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The study was completed according to ICH GCP criteria and included 127 patients with varicose disease admitted to Ryazan Regional Clinical Cardiological Dispensary in order to undergo surgical treatment. The patients were divided into three groups: the first (control) group included 14 healthy volunteers with no signs of varicose veins of lower extremities, the second group included 112 patients with varicose disease divided into three subgroups according to the CEAP classification clinical class of chronic venous insufficiency (CVI): 1 st - C2, 2 nd - C3-C4, 3 rd - C5-C6. All patients underwent a comprehensive analysis of functional state of endothelium (FSE) according to the level of its main metabolites: nitric oxide II (NO), endothelin 1-21, adhesion molecules sICAM- 1, sICAM-2, sICAM-3, and their topographic distribution. The level of endothelial dysfunction markers was studied in 15 patients with unilateral varicose disease in both healthy and affected extremity, which allowed for including them into the third group of patients. The results of the study suggest that the manifestation of endothelial dysfunction has the direct relationship with clinical classes of CVI. NO metabolites, endothelin 1-21, sICAM-1 had the highest sensitivity. The higher the CVI class, the higher the hypofunction of endothelium of varicose veins.

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