Vol 19, No 2 (2011)

Articles
CELL AND NUCLEAR SIZE IN THE REGENERATING FETAL LIVER OF RATS
El'chaninov A.V., Bol'shakova G.B., Elchaninov A.V., B Bolshakova G.
Abstract
The contribution of hypertrophy of hepatocytes in the recovery of body mass on the model of liver regeneration in the rat fetus was studied. Significant increase in the size of hepatocytes and their nuclei in the regenerating liver of fetal rats in comparison with an intact were not detected. Thus, hypertrophy of the cells virtually played no role in the regeneration of the fetal liver, which is subject to the same rules as the normal growth of the body.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):1-1
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SEMAX INFLUENCE ON RAT CARDIOMYOCITE APOPTOTIC CELL DEATH IN IRREVERSIBLE ISCHEMIA AND ISCHEMIA-REPERFUSION
Berdalin A.B., Gavrilova S.A., Golubeva A.V., Buravkov S.V., Koshelev V.B., Berdalin A.B., Gavrilova S.A., Golebeva A.V., Buravkov S.V., Koshelev V.B.
Abstract
5 groups of male rats were investigated: control group; irreversible ischemia with drug and without; the animals with reperfusion after 2.5 hours of ischemia with drug and without it. Samples for light microscopy (haematoxylin-eosin and TUNEL-analysis) of the risk area (anterior wall of left ventricle) and conditionally intact myocardium (lateral wall and interventricular septum) were taken 72 hours after intervention. Semax were injected intraperitoneally at a dose of 150 mg / kg after 15 minutes and after 2 hours 15 minutes after ligation of coronary artery. The necrosis was formed in the anterior wall area both under irreversible ischemia and ischemia-reperfusion. Substantial morphological changes also developed in areas of relatively intact myocardium. These signs are accompanied by a significant increase of apoptotic index. Semax had no effects on the morphology of myocardium, but significantly reduced apoptosis of cardiomyocytes.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):2-2
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STUDY OF EXPRESSION P16INK4A, KI-67, VEGF AND E-CADHERIN SQUAMOUS INTRAEPITHELIAL LESIONS OF CERVIX
Shamarakova M.V., Shamarakova M.V.
Abstract
The article presents the results of a study of the functional state of squamous intraepithelial lesions of the cervix, using modern molecular biology techniques, the selection of biomarkers to facilitate the diagnosis of epithelial proliferative changes, and determine the flow of precancerous cervical conditions. The study showed that lesions with structural features of CIN2 have different malignant potential and therefore the morphological criteria of a pathological process does not reflect the nature of the biological process.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):3-3
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MORPHOLOGICAL CHARACTERISTICS OF IN THE MEDIAL NUCLEI IN MAMMILLARY BODIES OF BRAIN OF MEN WITH CHRONIC ALCOHOL INTOXICATION
Pavlov A.V., Pavlov A.V.
Abstract
The article presents the morphometric analysis of the features of medial cell nuclei of the mammillary bodies of the human brain in chronic alcohol intoxication.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):4-4
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MORPHOFUNCTIONAL CHARACTERISTICS TESTES WISTAR RATS EXPOSED TO LPS IN GIPERANDROGENEMII
Vasil'eva S.G., Mkhitarov V.A., Kosyreva A.M., Makarova O.V., Vassilievа S.G., Mkhitarov V.A., Kosyrevа A.M., Makarovа O.V.
Abstract
We investigated the morphological changes of the testes of Wistar rats with acute gram-negative ENDOTOXICOSIS against giperandrogenemii. In acute ENDOTOXICOSIS 1 st day after injection of lipopolysaccharide (LPS) showed a reduction in the level of total testosterone in serum, increase of Leydig cell nuclei and the diameters of the convoluted tubules, on the 7 th day, these figures were normalized. The introduction of LPS against giperandrogenemii recorded the most pronounced morphological changes, including significant reduction in the index of spermatogenesis, which reflects the suppression of spermatogenic function.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):5-5
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IT THE COMPARATIVE DIAGNOSTICS OF H. PYLORI INFECTION BY HISTOLOGICAL AND SOME RAPID UREASE-METODS
Leont'eva N.I., Shcherbakov I.T., Gracheva N.M., Khrennikov B.N., Shcherbakova E.G., Partin O.S., Leonteva N.I., Shcherbacov I.T., Gracheva N.M., Khrennicov B.N., Shcherbacova E.G., Partin O.S.
Abstract
The histology, gistobacterioskopic and urease Express-metods (Helpil-test and Helic-test) studiend 272 biopsies of the mucous membrane of different pars of the stomach and duodenum. Have it established that the pyloric 4 helicobacter in gastrobiopsis is histological verified in 95,9 %, by the urease Helpil - test in 83,6 % and by the urease Helik-test only in 63,2%.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):6-6
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PREPARATION OF PATIENTS WITH ДИСБИОЗОМ VAGINAS TO INTRAUTERINE INTERVENTIONS
Lugovaya A.V., Lugovaya A.V.
Abstract
Last decade against a wide circulation of chronic infectious-inflammatory processes, number increases immmunodeficilis conditions, growth of number of diseases, sexually transmitted, the increasing value get associations of microorganisms and activation of is conditional-pathogenic microflora. At use of non-standard methods of diagnostics and treatment, at wrong treatment of diseases, the pathological conditions demanding their timely correction arise ignoring social and demographic factors. In our research for the purpose of preparation of patients with disbyosis vaginas to intrauterine interventions used a preparation from live apatogenitia sort bacteria "Bacillus" "Sporobakterin" possessing a wide spectrum of action who has allowed to lower several times frequency of relapses disbyosis in the postoperative period.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):7-7
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POSSIBLE WAYS OF STIMULATION OF NITRIC OXIDE PRODUCTION AS THE MAIN INDUCTOR OF ENDOTHELIAL DYSFUNCTION USING CARDIOTROPIC DRUGS IN PATIENTS WITH PERIPHERAL OCCLUSIVE ARTERIAL DISEASE
Shval'b P.G., Kalinin R.E., Pshennikov A.S., Shvalb P.G., Kalinin R.E., Pshennikov A.S.
Abstract
The open randomized trial meeting the ICH GCP criteria included 4 groups of patients with peripheral occlusive arterial disease, stage IIA-III according to the Fontaine classification in modification by Pokrovsky. The first group was given 5mg of nebivolol qd po, the second was given perindopril 5, 10 mg qd po, the third - L-arginine 500mg bid po during 30 days. Group 4 was a control group. After a 30-days period of conservative therapy we observed a 70% increase of NO level in the first group, 95% increase in the 2nd group and 539% increase in the 3rd. A reliable increase of nitric oxide metabolites correlated with improvement in clinical findings as well as functional tests. Treadmill test improved by 22%, 20%, and 32% respectively. Rheographic test improved in all study groups and its values exceeded the normal ones by 15-25% (P<0.05).
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):8-8
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THE CONDITIONS OF PERSONNEL POTENTIAL FORMING IN NIZHNIY NOVGOROD REGION
Khaletskiy I.G., Kamaev I.A., Grib M.N., Perevezentsev E.A., Khlapov A.L., Chalecki I.G., Kamaev I.A., Grib M.N., Perevezentsev E.A., Khlapov A.L.
Abstract
The methods of approaching the solution of the personnel problems in the modern conditions and the forming, keeping and developing of medical personnel quality on the base of the analysis and assessing of main trends of personnel policy and exposure of present - day problems were consided.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):9-9
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A STATISTICAL APPROACH TO HYGIENIC ASSESSMENT OF DRINKING-WATER DYNAMICS IN THE TERRITORY
Pozdnyakova M.A., Fedotova I.V., Lipshits D.A., Koroleva T.A., Pozdnyakova M.A., Fedotova I.V., A Lipschitz D., Koroleva T.A.
Abstract
Poor quality of drinking water poses a threat to public health, what determines the absolute importance of objective and complete assessment of water quality, the choice of indicators and methods of calculation based on statistical methodology. The proposed statistical approach for assessing the hygienic quality of drinking water areas in the dynamics is innovative because it allows to simulate and forecast trends in the quality of water areas, distinguished statistically significant fluctuations in health indicators.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):10-10
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THE PROBLEM OF STUDYING HEALTH HIGH SCHOOL STUDENTS
Agafonova L.V., Dvoeglazova S.V., Zaikina N.V., Semushina I.V., Agafonovа L.V., Dvoeglazova S.V., Zaikinа N.V., Semushina I.V.
Abstract
Monitoring the health of the modern student, and risk factors of the educational environment should include not only evaluation intraschool environment, but also to assess the psycho-physiological status of the student in terms of functional reserve of the organism, as well as a rapid assessment of the functional state of the heart.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):11-11
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REPRODUCTIVE HEALTH OF WOMEN LATE ФЕРТИЛЬНОГО AGE AS THE MEDIKO-SOCIAL PROBLEM
Kiselev A.M., Konovalov O.E., Kiselev A.M., Konovalov O.E.
Abstract
In article the characteristic of modern lines of gynecologic disease and reproductive health of the female population of Russia is resulted. Risk factors of reproductive losses at women late фертильного age are considered. The estimation of the developed structure of akushersko-gynecologic service in the country is given.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):12-12
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REALIZATION OF PROGRAM-TARGET APPROACH TO OPTIMIZING OB GYN AND PEDIATRIC CARE IN THE PENZA REGION
Mysyakov V.B., Mysyakov V.B.
Abstract
In article the characteristic realized since 1998 in territory of the Penza region of target programs on health protection of the female and children's population is presented. The subroutine purpose was social support of motherhood and the childhood, creation of conditions for health protection of mother and a birth of healthy children, protection of reproductive health, the prevention and decrease in parent and infantile disease and death rate, improvement of a food of mothers and children, preservation and strengthening of health of children and teenagers.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):13-13
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PREVALENCE OF COPD RISK FACTORS IN PEOPLE LIVING IN COUNTRYSIDE
Kotlyarov S.N., Kotlyarov S.N.
Abstract
Chronic Obstructive Pulmonary Disease (COPD) is a very acute medical problem. It's serious social and economical burden. Disease development is connected with ecological factors exposure. Smoking is predominant among risk factors. So we were to estimate risk factors in people of countryside. 3621 people living in countyside of Ryazan region were asked with the help of standardized GARD questionnaire. Significant prevalence of COPD risk factors had been revealed. Smoking was one of the most wide-spread, it could achieve 63,18% in males 18-39 years of age.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):14-14
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THE METHOD ELECTRONIC AUSKULTATII: USE CHILDREN FOR THE DIAGNOSTICS OF THE BRONCHIAL ASTHMA
Dmitriev A.V., Filimonova T.A., Sharovskaya G.I., Dmitriev А.V., Filimonova Т.А., Sharovskaja G.I.
Abstract
In article are presented results of the using the method electronic auscultations beside healthy and children with bronchial asthma. They Are Shown comparative features sound parameter, relationship of the standard methods of the study (the spirometry, peakfloumetry) and method electronic auscultations. Will Revealled diagnostic value given method in group детей with bronchial asthma.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):15-15
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AUTOAGGRESSIVE POTENTIAL OF PATIENTS WITH PSYCHIC PATHOLOGY COMBINED WITH ALCOHOL ADDICTION HAVING COMMITTED SOCIALLY DANGEROUS ACTS
Kiselev D.N., Kiselev D.N.
Abstract
A comparative examination was conducted of a group of patients with a psychic pathology combined with alcohol addiction who committed socially dangerous acts, and of a corresponding group of patients who did not commit such acts. Increase in the number of parasuicides, in risky behavior (with associated mutilations), in antisocial behavior (with associated precondemnations), and in frequency of intake of psychoactive substances in the first group is shown. Conclusions about a similar nature of aggression, of autoaggression and dependence of peculiarities of criminal behavior on the type of alcohol addiction are made.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):16-16
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SUICIDAL, NARCOLOGICAL AND PERSONAL-PSYCHOLOGICAL PECULIARITIES OF MEN SUFFERING FROMALCOHOL DEPENDENCE MARRIED TO WOMEN HAVING SUICIDAL ACTIVITY
Merinov A.V., Shustov D.I., Merinov A.V., Shustov D.I.
Abstract
The article studies the influence of suicidal activity of wives on suicidal, narcological indexes and experimental-psychological specifications of their husbands suffering from alcohol dependence. It has been found out that men suffering from alcohol dependence married to women having suicidal activity as distinct from men suffering from alcohol dependence married to women without suicidal activity reveal suicidal activity more frequently (phenomenon of suicidal matrimonial comorbidity). They also reveal non-suicidal behavioral patterns more frequently and prosuicidal predictors are quite common in them.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):17-17
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TREATMENT-DIAGNOSTIC TACTICS AT NON PALPABLE BREAST LESIONS
Kulikov E.P., Yukhanov S.V., Zagadaev A.P., Sashina E.L., Kulicov E.P., Juhanov S.V., Zagadaev A.P., Sashina E.L.
Abstract
In article results of inspection of 27 patients with non palpable breast leaseons are presented. To all patients the fine needle aspiration biopsy (FNAB) non palpable breast lesions under control of ultrasonic with the subsequent cytologic research was spent. Operative treatment is spent to 11 patients (41 %), in 11 cases (41 %) dynamic supervision is recommended, to 5 patients (18 %) conservative therapy is appointed. The informative material for cytologic research is received at 14 patients. Thus in 51 % of cases it was possible to get morphological verification from non palpable breast lesions.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):18-18
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RISK OF PULMONARY EMBOLISM ASSOCIATED WITH SUPERFICIAL VEIN THROMBOPHLEBITIS
Kalinin R.E., Narizhnyy M.V., Suchkov I.A., Kalinin R.E., Narizhniy M.V., Suchkov I.A.
Abstract
This article represents the evaluation of risk of pulmonary embolism associated with superficial vein thrombophlebitis based on observations in more than 500 patients.We found that acute thrombophlebitis was associated with varicose veins stage C3 to C6 of the CEAP classification in 30% cases and varicose veins with insignificant valve insufficiency verified by duplex ultrasound scan in 35% patients. During the surgical operations we found thrombosis extending to the saphenofemoral junction in 90 patients (17.8%) while in 35 patients the thrombi were found in femoral vein. Thus 24.7% of patients were at high risk of pulmonary thromboembolism.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):19-19
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THE REALIZATION OF GENERAL ADAPTATION SYNDROME IN THE SYSTEM OF HAEMOSTASIS AT THE LOCAL AND SYSTEM LEVELS BY ENDOVIDEOSCOPIC INVASIONS
Ivanov V.V., Ivanov V.V.
Abstract
In the accomplished clinical-experimental research the results of studying coagulation, countercoagulation and fibrinolitic system and functional activity of thrombocytes during endovideoscopic invasions. Here are shown differences in the system of haemocoagulation at the local and system levels, the dependence of the current changes on the stress reaction level.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):20-20
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THE ANALYSIS OF PERSONNEL SAFETY IN PHARMACY
Kuznetsov D.A., Kuznetsov D.A.
Abstract
In this article considers personnel safety, as a component of pharmaceutical economic safety. On the basis of a principle subsidiarity the concept of personnel safety and a matrix of support of personnel safety of the pharmaceutical organization is offered. With usage of the theory of fuzzy sets the system of a quantitative estimation of personnel making economic safety of the pharmaceutical organization is formulated. In operation major factors of personnel safety are studied, significances of weight coefficients are installed.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):21-21
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СHANGES OF HEMODYNAMICS IN THE PATIENTS BRONCHIAL ASTHMA
Khodyushina I.N., Uryas'ev O.M., Khodyushina I.N., Uryasyev O.M.
Abstract
Influence of reversible obstruction , that is typical for asthma, on intracardial hemdly names is not quite clear. It is known that corelatiens exist between pulmonary hemodynamics disorders and the gravity of obstructive syndrome and also the phase of inflammation. The reological changes (hyporviscidity) lead to pulmonary and cardial circulation disorders. Pulmanary hypertension taking place in astma attack increases loading of the right chambers of the heart. Hypoxemy leads to disbalance between oxygen clemand and distribution .All these factors lead to cardial respiratory insufficiency.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):22-22
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AUTOIMMUNE MECHANISMS IN THE PATHOGENESIS OF THE PRIMARY OPEN ANGLE GLAUCOMA (The literature review)
Sokolov V.A., Mkkhinini N., Levanova O.N., Sokolov V.A., Mkhinini N., Levanova O.N.
Abstract
Numerous researches testify to presence of autoimmune aggression in pathogenesis POAG. Antibodies to various fabric components of an eyeball, both in forward, and in a back piece of an eye are found out. There are qualitative changes in collagenic structure of a sclera. There are products of pathological synthesis of the collagenic fibers having diagnostic, toxic, prognostic value. Change of a spectrum of immunoglobulins, cellular structure of immunocompetent cells testify that are involved in pathogenesis POAG not only autoimmune mechanisms of an autoaggression, but also change of natural immunity, and weakening of regulating functions.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):23-23
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THE QUALITY OF LIFE OF PATIENTS WITH MENTAL DISORDERS
Filimonov A.P., Volodin B.Y., Filimonov A.P., Volodin B.Y.
Abstract
Now the conception of Quality of Life is used in medicine very often, and in psychiatry in particular. Many investigations show that the mental disorders lead to strong disturbance of different features of Quality of Life. The psychiatric symptoms, sex, self-esteem, the duration of the disease, the risk of loosing job, social stigma and social isolation have a great influence on Quality of Life of psychiatric patients. This information may be used for planning psychiatric service and also for the assessment of this service's results.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):24-24
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Zasluzhennomu deyatelyunauki RossiyskoyFederatsii, doktorumeditsinskikh nauk,professoruV.Ya Garmashu - 80 let
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Abstract
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):25-25
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PRAVILA PREDSTAVLENIYa RUKOPISEY
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Abstract
I.P. Pavlov Russian Medical Biological Herald. 2011;19(2):26-26
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