Pathogenetic Aspects of Intraventricular Hemorrhages in Extremely Premature Infants
- Authors: Saryeva O.P.1, Protsenko E.V.1
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Affiliations:
- Ivanovo Scientific-Research Institute named after V. N. Gorodkov
- Issue: Vol 31, No 3 (2023)
- Pages: 481-488
- Section: Reviews
- URL: https://journals.eco-vector.com/pavlovj/article/view/119975
- DOI: https://doi.org/10.17816/PAVLOVJ119975
- ID: 119975
Cite item
Abstract
INTRODUCTION: Intraventricular hemorrhage (IVH) is one of the most common types of the brain damage in newborns with extremely low and very low body mass. The main source of IVH in the extremely premature infants is the germinal matrix. This is a subependymal structure of the brain consisting of poorly differentiated, randomly arranged cells, well vascularized with vessels with a poor connective-tissue support. The germinal matrix a key supplier of neurons and glial cells of the brain is unique among the brain regions for its specific rate of angiogenesis and selective vulnerability to hemorrhages during its development. Etiology and pathogenesis of IVH in premature infants are highly multifactorial and have not been fully studied. In this review, the data on the key points of the pathogenesis of IVH in premature infants are generalized.
CONCLUSION: IVH is a potentially destructive disease, in the study of which a certain progress has been achieved in elucidating the causes and mechanisms of brain damage. In-depth understanding of the key points of the pathogenesis of intraventricular hemorrhage will permit to choose the optimal management tactics and develop new approaches to prevention and treatment of this pathology.
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About the authors
Ol'ga P. Saryeva
Ivanovo Scientific-Research Institute named after V. N. Gorodkov
Author for correspondence.
Email: saryevaolga@mail.ru
ORCID iD: 0000-0001-8255-2877
SPIN-code: 1436-3998
MD, Cand. Sci. (Med.)
Russian Federation, IvanovoElena V. Protsenko
Ivanovo Scientific-Research Institute named after V. N. Gorodkov
Email: procenko_e_v@mail.ru
ORCID iD: 0000-0003-0490-5686
SPIN-code: 1343-3881
MD, Dr. Sci. (Med.)
Russian Federation, IvanovoReferences
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