski T, Schmid M, et al. Incidence of rhegmatogenous retinal detachment in Europe — a systematic review and meta-analysis. Ophthalmologica. 2019;242(2):81–86. doi: 10.1159/000499489
- Park DH, Choi KS, Sun HJ, Lee SJ. Factors associated with visual outcome after macula-off rhegmatogenous retinal detachment surgery. Retina. 2018;38(1):137–147. doi: 10.1097/iae.0000000000001512
- Borowicz D, Nowomiejska K, Nowakowska D, et al. Functional and morphological results of treatment of macula-on and macula-off rhegmatogenous retinal detachment with pars plana vitrectomy and sulfur hexafluoride gas tamponade. BMC Ophthalmol. 2019;19(1):118. doi: 10.1186/s12886-019-1120-3
- Ilyukhin ОЕ, Frolov МА, Ignatenko КV. Functional results of surgical treatment of retinal detachment. RUDN Journal of Medicine. 2020;24(2):156–162. doi: 10.22363/2313-0245-2020-24-2-156-162
- Lee CS, Shaver K, Yun SH, et al. Comparison of the visual outcome between macula-on and macula-off rhegmatogenous retinal detachment based on the duration of macular detachment. BMJ Open Ophthalmol. 2021;6(1):e000615. doi: 10.1136/bmjophth-2020-000615
- Klaas JE, Siedlecki J, Steel DH, et al. How should we report the foveal status in eyes with “macula-off” retinal detachment? Eye (Lond). 2023;37(2):228–234. doi: 10.1038/s41433-022-02074-7
- Boden KT, Januschowski K, Szurman P, et al. New optical coherence tomography grading system for macula-off rhegmatogenous retinal detachment: how off is off? BMJ Open Ophthalmol. 2021;6(1):e000419. doi: 10.1136/bmjophth-2019-000419
- Klaas JE, Rechl P, Feucht N, et al. Functional recovery after macula involving retinal detachment and its correlation with preoperative biomarkers in optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2021;259(9):2521–2531. doi: 10.1007/s00417-021-05113-3
- Ng H, Vermeer KA, van Meurs JC, La Heij EC. Visual acuity inadequately reflects vision-related quality of life in patients after macula-off retinal detachment surgery. Invest Ophthalmol Vis Sci. 2020;61(10):34. doi: 10.1167/iovs.61.10.34
- Abouzeid H, Wolfensberger TJ. Macular recovery after retinal detachment. Acta Ophthalmol Scand. 2006;84(5):597–605. doi: 10.1111/j.1600-0420.2006.00676.x
- van Bussel EM, van der Valk R, Bijlsma WR, La Heij EC. Impact of duration of macula-off retinal detachment on visual outcome: a systematic review and meta-analysis of literature. Retina. 2014;34(10):1917–1925. doi: 10.1097/iae.0000000000000296
- Hirata N, Iwase T, Kobayashi M, et al. Correlation between preoperative factors and final visual acuity after successful rhegmatogenous retinal reattachment. Sci Rep. 2019;9(1):3217. doi: 10.1038/s41598-019-39839-2
- Greven MA, Leng T, Silva RA, et al. Reductions in final visual acuity occur even within the first 3 days after a macula-off retinal detachment. Br J Ophthalmol. 2019;103(10):1503–1506. doi: 10.1136/bjophthalmol-2018-313191
- Hassan TS, Sarrafizadeh R, Ruby AJ, et al. The effect of duration of macular detachment on results after the scleral buckle repair of primary, macula-off retinal detachments. Ophthalmology. 2002;109(1):146–152. doi: 10.1016/s0161-6420(01)00886-7
- Karacorlu M, Sayman Muslubas I, Hocaoglu M, et al. Correlation between morphological changes and functional outcomes of recent-onset macula-off rhegmatogenous retinal detachment: prognostic factors in rhegmatogenous retinal detachment. Int Ophthalmol. 2018;38(3):1275–1283. doi: 10.1007/s10792-017-0591-6
- Khanzada MA, Wahab S, Hargun LD. Impact of duration of macula off rhegmatogenous retinal detachment on visual outcome. Pak J Med Sci. 2014;30(3):525–529. doi: 10.12669/pjms.303.4744
- Hagimura N, Suto K, Iida T, Kishi S. Optical coherence tomography of the neurosensory retina in rhegmatogenous retinal detachment. Am J Ophthalmol. 2000;129(2):186–190. doi: 10.1016/s0002-9394(99)00314-1
- Kobayashi M, Iwase T, Yamamoto K, et al. Perioperative factors that are significantly correlated with final visual acuity in eyes after successful rhegmatogenous retinal detachment surgery. PLoS ONE. 2017;12(9):e0184783. doi: 10.1371/journal.pone.0184783
- Wolfensberger TJ, Gonvers M. Optical coherence tomography in the evaluation of incomplete visual acuity recovery after maculaoff retinal detachments. Graefes Arch Clin Exp Ophthalmol. 2002;240(2):85–89. doi: 10.1007/s00417-001-0410-6
- Reese AB. Defective central vision following successful operations for detachment of the Retina. Am J Ophthalmol. 1937;20(6): 591–598.
- Bonnet M, Bievelez B, Noel A, et al. Fluorescein angiography after retinal detachment microsurgery. Graefes Arch Clin Exp Ophthalmol. 1983;221(1):35–40. doi: 10.1007/bf02171729
- Charteris DG, Sethi CS, Lewis GP, et al. Proliferative vitreoretinopathy-developments in adjunctive treatment and retinal pathology. Eye (Lond). 2002;16(4):369–374. doi: 10.1038/sj.eye.6700194
- Put MA, Croonen D, Nolte IM, et al. Postoperative recovery of visual function after macula-off rhegmatogenous retinal detachment. PLoS One. 2014;9(6):e99787. doi: 10.1371/journal.pone.0099787
- Konstantinidis L, Stappler T, Potic J, et al. Characteristics of patients with complete visual acuity recovery after vitrectomy for macula-off retinal detachment. Eye (Lond). 2021;35(10):2834–2839. doi: 10.1038/s41433-020-01322-y
- Yorston D, Donachie PHJ, Laidlaw DA, et al. Factors affecting visual recovery after successful repair of macula-off retinal detachments: findings from a large prospective UK cohort study. Eye (Lond). 2021;35(5):1431–1439. doi: 10.1038/s41433-020-1021-y
- Arroyo JG, Yang L, Bula D, Chen DF. Photoreceptor apoptosis in human retinal detachment. Am J Ophthalmol. 2005;139(4):605–610. doi: 10.1016/j.ajo.2004.11.046
- Cook B, Lewis GP, Fisher SK, Adler R. Apoptotic photoreceptor degeneration in experimental retinal detachment. Invest Ophthalmol Vis Sci. 1995;36(6):990–996.
- Linberg KA, Sakai T, Lewis GP, Fisher SK. Experimental retinal detachment in the cone-dominant ground squirrel retina: morphology and basic immunocytochemistry. Vis Neurosci. 2002;19(5):603–619. doi: 10.1017/s095252380219506x
- Lewis GP, Charteris DG, Sethi CS, et al. The ability of rapid retinal reattachment to stop or reverse the cellular and molecular events initiated by detachment. Invest Ophthalmol Vis Sci. 2002;43(7): 2412–2420.
- Ross WH, Kozy DW. Visual recovery in macula-off rhegmatogenous retinal detachments. Ophthalmology. 1998;105(11):2149–2153.
- Bayborodov YaV, Dzhusoev TM. Forecasting functional outcomes of the retina detachment surgical treatment. Oftalmokhirurgiya i Terapiya. 2002;2(2):50–53. (In Russ.) EDN: HVEMNR
- Osmanov RE. Up-to-date methods of rhegmatogenous retinal detachment surgical treatment. Vestnik Tambovskogo Gosudarstvennogo Universiteta. 2015;20(3):658–661. (In Russ.) EDN: TTHYCN
- Neroev VV, Grinchenko MI, Zueva MV, et al. Multifocal electroretinography in regmatogenic retinal detachment in the myopic eye. Russian Annals of Ophthalmology. 2009;125(1):21–27. EDN: KCKATN
- Evseev IS. Evaluation of functional results of surgical treatment of rhegmatogenous retinal detachments with a different term occurrence. Bulletin of Medical Internet Conferences. 2012;2(2):114. EDN: OQJDOX
- Avanesova TA, Kozhukhov AA, Zhavoronkov SA, et al. Reasons for the decrease in visual acuity in patients after surgery for rhegmatogenous retinal detachment, according to optical coherence tomography. Bulletin of the Russian State Medical University. 2015;(1):70–75. EDN: ULXXST
- Elghawy O, Duong R, Nigussie A, et al. Effect of surgical timing in 23-g pars plana vitrectomy for primary repair of macula-off rhegmatogenous retinal detachment, a retrospective study. BMC Ophthalmol. 2022;22(1):136. doi: 10.1186/s12886-022-02364-4
- Burton TC. Recovery of visual acuity after retinal detachment involving the macula. Trans Am Ophthalmol Soc. 1982;80:475–497.
- Frings A, Markau N, Katz T, et al. Visual recovery after retinal detachment with macula-off: is surgery within the first 72 h better than after? Br J Ophthalmol. 2016;100(11):1466–1469. doi: 10.1136/bjophthalmol-2015-308153
- Williamson TH, Shunmugam M, Rodrigues I, et al. Characteristics of rhegmatogenous retinal detachment and their relationship to visual outcome. Eye (Lond). 2013;27(9):1063–1069. doi: 10.1038/eye.2013.136
- Sukhanova AV, Fayzrakhmanov RR, Pavlovsky OA, et al. Dynamics of sensitivity parameters of the central retinal zone after vitrectomy for rhegmatogenous retinal detachment using silicone oil tamponade. Saratov Journal of Medical Scientific Research. 2021;17(2):383–388. EDN: IDVQYS
Supplementary files
