Parameters of autonomic regulation in patients with focal frontal and temporal epilepsy

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Abstract

Aim. This study aimed to investigate the mechanisms of autonomic regulation and  autonomic support in focal frontal and temporal lobe epilepsy.

Materials and Methods. Thirty-six individuals were examined (19 men and 17 women; mean age 33.7±1.4 years) in the control group (without history of epileptic seizures) and 68  patients (32 men and 36 women, 34.1±1.5 years) with focal epilepsy (36 patients with frontal lobe epilepsy, of which 32 had temporal lobe epilepsy). Physiological parameters of heart rate  variability and of skin sympathetic evoked potentials were evaluated.

Results. Predomination of sympathetic influences in both groups of patients was found.  According to the analysis of skin sympathetic evoked potentials, a high activity of the  suprasegmental autonomic centers was determined in patients with epilepsy. Based on the results of the correlation analysis, the initial state in patients with temporal lobe epilepsy was  characterized by greater intrasystemic tension that reflects the high level of physiological  costs. The logit regression analysis model makes it possible to distribute patients with focal  epilepsy into groups with different disease courses on the basis of the parameters of the autonomic support of the activity.

Conclusion. In patients with focal epilepsy, predomination of sympathetic influences was  observed, as well as greater activity of the suprasegmental centers of the autonomic regulation. Intrasystemic ratios of autonomic regulation parameters demonstrate an increase in the intrasystemic tension and a limitation of functional reserves in patients with temporal lobe epilepsy. A complex of parameters of autonomic support allows, based on the logit regression analysis, to distribute patients into groups with different courses of focal epilepsy.

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About the authors

Julia I. Medvedeva

Ryazan State Medical University

Author for correspondence.
Email: medvedeva_julia89@mail.ru
ORCID iD: 0000-0003-2292-6990
SPIN-code: 9025-8780
ResearcherId: Н-1698-2018

PhD-Student of the Department of Neurology and Neurosurgery, Ryazan State Medical University

Russian Federation, Ryazan

Roman A. Zorin

Ryazan State Medical University

Email: info@eco-vector.com
ORCID iD: 0000-0003-4310-8786
SPIN-code: 5210-5747
ResearcherId: G-8833-2018

MD, PhD, Associate Professor of the  Department of Neurology and Neurosurgery, Ryazan State Medical University

Russian Federation, Ryazan

Vladimir A. Zhadnov

Ryazan State Medical University

Email: info@eco-vector.com
ORCID iD: 0000-0002-5973-1196
SPIN-code: 1632-5083
ResearcherId: A-7378-2017

MD, PhD, Professor of the Head of the Department of Neurology and Neurosurgery, Ryazan State Medical University

Russian Federation, Ryazan

Michael M. Lapkin

Ryazan State Medical University

Email: info@eco-vector.com
ORCID iD: 0000-0003-1826-8307
SPIN-code: 5744-5369
ResearcherId: S-2722-2016

MD, PhD, Professor, Head of the Department of Physiology with the Course of Psychophysiology, Ryazan State Medical University

Russian Federation, Ryazan

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Supplementary files

Supplementary Files
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1. Fig. 1. Relationship between parameters in patients with focal temporal epilepsy

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2. Fig. 2. Relationship between parameters in patients with focal frontal epilepsy

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Copyright (c) 2021 Medvedeva J.



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