Vol 21, No 1 (2013)

Articles
INVESTIGATION OF INSULIN-, GLUCAGON-, SOMATOSTATIN-POSITIV CELLS LOCALIZATION IN THE LANGERHANS’ ISLENDS IN DIFFERENT PERIODS OF BIOCYCLE OF ANURA
Savelieva E.S.
Abstract
Article deals to immunohistochemistry investigation of endocrine cells (insulin, glucagon, somatostatin) localization in the amphibian Langerhans’ islends in different periods of biocycle. In the investigation were used pancreatic glands of three amphibian species (Pipa Pipa L. 1758, Rana temporaria, L. 1758, Rana ridibunda, Pallas 1771). Study showed relationship of quantity of different endocrine cells types is not equal depending on biocycle’s period.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):7-10
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MOLECULAR AND BIOLOGICAL MARKERS IN THE DIAGNOSIS AND PROGNOSIS OF THE GASTRIC MUCOSA INTESTINAL METAPLASIA
Vernygorodskyi S.V.
Abstract
The expression of molecular and biological markers in the intestinal metaplasia (IM) of the gastric mucosa on the basis of pathomorphological analysis was studied. It is shown that the follow useful prognostic and diagnostic value have been used: differentiation of intestinal transcription factor (CDX2), cytokeratin 7 (CK7), mucin (MUC 5 AC) and a marker of proliferative activity -Ki-67. The algorithm for pathomorphological diagnosis of gastric mucosa IM with using of immunohistochemical markers was suggested.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):11-17
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TOPOGRAPHIC ANATOMY OF THE VALVE OF INFERIOR VENA CAVA IN THE EARLY FETAL PERIOD OF HUMAN ONTOGENESIS
Lyaschenko D.N.
Abstract
On the material torsos of the 100 fetus 16-22 weeks of development were studied topographic anatomy valve of inferior vena cava in the early fetal period of human ontogenesis. The paper used a complex morphological studies: macroscopic-microscopic dissection, the method cuts for N.I. Pirogov, gistotopografical method. The study obtained morphometric data on the anatomy of the valve, provides a detailed quantitative analysis of it’s skeleton-, syn- and golotopia.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):18-22
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MORPHOFUNCTIONAL CHANGES OF PITUITARY-NEUROHYPOPHYSIS SYSTEM IN IMMATURE RATS WITH STREPTOZOTOCIN DIABETES MELLITUS
Zhurakivska O.Y.
Abstract
The research is devoted to the study of morphofunctional organization of the pituitary-neurohypophysis system of diabetes type 1. It was found that on the 14 th day after the streptozotocin diabetes simulation in 1-month old animals with hyperglycemia the increasing of functional activity of neurosecretory cells of supraoptic nuclei and increasing of bulk density in their neurosecretory granules are observed. Because of such conditions in the nervous lobe of neurohypophysis increase of bulk density of neurosecretory granules by the diffusing and the residual types are observed. On the 42 th day of the experiment constant high hyperglycemia leads to the stage of depletion of neurosecretory cells of supraoptic and paraventricular nuclei and development of dystrophic-destructive changes in them. In the neurohypophysis the reducing of bulk density of young and mature neurosecretory granules is observed. In the pituicytes of type-2 a large number of different sizes and shapes of lipid drops are observed.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):23-29
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EFFECTS OF IONIZING RADIATION ON THE ENERGY EXCHANGE IN DIFFERENT CEREBRAL CORTEX
Ilicheva V.N., Ushakov B.N.
Abstract
The comparative characteristic changes gistoenzimological profile in phylogenetically different areas of the cerebral cortex of rats after a single exposure at a dose of 0.5 Gy and 1.0 Gy. The dependence of the nature of the changes in the activity of enzymes of energy metabolism of the phylogenetic age of the crust.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):30-36
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BIOCHEMICAL MARKERS OF UNDIFFERENTIATED DYSPLASIA OF CONNECTIVE TISSUE IN PATIENTS WITH IDIOPATHIC MITRAL VALVE PROLAPSE
Osipenko I.P.
Abstract
The complex clinical and instrumental examination of 120 patients with idiopathic mitral valve prolapse was conducted. The group of comparison consisted of 30 patients with undifferentiated connective tissue dysplasia without mitral valve prolapse. There were analysed changes in the levels of magnesium, adrenal cortex hormones (aldosteron, cortisol), amino acid composition in blood serum, identified patterns between these changes and clinical displays, degree of mitral valve prolapse, the frequency of detection the heavy arrhythmias, and selected groups of risk among patients.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):37-43
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OXIDIZING UPDATING OF PROTEINS AND CHANGE OF ACTIVITY CATHEPSIN L RATS SPLEEN IN THE CONDITIONS OF MODELING DEFICIENCY OF NITRIC OXIDE SYNTHESIS
Abalenihina J.V., Fomina M.A., Isakov S.A.
Abstract
Influence inhibitor synthesis NO-synthase on activity cathepsin L and oxidising updating of proteins in a spleen of rats is studied. It is established that in the conditions deficiency of nitrogen oxide synthesis the quantity aldehyde-dinitrofenilgidrazons of neutral and basic character decreases, the quantity keton-dinitrofenilgidrazons neutral character with one-stage increase in activity cathepsin L thus increases.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):44-48
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FUNCTIONAL STATE OF ENDOTHELIUM IN DIFFERENT CLASSES OF CHRONIC VENOUS INSUFFICIENCY
Kachinskiy A.E., Nikiforova L.V.
Abstract
The study was completed according to ICH GCP criteria and included 127 patients with varicose disease admitted to Ryazan Regional Clinical Cardiological Dispensary in order to undergo surgical treatment. The patients were divided into three groups: the first (control) group included 14 healthy volunteers with no signs of varicose veins of lower extremities, the second group included 112 patients with varicose disease divided into three subgroups according to the CEAP classification clinical class of chronic venous insufficiency (CVI): 1 st - C2, 2 nd - C3-C4, 3 rd - C5-C6. All patients underwent a comprehensive analysis of functional state of endothelium (FSE) according to the level of its main metabolites: nitric oxide II (NO), endothelin 1-21, adhesion molecules sICAM- 1, sICAM-2, sICAM-3, and their topographic distribution. The level of endothelial dysfunction markers was studied in 15 patients with unilateral varicose disease in both healthy and affected extremity, which allowed for including them into the third group of patients. The results of the study suggest that the manifestation of endothelial dysfunction has the direct relationship with clinical classes of CVI. NO metabolites, endothelin 1-21, sICAM-1 had the highest sensitivity. The higher the CVI class, the higher the hypofunction of endothelium of varicose veins.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):49-55
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L-NORVALIN AND ISCHEMICAL PRECONDITIONING ACTION MECHANISMS ANALYSIS AT LIVER ISCHEMIA/REPERFUSION
Pokrovsky M.V., Lopatin D.V., Alehin S.A., Kolmykov D.I., Ivanova L.V., Lucenko V.D., Speransky S.L., Suhoterin I.V.
Abstract
In this article ischemical preconditioning and L-norvalin efficacy and mechanisms of action pharmacological analysis at liver experimental ischemia/reperfusion were made. During investigation ischemical preconditioning high effectiveness totally wasn’t blocked by glibenclamide showed. L-norvaline also showed marked hepatoprotective effect abolished by glibenclamide just partly.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):56-59
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THE INFLUENCE OF EXPERIMENTAL SUBACUTE HYPOBARIC HYPOXIA ON P-GLYCOPROTEIN FUNCTIONAL ACTIVITY
Yakusheva E.N., Chernykh I.V.
Abstract
In a study on rabbits the effect of the experimental subacute hypobaric hypoxic hypoxia on the functional activity of ATP-dependent protein transporter P-glycoprotein (Pgp) was studied. Pgp activity was assessed by pharmacokinetic of it’s marker substrate fexofenadine. It was found that 4-hour hypoxic action leads to Pgp induction.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):60-64
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INFLUENCE OF AMELANCHIER MEDIC POLYSACCHARIDE ON RESISTANCE OF BLOOD CELLS MEMBRANE
Laksaeva E.A., Sichev I.A.
Abstract
When adding to the blood a healthy donor water soluble polysaccharide complex of Amelanchier Medic fruit increases thermal, osmotic and peroxide resistance of erythrocyte membranes protecting cells from destruction caused by the action of experimental unfavorable factors
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):65-68
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ORGANIZATION OF MULTILEVEL SYSTEM TO THE CARDIAC PATIENTS IN PENZA REGION
Chizhova O.V., Sopina N.V., Konovalov O.E.
Abstract
The work presents the results of the analysis of multilevel system of medical care to cardiac patients in Penza region. It is shown that the introduction stage care system which helps patients with diseases of the circulatory system brings positive results, positive affects to demographic processes in the region.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):69-72
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STANDARDIZATION AS A BASE FOR MEDICAL CARE IMPROVEMENT IN THE RYAZAN REGION
Manukhina E.V., Artemyeva G.B.
Abstract
The goal of the research paper is to estimate the influence of the promoted medical standards on the process of medical aid rendering in hospitals. It’s indicated that medical care standards enable to plan the resources and medical care capacity more effectively within the bounds of the compulsory medical insurance territorial program. Medical standards promotion leads to methods improvement of medical aid quality management. Resource provisioning of standards increases realizing pharmacotherapy effectiveness and furthers medical personnel motivation to improve a medical care quality and reach results. Moreover, medical aid standards promotion is directed to patients and doctors’ rights protection in the solutions of conflict situations.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):73-77
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THE CONDITION OF CHILDREN AND TEENAGERS NUTRITION ORGANIZATION IN RYAZAN REGION: REGIONAL EXPERIENCE AND PROSPECTS
Grevtsova E.A., Safonkin S.V.
Abstract
The problems of organization improvement of hight-quality and safe nutrition of pupils are solved through a long-term focused programme “Ryazan region Education Development in 20102014”. In 2011 84, 3% of Ryazan region pupils got hot meals. There are different canteens in 96, 7% of institutions. In 2011 the region was a participant of experimental project on organization improvement of pupiles’ nutrition. The project covers 21 Ryazan schools (14735 pupiles) and Municipial institution “Baby food”. Health protection and education authorities work very hard on health food promotion.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):78-82
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MEDICAL AND SOCIAL CHARACTERISTICS OF PENSIONERS LIVING AT HOME AND IN THE BOARDING HOUSE
Shigabutdinov A.F.
Abstract
The article presents a comparative medico-social characteristics of pensioners living at home and in the boarding house. The analysis of age structure, education level, place of work and specialty until retirement, the presence of contacts with occupational hazards was carried out. We studied the living conditions, financial status, the presence of disability, the reasons for staying at a boarding house, an assessment of relations with relatives.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):83-87
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EXPERIENCE OF VALSARTAN USE IN GENERAL PRACTICE FOR THE TREATMENT OF COGNITIVE IMPAIRMENT IN PATIENT WITH ARTERIAL HYPERTENSION AND PAROXYSMAL ATRIAL FIBRILLATION
Krukov N.N., Portnova E.V.
Abstract
The case of successful influence optimum antihypertensive therapy on cognitive impairment is presented at the patient of 60 years with an arterial hypertension and paroxysmal atrial fibrillation.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):88-93
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MEDICAL DEMOGRAPHICAL CHARACTERISTICS OF THE CHILDREN INJURED IN THE ROAD TRAFFIC ACCIDENTS IN VORONEZH REGION
Dedov A.A., Tsomaya V.V., Ilyshina L.N.
Abstract
The yearly analysis of the main components of the structure and causes of the road traffic traumatism of the children of the preschool age and the primary school age is represented in this article. The article contains the enumeration of the age rates and frequency of traumas at road traffic accidents, conclusions and practical guidelines of the specialization of the noted facts.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):94-100
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FREE RADICAL STATUS OF IRIDOCILIARY COMPLEX AND EYE AQUEOUS HUMOR IN EXPERIMENTAL CATARACT WITHOUT TREATMENT AND ON THE BACKGROUND OF IONOL SOLUTION LOCAL THERAPY
Kolesnikov A.V.
Abstract
In experimental cataract, free radical status of iridociliary complex and of aqueous humor has been studied along with the effect of local application of the direct ionol antioxidant. Experimental cataract was induced by introduction of diquat-dibromide into the vitreous body. The development of cataract was accompanied by POL activation and sharp depression of antioxidant protection with spontaneous normalization of all biochemical indices by the 14-th experimental day. POL activation in the aqueous humor was observed over the whole experimental period, but antioxidant enzymes were not revealed with the techniques applied. Local application of ionol resulted in POL slowing-down in the aqueous humor, which indicates pathogenic tendency of its action in cataract.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):101-108
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RHINOSEPTOPLASTY PERFORMED FOR POSTTRAUMATIC COMBINED NOSE DEFORMITY IN THE FORM OF RHINOSCOLIOSIS, LORDOSIS AND KIFOSIS
Medvedev V.A.
Abstract
The article deals with the technologies of rhinoplasty applaid in the case of the combined nose deformity in the form of rhinoscoliosis with rhinolordosis and kifosis. The distinguishing features of rhinoplasty performed for the nose deformity in the form of rhinoscoliosis with rhinolordosis and kifosis are those that the removal of nasal hump is performed with help of a special directing instrument used for the endonasal removal of hump. The instrument for mobilization of nasal bones us also used. It help to mobilize, narrow and give middle position to the nasal back. The cartilage implant felling the fall of the nasal back is fixed in the place of its fall. The technologically peculiarities of performing rhinoseptoplasty described in the article let us avoid recurrent nose deformities.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):109-112
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ORTHODONTIC MALOCCLUSSION DIAGNOSING BY LATERAL HEADFILMS
Nabatchikova L.P., Horoshilkina F.Y., Chobanyan A.G.
Abstract
Results of measurement of lateral headfilms at 159 adult surveyed with I-st class occlusion and IInd and III-th class malocclussion. 6.720 changes are executed. The complex method of the analysis of lateral headfilms including offers A.Bjork, Hassund, A.M.Schwarz and own is applied.The way of an individualization of the sizes is developed at definition of 9 types: 1 - the vertical sizes of the basis of a skull; 2 - positions of forward and back points of basis of the top jaw in a horizontal direction; 3 - congenital types of a profile of the face; 4 - definitions of the basic direction of growth of obverse department of a skull; 5 - arrangements of point Articulareb a biometric articulate field; 6 - an inclination occlusion planes. It is recommended to be guided by the average us average and individualized norms of a structure of obverse department of a skull.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):114-118
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DISCLOSURE, ANALYSIS AND IDENTIFICATION OF ECDYSTEROIDS IN MYOSOTON AQUATICUM AND CUCUBALUS JAPONICUS
Darmogray S.V., Fursa N.S., Erofeeva N.S.
Abstract
By means of TLS of Myosoton aquaticum (L.) Moench. and Cucubalus japonicus L. herb ethanolic extracts a diverse assortment of ecdysteroids was revealed and their dominant components were identified with ecdysterones and polypodin B by the comparison with certainly known standards and HPLC-MS.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):119-128
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PHARMACOTHERAPY OF PULMONARY HYPERTENSION DURING PREGNANCY AND POSTPARTUM PERIOD
Ushkalova E.A., Runihina N.K., Novikova I.M.
Abstract
Pregnancy in women with pulmonary hypertension is associated with a high risk of poor outcomes and high maternal mortality rates, therefore contraindicated in this category of patients. Yet the world has accumulated some experience of pregnancy in women with pulmonary hypertension, who refused abortion, or in whom the disease was diagnosed in later stages of gestation. In this paper results of randomized and observational studies of the main and supportive pharmacotherapy in pulmonary hypertension are given, characteristics of modern drugs for the treatment of pulmonary hypertension and data on their safety during pregnancy are recommended, as well as expert opinion on drug therapy in pregnant women with pulmonary hypertension.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):129-136
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NOSOCOMIAL INFECTIONS AMONG MEDICAL PROFESSIONALS OF THERAPEAUTIC-AND-PROPHYLACTIC ORGANIZATIONS
Danilova E.S.
Abstract
Presents a review of the national and foreign data of the literature devoted to questions of studying of a role of the biological factor in formation of occupational and occupationally related morbidity among medical professionals of therapeutic-and-prophylactic organizations. Statistical data of a nosocomial infection of the medical personnel is analysed, conclusions are drawn on leading risk factors and the cores preventive measures.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):137-144
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MEDICO-SOCIAL PROBLEMS OF INCIDENCE OF INFECTIONS SEXUALLY TRANSMITTED IN MODERN CONDITIONS (THE LITERATURE REVIEW)
Zhiltsova E.E., Volkova S.B.
Abstract
Infections sexually transmitted and their complications lead to considerable social and economic expenses entering into ten the most frequent reasons of the request for medical care and making the essential item of expenditure both national budgets of health care and family expenses. Social expenses also include the conflicts between sexual partners and violence in their family.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):145-150
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DILATED CARDIOMYOPATHY: A MODERN VIEW OF DISEASE
Zotova L.A.
Abstract
Dilated cardiomyopathy - the primary lesion of the myocardium due to various reasons, characterized by a pronounced expansion of the heart chambers and decreased systolic and diastolic functions. Among the etiological causes in the first place should include a genetic predisposition. Diagnosis of the disease involves the identification of specific changes in echocardiography and the exclusion of other causes of heart failure. Therapy is symptomatic. Questions such as prediction of disease, improved survival, pathogenetic therapy, still await solution.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):151-157
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ARSENAL OF MODERN MEDICAL LINERS USED IN DENTISTRY (REVIEW OF LITERATURE DATA)
Chen W., Elouazzani M., Kazanceva G.P.
Abstract
The article is devoted to the review of the modern literary data regarding prevalence of caries of teeth according to WHO, arsenal of medical liners used for treatment of deep caries of teeth. Influence of different groups of medical liners to reparative function of pulp of tooth is noticed in the article.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):158-162
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Chlen-korrespondentu RAMN, professoru L.V. Kakturskomu - 70 let
- -.
Abstract
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):163-165
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K SVEDENIYu AVTOROV
- -.
Abstract
I.P. Pavlov Russian Medical Biological Herald. 2013;21(1):167-170
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