Participation of ABCA1 transporter in development of chronic obstructive pulmonary disease

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Abstract

Despite all achievements of the modern medicine, the problem of chronic obstructive pulmonary disease (COPD) does not lose its relevance. The current paradigm suggests a key role of macrophages in inflammation in COPD. Macrophages are known to be heterogeneous in their functions. This heterogeneity is determined by their immunometabolic profile and also by peculiarities of lipid homeostasis of cells.

Aim. To analyze the role of the ABCA1 transporter, a member of the ABC A subfamily, in the pathogenesis of COPD. The expression of ABCA1 in lung tissues is on the second place after the liver, which shows the important role of the carrier and of lipid homeostasis in the function of lungs. Analysis of the literature shows that participation of the transporter in inflammation consists in regulation of the content of cholesterol in the «lipid rafts» of the membranes, in phagocytosis and apoptosis.

Conclusion. Through regulation of the process of reverse transport of cholesterol in macrophages of lungs, ABCA1 can change their inflammatory response, which makes a significant contribution to the pathogenesis of COPD.

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About the authors

Stanislav N. Kotlyarov

Ryazan State Medical University

Author for correspondence.
Email: SKMR1@yandex.ru

MD, PhD, Associate Professor, Head of the Department of Nursing

Russian Federation, Ryazan

Anna A. Kotlyarova

Ryazan State Medical University

Email: kaa.rz@yandex.ru
ORCID iD: 0000-0002-0676-7558
SPIN-code: 9353-0139
ResearcherId: K-7882-2018

PhD in Biological Science, Assistant of the Department of Pharmacology with Pharmacy Course of the Faculty of Additional Professional Education

Russian Federation, Ryazan

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Supplementary files

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2. Fig. 1. АВСА1 expression in lungs [13]

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