MORPHOFUNCTIONAL CHARACTERISTICS TESTES WISTAR RATS EXPOSED TO LPS IN GIPERANDROGENEMII

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We investigated the morphological changes of the testes of Wistar rats with acute gram-negative ENDOTOXICOSIS against giperandrogenemii. In acute ENDOTOXICOSIS 1 st day after injection of lipopolysaccharide (LPS) showed a reduction in the level of total testosterone in serum, increase of Leydig cell nuclei and the diameters of the convoluted tubules, on the 7 th day, these figures were normalized. The introduction of LPS against giperandrogenemii recorded the most pronounced morphological changes, including significant reduction in the index of spermatogenesis, which reflects the suppression of spermatogenic function.

参考

  1. Писарев В. Б. Бактериальный эндотоксикоз: взгляд патолога. / Н.В. Богомолова, В.В. Новочадов.- Волгоград: Изд-во ВолГМУ, 2008.- 208 с.
  2. Ухов Ю. И. Морфометрические методы в оценке функционального состояния семенников / А.Ф. Астраханцев // Архив анатомии, гистологии и эмбриологии.- 1983.- Т. LXXXIV, № 3.- С.66-72.
  3. A study of the prostate, androgens and sexual activity of male rats М.Е. Hernandez et al. // Reprod Biol Endocrinol. - 2007.- Vol. 16, № 5:11.
  4. Bacterial lipopolysaccharide-induced inflammation compromises testicular function at multiple levels in vivo / M.K. O'Bryan et al. // Endocrinology.- 2000.- Vol.141, №1.- P. 238-246.
  5. Hales D.B. Role of cytokines in testicular function / T. Diemer, K.H. Hales // Endocrine.-1999. - Vol. 10, № 3.- P.201-217.
  6. Handelsman D.J. Androgen therapy in chronic renal failure / P.Y Liu. // Baillieres Clin Endocrinol Metab.- 1998.- Vol.12, № 3.- P.485-500.
  7. Katznelson L. Therapeutic role of androgens in the treatment of osteoporosis in men // Baillieres Clin Endocrinol Metab.- 1998. Vol. 12, № 3.- P. 453-470.
  8. Klein S. L. Sex hormones and immunity to infection / C.W Roberts.- Heidelberg: Springer, 2010.- 319 p.
  9. Wenk M. Male contraception: a realistic option? / E. Nieschlag // Eur J Contracept Reprod Health Care.- 2006.- Vol.11, № 2.- P. 69-80.

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版权所有 © Vasil'eva S.G., Mkhitarov V.A., Kosyreva A.M., Makarova O.V., Vassilievа S.G., Mkhitarov V.A., Kosyrevа A.M., Makarovа O.V., 2011

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