Сomparative characteristics of induced sputum cellular composition in patients with mild and moderate stable COPD, patients with chronic bronchitis and smokers

Abstract

Comparative characteristics of induced sputum cellular composition in 11mild and 12 moderate stable COPD patients, 30 patients with chronic bronchitis and 13 smokers have been studied. Patients with mild stable COPD were found to have increased absolute number of all cells, including neutrophils and macrophages in the induced sputum in comparison with patients with chronic bronchitis. The inflammatory process in the lungs increases along with airflow limitation degree

References

  1. Глобальная стратегия диагностики, лечения и профилактики хронической обструктивной болезни легких / пер. с англ. под ред. Чучалина А.Г. -М.: Атмосфера, 2007. - 96 с.
  2. Респираторная медицина. Руководство под ред. А.Г. Чучалина, том 1, стр. 597 - 651, Москва, ГЭОТАР, 2007.
  3. Airway inflammation contributes to health status in COPD: a cross-sectional study. J.B. Snoeck-Stroband et al.// Respiratory Research 2006, 7:140.
  4. Barnes P.J. / Cells and mediators of chronic obstructive pulmonary disease. Management of Chronic Obstructive Pulmonary Disease // P.J. Barnes, M.G. Cosio; под ред. N.M. Siafakas //UK.:European Respiratory Society Monograph, <http://erm.ersjournals.com/site/misc/archive.xhtml> 2006. - №38. - ps 130-158.
  5. Chronic bronchitis sub-phenotype within COPD: inflammation in sputum and biopsies /J. B. Snoeck-Stroband <http://www.ersj.org.uk/search?author1=J.+B.+Snoeck-Stroband&sortspec=date&submit=Submit> et al.// European Respiratory Journal . - 2008. - v. 31. - № 1. - ps 70-77.
  6. Chung K.F. Cytokines in chronic obstructive pulmonary disease/ K.F. Chung// European Respiratory Journal. - 2001. - №18. - ps 50-59.
  7. Eosinophils in induced sputum from asymptomatic smokers with normal lung function /R.D'Ippolito et al.// Respiratory Medicine. - 2001. - V. 95, № 12 <http://www.resmedjournal.com/issues?issue_key=S0954-6111(00)X0004-2>. - ps 69-974.
  8. International variation in the prevalence of COPD (The BOLD Study): a population-based prevalence study/ S. Buist et al. // Lancet. - 2007. - V. 370, <http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%234886%232007%23996290410%23666996%23FLA%23&_cdi=4886&_pubType=J&view=c&_auth=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=64a45b2c91f8f30ed20d9f1d8e1ab7e1>ps 741-750.
  9. MacNee W. Pathogenesis of Chronic Obstructive Pulmonary Disease / W. MacNee // The Proceedings of the American Thoracic Society. - 2005. - № 2. - ps 258-266.
  10. Sex hormones and Immunity to infection. S.Klein, C.W.Roberts. ps. 319. Springer-Verlag Berlin Hidelberg. 2010.
  11. Sputum neutrophils as a biomarker in COPD: findings from the ECLIPSE study/ Singh D. et al.// Respiratory Research. - 2010. - 11:77.
  12. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper/B.R. Celli1 et al. // European Respiratory Journal.- 2004.- № 23. - ps 932-946.
  13. Tsoumakidou <http://www.journals.elsevierhealth.com/periodicals/yrmed/article/PIIS0954611103000350/abstract>
  14. M. Induced sputum in the investigation of airway inflammation of COPD / M. Tsoumakidou <http://www.journals.elsevierhealth.com/periodicals/yrmed/article/PIIS0954611103000350/abstract>,
  15. N. Tzanakis <http://www.journals.elsevierhealth.com/periodicals/yrmed/article/PIIS0954611103000350/abstract>,
  16. N.M. Siafakas <http://www.journals.elsevierhealth.com/periodicals/yrmed/article/PIIS0954611103000350/abstract> //
  17. Respiratory medicine. - 2003. № 97 <http://www.resmedjournal.com/issues?Vol=97>, Ps 863-871.
  18. The cellular composition of induced sputum in chronic obstructive pulmonary disease / R.A. Peleman et al.// European Respiratory Journal. - 1999. - v. 13 № 4.- ps 839-843.
  19. Wouters E. F. M. Local and Systemic Inflammation in Chronic Obstructive Pulmonary Disease / Wouters E. F. M.// The Proceedings of the American Thoracic Society. - № 2. - ps 26-33. 2005.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2011 Medvedev I.D., Ishina T.I., Makarova O.V., Makhnach G.K., Nikonova E.V., Sidorova E.I., Podzolkov V.I., Medvedev I.D., Ishina T.I., Makarova O.V., Nikonova E.V., Mahnach G.K., Sidorova E.I., Podzolkov V.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Media Registry Entry of the Federal Service for Supervision of Communications, Information Technology and Mass Communications (Roskomnadzor) PI No. FS77-76803 dated September 24, 2019.



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies