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Orientation andcomposition ofcollagen fibers withinthe scar aftermyocadial lesion in ratfetuses
- 期: 卷 17, 编号 3 (2009)
- 页面: 9-15
- 栏目: Articles
- ##submission.dateSubmitted##: 28.10.2016
- ##submission.datePublished##: 15.09.2009
- URL: https://journals.eco-vector.com/pavlovj/article/view/5247
- DOI: https://doi.org/10.17816/PAVLOVJ200939-15
- ID: 5247
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This study was undertaken to examine orientation and composition of collagen fibers within the myocardial scar after mechanical injury in 16-day-old rat fetuses and in adult male rats. Measurements were performed from 7 to 40 days after lesion. Angles of fiber bundles relative to the longitudinal axis of wound channel were measured and were analyzed with circular statistic techniques. Proportion of collagen types I and III was determined when studying sections stained with picrosirius red under polarized light. In adult myocardium fibers of collagen type I were abundant and longitudinally aligned, the lesion developed into a mature scar. Fetal scar contained thinner fibers, which did not display a homogeneous distribution. This suggests that fetal scar is immature, its mechanical strength is less and that fetal myocardium shows incomplete repair.
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